Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring
Huizink, A. C., Dick, D. M., E, S., Pulkkinen, L., Rose, R. J., & Kaprio, J. (2007). Chernobyl exposure as stressor during pregnancy and hormone levels in adolescent offspring. Acta Psychiatrica Scandinavica, 116(6), 438-446. https://doi.org/10.1111/j.1600-0447.2007.01050.x
Julkaistu sarjassaActa Psychiatrica Scandinavica
© 2007 John Wiley & Sons A/S
Objective: Research in animals has shown that exposure to stressors during pregnancy is associated with offspring behavioural disorders. We aimed to study the effect of in utero exposure to the Chernobyl disaster in 1986, and maternal anxiety presumably associated with that exposure, on behaviour disorder observed at age 14. Method: Exposed (n = 232) and non‐exposed Finnish twins (n = 572) were compared. A semi‐structured interview was used to assess lifetime symptoms of depression, generalized anxiety disorder, attention deficit hyperactivity disorder, conduct disorder and oppositional defiant disorder symptoms. Results: Adolescents who were exposed from the second trimester in pregnancy onwards, had a 2.32‐fold risk (95% CI: 1.13–4.72) of having lifetime depression symptoms, an increased risk of fulfilling DSM‐III‐R criteria of a major depressive disorder (OR = 2.48, 95% CI: 1.06–5.7), and a 2.01‐fold risk (95% CI: 1.14–3.52) of having attention deficit hyperactivity disorder symptoms. Conclusion: Perturbations in fetal brain development during the second trimester may be associated with the increased prevalence of depressive and attention deficit hyperactivity disorder symptoms. ...
MetadataNäytä kaikki kuvailutiedot
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
Huizink, A.C.; Bartels, M.; Rose, R.J.; Pulkkinen, Lea; Eriksson, C.J.P.; Kaprio, J. (2008)Background: Animal research suggests a programming effect of prenatal stress in the fetal period, resulting in disruptions in behavioural and neuromotor development. Physiological changes that mediate these effects include ...
The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood Westberg, Anna P.; Kautiainen, Hannu; Salonen, Minna K.; Kajantie, Eero; von Bonsdorff, Mikaela; Eriksson, Johan G. (Elsevier, 2019)Aims We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account. Methods This longitudinal birth ...
Wiklund, Petri; Karhunen, Ville; Richmond, Rebecca C.; Parmar, Priyanka; Rodriguez, Alina; De Silva, Maneka; Wielscher, Matthias; Rezwan, Faisal I.; Richardson, Tom G.; Veijola, Juha; Herzig, Karl-Heinz; Holloway, John W.; Relton, Caroline L.; Sebert, Sylvain; Järvelin, Marjo-Riitta (Biomed Central, 2019)Background: Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship. Methods: We ...
Westberg, Anna P.; Salonen, Minna K.; von Bonsdorff, Mikaela; Osmond, Clive; Kajantie, Eero; Eriksson, Johan G. (European Respiratory Society, 2018)
A Smartphone App to Promote Healthy Weight Gain, Diet, and Physical Activity During Pregnancy (HealthyMoms) : Protocol for a Randomized Controlled Trial Henriksson, Pontus; Sandborg, Johanna; Blomberg, Marie; Alexandrou, Christina; Maddison, Ralph; Silfvernagel, Kristin; Henriksson, Hanna; Leppänen, Marja; Migueles, Jairo H.; Widman, Linnea; Thomas, Kristin; Lagerros, Ylva Trolle; Löf, Marie (JMIR Publications Inc, 2019)Background: Excessive gestational weight gain is common and associated with adverse outcomes both in the short and long term. Although traditional lifestyle-based interventions have shown to mitigate excess gestational ...