Show simple item record

dc.contributor.authorHaapanen, M. J.
dc.contributor.authorPerälä, M. M.
dc.contributor.authorSalonen, M. K.
dc.contributor.authorKajantie, E.
dc.contributor.authorSimonen, M.
dc.contributor.authorPohjolainen, P.
dc.contributor.authorEriksson, J. G.
dc.contributor.authorvon Bonsdorff, Mikaela
dc.date.accessioned2019-04-24T10:09:30Z
dc.date.available2019-04-24T10:09:30Z
dc.date.issued2018
dc.identifier.citationHaapanen, M. J., Perälä, M.M., Salonen, M. K., Kajantie, E., Simonen, M., Pohjolainen, P., Eriksson, J. G., & von Bonsdorff, M. (2018). Early life determinants of frailty in old age : the Helsinki Birth Cohort Stud. <i>Age and Ageing</i>, <i>47</i>(4), 569-575. <a href="https://doi.org/10.1093/ageing/afy052" target="_blank">https://doi.org/10.1093/ageing/afy052</a>
dc.identifier.otherCONVID_28004926
dc.identifier.otherTUTKAID_77382
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/63597
dc.description.abstractBackground there is evidence suggesting that several chronic diseases have their origins in utero and that development taking place during sensitive periods may affect the aging process. We investigated whether early life determinants would be associated with frailty in old age. Methods at a mean age of 71 years, 1,078 participants belonging to the Helsinki Birth Cohort Study were assessed for frailty according to the Fried frailty criteria. Early life measurements (birth weight, length, mother body mass index [BMI] and parity) were obtained from birth, child welfare and school health records. Multinomial regression analysis was used to assess the association between early life determinants and frailty in old age. Results weight, length and BMI at birth were all inversely associated with frailty in old age. A 1 kg increase in birth weight was associated with a lower relative risk ratio (RRR) of frailty (age and sex-adjusted RRR = 0.40, 95% CI: 0.19, 0.82) compared to non-frailty. Associations persisted after adjusting for several confounding factors. Compared to cohort members in the upper middle class, those who as adults worked as manual workers or belonged to the lower middle class, were at an increased risk of frailty. Conclusions those who were small at birth were at an increased risk of developing frailty in old age, suggesting that frailty is at least partly programmed in early life. A less privileged socioeconomic status in adulthood was associated with an increased risk of frailty in old age.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofseriesAge and Ageing
dc.rightsIn Copyright
dc.subject.otherfrailty
dc.subject.otherlife course
dc.subject.otherfetal programming
dc.subject.otherolder people
dc.titleEarly life determinants of frailty in old age : the Helsinki Birth Cohort Stud
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201904232232
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-04-23T06:15:31Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange569-575
dc.relation.issn0002-0729
dc.relation.numberinseries4
dc.relation.volume47
dc.type.versionacceptedVersion
dc.rights.copyright© The Authors 2018.
dc.rights.accesslevelopenAccessfi
dc.subject.ysohauraus-raihnausoireyhtymä
dc.subject.ysosyntymäpaino
dc.subject.ysosikiö
dc.subject.ysoikääntyminen
dc.subject.ysoterveys
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p28376
jyx.subject.urihttp://www.yso.fi/onto/yso/p21306
jyx.subject.urihttp://www.yso.fi/onto/yso/p19931
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p2762
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1093/ageing/afy052


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

In Copyright
Except where otherwise noted, this item's license is described as In Copyright