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dc.contributor.authorKesäniemi, Jenni
dc.contributor.authorJernfors, Toni
dc.contributor.authorLavrinienko, Anton
dc.contributor.authorKivisaari, Kati
dc.contributor.authorKiljunen, Mikko
dc.contributor.authorMappes, Tapio
dc.contributor.authorWatts, Phillip C.
dc.date.accessioned2019-09-17T07:19:29Z
dc.date.available2019-09-17T07:19:29Z
dc.date.issued2019
dc.identifier.citationKesäniemi, J., Jernfors, T., Lavrinienko, A., Kivisaari, K., Kiljunen, M., Mappes, T., & Watts, P. C. (2019). Exposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent. <i>Molecular Ecology</i>, <i>28</i>(20), 4620-4635. <a href="https://doi.org/10.1111/mec.15241" target="_blank">https://doi.org/10.1111/mec.15241</a>
dc.identifier.otherCONVID_32832014
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/65530
dc.description.abstractWildlife inhabiting environments contaminated by radionuclides face putative detrimental effects of exposure to ionizing radiation, with biomarkers such as an increase in DNA damage and/or oxidative stress commonly associated with radiation exposure. To examine the effects of exposure to radiation on gene expression in wildlife, we conducted a de novo RNA sequencing study of liver and spleen tissues from a rodent, the bank vole Myodes glareolus. Bank voles were collected from the Chernobyl Exclusion Zone (CEZ), where animals were exposed to elevated levels of radionuclides, and from uncontaminated areas near Kyiv, Ukraine. Counter to expectations, we did not observe a strong DNA damage response in animals exposed to radionuclides, although some signs of oxidative stress were identified. Rather, exposure to environmental radionuclides was associated with upregulation of genes involved in lipid metabolism and fatty acid oxidation in the livers – an apparent shift in energy metabolism. Moreover, using stable isotope analysis, we identified that fur from bank voles inhabiting the CEZ had enriched isotope values of nitrogen: such an increase is consistent with increased fatty acid metabolism, but also could arise from a difference in diet or habitat between the CEZ and elsewhere. In livers and spleens, voles inhabiting the CEZ were characterized by immunosuppression, such as impaired antigen processing, and activation of leukocytes involved in inflammatory responses. In conclusion, exposure to low dose environmental radiation impacts pathways associated with immunity and lipid metabolism, potentially as a stress‐induced coping mechanism.en
dc.format.mimetypeapplication/pdf
dc.languageeng
dc.language.isoeng
dc.publisherJohn Wiley & Sons
dc.relation.ispartofseriesMolecular Ecology
dc.rightsIn Copyright
dc.subject.otherDNA repair
dc.subject.otherMyodes glareolus
dc.subject.otherpollution
dc.subject.otherradionuclides
dc.subject.otherRNAseq
dc.subject.otherstable isotope
dc.titleExposure to environmental radionuclides is associated with altered metabolic and immunity pathways in a wild rodent
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201909174175
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologiafi
dc.contributor.oppiaineAkvaattiset tieteetfi
dc.contributor.oppiaineEcology and Evolutionary Biologyen
dc.contributor.oppiaineAquatic Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.description.reviewstatuspeerReviewed
dc.format.pagerange4620-4635
dc.relation.issn0962-1083
dc.relation.numberinseries20
dc.relation.volume28
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 John Wiley & Sons Ltd
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber268670
dc.subject.ysometsämyyrä
dc.subject.ysoDNA
dc.subject.ysosäteilybiologia
dc.subject.ysoaineenvaihdunta
dc.subject.ysoRNA
dc.subject.ysoimmuunijärjestelmä
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p513
jyx.subject.urihttp://www.yso.fi/onto/yso/p7690
jyx.subject.urihttp://www.yso.fi/onto/yso/p1781
jyx.subject.urihttp://www.yso.fi/onto/yso/p3066
jyx.subject.urihttp://www.yso.fi/onto/yso/p7689
jyx.subject.urihttp://www.yso.fi/onto/yso/p16041
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.datasethttps://doi.org/10.5061/dryad.j3c6r69
dc.relation.doi10.1111/mec.15241
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationPW and TM were funded by Academy of Finland (project numbers 287153 and 268670, respectively).


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