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dc.contributor.authorLensu, Sanna
dc.contributor.authorWaselius, Tomi
dc.contributor.authorPenttonen, Markku
dc.contributor.authorNokia, Miriam
dc.date.accessioned2019-01-07T08:45:04Z
dc.date.available2020-01-01T22:35:37Z
dc.date.issued2019fi
dc.identifier.citationLensu, S., Waselius, T., Penttonen, M., & Nokia, M. (2019). Dentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separation. <em>Journal of Neurophysiology</em>, 121 (1), 131-139. <a href="https://doi.org/10.1152/jn.00696.2018">doi:10.1152/jn.00696.2018</a>fi
dc.identifier.otherTUTKAID_79539
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/60926
dc.description.abstractHippocampal dentate spikes (DSs) are short-duration, large-amplitude fluctuations in hilar local field potentials and take place while resting and sleeping. During DSs, dentate gyrus granule cells increase firing while CA1 pyramidal cells decrease firing. Recent findings suggest DSs play a significant role in memory consolidation after training on a hippocampus-dependent, nonspatial associative learning task. Here, we aimed to find out whether DSs are important in other types of hippocampus-dependent learning tasks as well. To this end, we trained adult male Sprague-Dawley rats in a spatial reference memory task, a fixed interval task, and a pattern separation task. During a rest period immediately after each training session, we either let neural activity to take place as usual, timed electrical stimulation of the ventral hippocampal commissure (vHC) to immediately follow DSs, or applied the vHC stimulation during a random neural state. We found no effect of vHC stimulation on performance in the spatial reference memory task or in the fixed interval task. Surprisingly, vHC stimulation, especially contingent on DSs, improved performance in the pattern separation task. In conclusion, the behavioral relevance of hippocampal processing and DSs seems to depend on the task at hand. It could be that in an intact brain, offline memory consolidation by default involves associating neural representations of temporally separate but related events. In some cases this might be beneficial for adaptive behavior in the future (associative learning), while in other cases it might not (pattern separation).fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesJournal of Neurophysiology
dc.rightsIn Copyright
dc.subject.otherhippokampusfi
dc.subject.otheroppiminenfi
dc.subject.othermuisti (kognitio)fi
dc.subject.otherhippocampusfi
dc.subject.otherdentate spikefi
dc.subject.otherlearningfi
dc.subject.othermemory consolidationfi
dc.titleDentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separationfi
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201901021001
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineLiikuntafysiologia
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2019-01-02T07:15:13Z
dc.description.reviewstatuspeerReviewed
dc.format.pagerange131-139
dc.relation.issn0022-3077
dc.relation.numberinseries1
dc.relation.volume121
dc.type.versionacceptedVersion
dc.rights.copyright© 2019 the American Physiological Society
dc.rights.accesslevelopenAccessfi
dc.format.contentfulltext
dc.rights.urlhttp://rightsstatements.org/page/InC/1.0/?language=en
dc.relation.doi10.1152/jn.00696.2018


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