Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
Sillanpää, E., Törmäkangas, T., Rantanen, T., Kaprio, J., & Sipilä, S. (2016). Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?. AGE, 38(2), Article 34. https://doi.org/10.1007/s11357-016-9898-x
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AGEDate
2016Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© American Aging Association 2016. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but
its association with age-related decline in physical functioning and the development of
disability is less clear. This study examined the associations between LTL and physical
functioning, and investigated whether LTL predicts level of physical functioning over an 11-
year follow-up.
Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study.
Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min
walking distance and level of physical activity (PA). Walking distance was measured at
baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3- and
11-year follow-ups. The baseline analysis was performed with path models, adjusted with
age and within-pair dependence of twin pairs. The longitudinal analysis was performed with
a repeated measures linear model adjusted for age and longitudinal within-pair dependence.
A non-random missing data analysis was utilized.
Results: At baseline, in all individuals LTL was associated with PA (est. 0.14 SE 0.06 p=0.011),
but not with walking distance. Over the follow-up, a borderline significant association was
observed between LTL and walking distance (est. 0.14 SE 0.07 p=0.060) and a significant
association between LTL and PA (est. 0.19 SE 0.06 p=0.001).
Conclusions: The results suggest that LTL is associated with PA and may, therefore, serve as
a biomarker predicting the development of disability. Longitudinal associations between LTL
and PA were observed only when nonrandom data missingness was taken into account in
the analysis.
...
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Springer Netherlands; American Aging AssociationISSN Search the Publication Forum
2452-0756Keywords
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