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dc.contributor.authorLensu, Sanna
dc.contributor.authorWaselius, Tomi
dc.contributor.authorPenttonen, Markku
dc.contributor.authorNokia, Miriam
dc.date.accessioned2019-01-07T08:45:04Z
dc.date.available2020-01-01T22:35:37Z
dc.date.issued2019
dc.identifier.citationLensu, S., Waselius, T., Penttonen, M., & Nokia, M. (2019). Dentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separation. <i>Journal of Neurophysiology</i>, <i>121</i>(1), 131-139. <a href="https://doi.org/10.1152/jn.00696.2018" target="_blank">https://doi.org/10.1152/jn.00696.2018</a>
dc.identifier.otherCONVID_28724635
dc.identifier.otherTUTKAID_79539
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60926
dc.description.abstractHippocampal dentate spikes (DSs) are short-duration, large-amplitude fluctuations in hilar local field potentials and take place while resting and sleeping. During DSs, dentate gyrus granule cells increase firing while CA1 pyramidal cells decrease firing. Recent findings suggest DSs play a significant role in memory consolidation after training on a hippocampus-dependent, nonspatial associative learning task. Here, we aimed to find out whether DSs are important in other types of hippocampus-dependent learning tasks as well. To this end, we trained adult male Sprague-Dawley rats in a spatial reference memory task, a fixed interval task, and a pattern separation task. During a rest period immediately after each training session, we either let neural activity to take place as usual, timed electrical stimulation of the ventral hippocampal commissure (vHC) to immediately follow DSs, or applied the vHC stimulation during a random neural state. We found no effect of vHC stimulation on performance in the spatial reference memory task or in the fixed interval task. Surprisingly, vHC stimulation, especially contingent on DSs, improved performance in the pattern separation task. In conclusion, the behavioral relevance of hippocampal processing and DSs seems to depend on the task at hand. It could be that in an intact brain, offline memory consolidation by default involves associating neural representations of temporally separate but related events. In some cases this might be beneficial for adaptive behavior in the future (associative learning), while in other cases it might not (pattern separation).en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Neurophysiology
dc.rightsIn Copyright
dc.subject.otherdentate spike
dc.subject.othermemory consolidation
dc.titleDentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separation
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201901021001
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiainePsykologiafi
dc.contributor.oppiaineLiikuntafysiologiafi
dc.contributor.oppiaineMonitieteinen aivotutkimuskeskusfi
dc.contributor.oppiainePsychologyen
dc.contributor.oppiaineExercise Physiologyen
dc.contributor.oppiaineCentre for Interdisciplinary Brain Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-01-02T07:15:13Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange131-139
dc.relation.issn0022-3077
dc.relation.numberinseries1
dc.relation.volume121
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 the American Physiological Society
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber284155
dc.relation.grantnumber286384
dc.relation.grantnumber275954
dc.relation.grantnumber316966
dc.subject.ysohippokampus
dc.subject.ysomuisti (kognitio)
dc.subject.ysooppiminen
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p21117
jyx.subject.urihttp://www.yso.fi/onto/yso/p2607
jyx.subject.urihttp://www.yso.fi/onto/yso/p2945
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1152/jn.00696.2018
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
dc.relation.funderAcademy of Finlanden
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramAkatemiatutkijan tehtävä, SAfi
jyx.fundingprogramAkatemiahanke, SAfi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundingprogramResearch post as Academy Research Fellow, AoFen
jyx.fundingprogramAcademy Project, AoFen
jyx.fundinginformationThis study was supported by the Academy of Finland (grant nos. 275954, 284155 and, 286384 to M. S. Nokia; 316966 to M. Penttonen).


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