DNA methylation links prenatal smoking exposure to later life health outcomes in offspring
Wiklund, Petri; Karhunen, Ville; Richmond, Rebecca C.; Parmar, Priyanka; Rodriguez, Alina; De Silva, Maneka; Wielscher, Matthias; Rezwan, Faisal I.; Richardson, Tom G.; Veijola, Juha et al. (2019). DNA methylation links prenatal smoking exposure to later life health outcomes in offspring. Clinical Epigenetics, 11, 97. DOI: 10.1186/s13148-019-0683-4
Published in
Clinical EpigeneticsAuthors
Date
2019Copyright
© The Author(s) 2019
Background: Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship.
Methods: We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring.
Results: We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes.
Conclusions: DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.
...


Publisher
Biomed CentralISSN Search the Publication Forum
1868-7075Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/32133109
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [2059]
Additional information about funding
This project was supported by the Academy of Finland EGEA-project (285547), Biocenter, University of Oulu, Finland (75617), NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), ERDF European Regional Development Fund grant no. 539/2010 A31592, the EU H2020--PHC-2014 DynaHEALTH action (grant agreements no. 633595), EU H2020-HCO-2004 iHEALTH Action (grant agreement 643774), EU H2020-PHC-2014 ALEC Action (grant agreement no. 633212), EU H2020-SC1-2016-2017 LifeCycle Action (grant agreement no. 733206), EU H2020-MSCA-ITN-2016 CAPICE Action (grant agreement 721567) and MRC grant no. MR/M013138/1.

License
Related items
Showing items with similar title or keywords.
-
The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood
Westberg, Anna P.; Kautiainen, Hannu; Salonen, Minna K.; Kajantie, Eero; von Bonsdorff, Mikaela; Eriksson, Johan G. (Elsevier, 2019)Aims We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods This longitudinal birth ... -
Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring
Huizink, A. C.; Dick, D. M.; E, Sihvola; Pulkkinen, Lea; Rose, R. J.; Kaprio, J. (2007)Objective: Research in animals has shown that exposure to stressors during pregnancy is associated with offspring behavioural disorders. We aimed to study the effect of in utero exposure to the Chernobyl disaster in 1986, ... -
Does Arsenic Contamination Affect DNA Methylation Patterns in a Wild Bird Population? : An Experimental Approach
Laine, Veronika N.; Verschuuren, Mark; van Oers, Kees; Espín, Silvia; Sánchez-Virosta, Pablo; Eeva, Tapio; Ruuskanen, Suvi (American Chemical Society (ACS), 2021)Pollutants, such as toxic metals, negatively influence organismal health and performance, even leading to population collapses. Studies in model organisms have shown that epigenetic marks, such as DNA methylation, can be ... -
DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression
Mäki-Nevala, Satu; Valo, Satu; Ristimäki, Ari; Sarhadi, Virinder; Knuutila, Sakari; Nyström, Minna; Renkonen-Sinisalo, Laura; Lepistö, Anna; Mecklin, Jukka-Pekka; Peltomäki, Päivi (Elsevier BV, 2019)Background DNA mismatch repair (MMR) defects are a major factor in colorectal tumorigenesis in Lynch syndrome (LS) and 15% of sporadic cases. Some adenomas from carriers of inherited MMR gene mutations have intact MMR ... -
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
McCartney, Daniel L.; Min, Josine L.; Richmond, Rebecca C.; Lu, Ake T.; Sobczyk, Maria K.; Davies, Gail; Broer, Linda; Guo, Xiuqing; Jeong, Ayoung; Jung, Jeesun; Kasela, Silva; Katrinli, Seyma; Kuo, Pei-Lun; Matias-Garcia, Pamela R.; Mishra, Pashupati P.; Nygaard, Marianne; Palviainen, Teemu; Patki, Amit; Raffield, Laura M.; Ratliff, Scott M.; Richardson, Tom G.; Robinson, Oliver; Soerensen, Mette; Sun, Dianjianyi; Tsai, Pei-Chien; van der Zee, Matthijs D.; Walker, Rosie M.; Wang, Xiaochuan; Wang, Yunzhang; Xia, Rui; Xu, Zongli; Yao, Jie; Zhao, Wei; Correa, Adolfo; Boerwinkle, Eric; Dugué, Pierre-Antoine; Durda, Peter; Elliott, Hannah R.; Gieger, Christian; The Genetics of DNA Methylation Consortium; de Geus, Eco J. C.; Harris, Sarah E.; Hemani, Gibran; Imboden, Medea; Kähönen, Mika; Kardia, Sharon L. R.; Kresovich, Jacob K.; Li, Shengxu; Lunetta, Kathryn L.; Mangino, Massimo; Mason, Dan; McIntosh, Andrew M.; Mengel-From, Jonas; Moore, Ann Zenobia; Murabito, Joanne M.; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Ollikainen, Miina; Pankow, James S.; Pedersen, Nancy L.; Peters, Annette; Polidoro, Silvia; Porteous, David J.; Raitakari, Olli; Rich, Stephen S.; Sandler, Dale P.; Sillanpää, Elina; Smith, Alicia K.; Southey, Melissa C.; Strauch, Konstantin; Tiwari, Hemant; Tanaka, Toshiko; Tillin, Therese; Uitterlinden, Andre G.; Van Den Berg, David J.; van Dongen, Jenny; Wilson, James G.; Wright, John; Yet, Idil; Arnett, Donna; Bandinelli, Stefania; Bell, Jordana T.; Binder, Alexandra M.; Boomsma, Dorret I.; Chen, Wei; Christensen, Kaare; Conneely, Karen N.; Elliott, Paul; Ferrucci, Luigi; Fornage, Myriam; Hägg, Sara; Hayward, Caroline; Irvin, Marguerite; Kaprio, Jaakko; Lawlor, Deborah A.; Lehtimäki, Terho; Lohoff, Falk W.; Milani, Lili; Milne, Roger L.; Probst-Hensch, Nicole; Reiner, Alex P.; Ritz, Beate; Rotter, Jerome I.; Smith, Jennifer A.; Taylor, Jack A.; van Meurs, Joyce B. J.; Vineis, Paolo; Waldenberger, Melanie; Deary, Ian J.; Relton, Caroline L.; Horvath, Steve; Marioni, Riccardo E. (Biomed Central, 2021)Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation ...