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dc.contributor.authorKesäniemi, Jenni
dc.contributor.authorLavrinienko, Anton
dc.contributor.authorTukalenko, Eugene
dc.contributor.authorBoratyński, Zbyszek
dc.contributor.authorKivisaari, Kati
dc.contributor.authorMappes, Tapio
dc.contributor.authorMilinevsky, Gennadi
dc.contributor.authorMøller, Anders Pape
dc.contributor.authorMousseau, Timothy A.
dc.contributor.authorWatts, Philip
dc.date.accessioned2019-02-12T13:11:39Z
dc.date.available2019-02-12T13:11:39Z
dc.date.issued2019fi
dc.identifier.citationKesäniemi, J., Lavrinienko, A., Tukalenko, E., Boratyński, Z., Kivisaari, K., Mappes, T., . . . Watts, P. (2019). Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length. <em>Scientific Reports</em>, 9, 850. <a href="https://doi.org/10.1038/s41598-018-37164-8">doi:10.1038/s41598-018-37164-8</a>fi
dc.identifier.otherTUTKAID_80499
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/62762
dc.description.abstractTelomeres, the protective structures at the ends of chromosomes, can be shortened when individuals are exposed to stress. In some species, the enzyme telomerase is expressed in adult somatic tissues, and potentially protects or lengthens telomeres. Telomeres can be damaged by ionizing radiation and oxidative stress, although the effect of chronic exposure to elevated levels of radiation on telomere maintenance is unknown for natural populations. We quantified telomerase expression and telomere length (TL) in different tissues of the bank vole Myodes glareolus, collected from the Chernobyl Exclusion Zone, an environment heterogeneously contaminated with radionuclides, and from uncontaminated control sites elsewhere in Ukraine. Inhabiting the Chernobyl Exclusion Zone was associated with reduced TL in the liver and testis, and upregulation of telomerase in brain and liver. Thus upregulation of telomerase does not appear to associate with longer telomeres but may reflect protective functions other than telomere maintenance or an attempt to maintain shorter telomeres in a stressful environment. Tissue specific differences in the rate of telomere attrition and apparent radiosensitivity weaken the intra-individual correlation in telomere length among tissues in voles exposed to radionuclides. Our data show that ionizing radiation alters telomere homeostasis in wild animal populations in tissue specific ways.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports
dc.rightsCC BY 4.0
dc.subject.othersäteilybiologiafi
dc.subject.otherionisoiva säteilyfi
dc.subject.otherkudoksetfi
dc.subject.othertelomeeritfi
dc.subject.othermetsämyyräfi
dc.subject.otherradiobiologyfi
dc.subject.otherionising radiationfi
dc.subject.othertissuesfi
dc.subject.othertelomeresfi
dc.subject.otherbank volefi
dc.titleExposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere lengthfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201901301366
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosThe Department of Biological and Environmental Scienceen
dc.contributor.oppiaineEkologia ja evoluutiobiologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-01-30T16:15:05Z
dc.description.reviewstatuspeerReviewed
dc.relation.issn2045-2322
dc.relation.numberinseries0
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors, 2019
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41598-018-37164-8


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