Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?
Sillanpää, E., Törmäkangas, T., Rantanen, T., Kaprio, J., & Sipilä, S. (2016). Does telomere length predict decline in physical functioning in older twin sisters during an 11-year follow-up?. AGE, 38(2), Article 34. https://doi.org/10.1007/s11357-016-9898-x
Julkaistu sarjassa
AGEPäivämäärä
2016Oppiaine
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingTekijänoikeudet
© American Aging Association 2016. This is a final draft version of an article whose final and definitive form has been published by Springer. Published in this repository with the kind permission of the publisher.
Background: Leucocyte telomere length (LTL) is known to be associated with mortality, but
its association with age-related decline in physical functioning and the development of
disability is less clear. This study examined the associations between LTL and physical
functioning, and investigated whether LTL predicts level of physical functioning over an 11-
year follow-up.
Methods: Older mono- (MZ) and dizygotic (DZ) twin sisters (n=386) participated in the study.
Relative LTL was measured by qPCR at baseline. Physical functioning was measured by 6-min
walking distance and level of physical activity (PA). Walking distance was measured at
baseline and at 3-year follow-up. PA was assessed by questionnaire at baseline and at 3- and
11-year follow-ups. The baseline analysis was performed with path models, adjusted with
age and within-pair dependence of twin pairs. The longitudinal analysis was performed with
a repeated measures linear model adjusted for age and longitudinal within-pair dependence.
A non-random missing data analysis was utilized.
Results: At baseline, in all individuals LTL was associated with PA (est. 0.14 SE 0.06 p=0.011),
but not with walking distance. Over the follow-up, a borderline significant association was
observed between LTL and walking distance (est. 0.14 SE 0.07 p=0.060) and a significant
association between LTL and PA (est. 0.19 SE 0.06 p=0.001).
Conclusions: The results suggest that LTL is associated with PA and may, therefore, serve as
a biomarker predicting the development of disability. Longitudinal associations between LTL
and PA were observed only when nonrandom data missingness was taken into account in
the analysis.
...
Julkaisija
Springer Netherlands; American Aging AssociationISSN Hae Julkaisufoorumista
2452-0756Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/25594130
Metadata
Näytä kaikki kuvailutiedotKokoelmat
- Liikuntatieteiden tiedekunta [3139]
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Effectiveness of a workplace physical exercise intervention on the functioning, work ability, and subjective well-being of office workers : a cluster randomised controlled cross-over trial with a one-year follow-up
Sjögren, Tuulikki (University of Jyväskylä, 2006)The main aim of this study was to investigate the feasibility and the effects of workplace physical exercise intervention on physical and psychosocial functioning, work ability, and general subjective well-being. Dose of ... -
Online acceptance and commitment therapy (iACT) for adults with persistent physical symptoms : 3-month follow-up study of a randomized controlled trial
Lappalainen, Päivi; Keinonen, Katariina; Lappalainen, Raimo; Selinheimo, Sanna; Vuokko, Aki; Sainio, Markku; Liesto, Sanna; Tolvanen, Asko; Paunio, Tiina (Elsevier, 2024)Objective Persistent physical symptoms (PPS) represent a major health problem affecting daily functioning. This RCT aimed to examine whether a guided Internet-based treatment based on acceptance and commitment therapy ... -
Multidimensional physical activity profiles and changes in physical function and self-reported walking ability among community-dwelling older adults : a 4-year follow-up
Palmberg, Lotta; Karavirta, Laura; Löppönen, Antti; Hyvärinen, Matti; Rantanen, Taina; Rantalainen, Timo (Oxford University Press (OUP), 2023)Purpose Physical activity (PA) is multidimensional but often assessed using single metrics. We studied how data-driven PA profiles predict changes in physical functioning and self-reported walking ability over time among ... -
Physical function and lean body mass as predictors of bone loss after hip fracture : a prospective follow-up study
Suominen, Tuuli H.; Edgren, Johanna; Salpakoski, Anu; Kallinen, Mauri; Cervinka, Tomas; Rantalainen, Timo; Törmäkangas, Timo; Heinonen, Ari; Sipilä, Sarianna (BioMed Central, 2020)Background Predictors of bone deterioration after hip fracture have not been well characterized. The aim of this study was to examine the associations of physical function and lean body mass (LBM) with loss of bone density ... -
The Association Between Epigenetic Clocks and Physical Functioning in Older Women : A 3-Year Follow-up
Föhr, Tiina; Törmäkangas, Timo; Lankila, Hannamari; Viljanen, Anne; Rantanen, Taina; Ollikainen, Miina; Kaprio, Jaakko; Sillanpää, Elina (Oxford University Press, 2022)Background Epigenetic clocks are composite markers developed to predict chronological age or mortality risk from DNA methylation (DNAm) data. The present study investigated the associations between four epigenetic clocks ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.