Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning
Nokia, M., Mikkonen, J., Penttonen, M., & Wikgren, J. (2012). Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning. Frontiers in Behavioral Neuroscience, 6(84). https://doi.org/10.3389/fnbeh.2012.00084
Published inFrontiers in Behavioral Neuroscience
DisciplinePsykologiaMonitieteinen aivotutkimuskeskusHyvinvoinnin tutkimuksen yhteisöPsychologyCentre for Interdisciplinary Brain ResearchSchool of Wellbeing
© 2012 Nokia, Mikkonen, Penttonen and Wikgren. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Oscillations in hippocampal local-field potentials (LFPs) reflect the crucial involvement of the hippocampus in memory trace formation: theta (4–8 Hz) oscillations and ripples (~200 Hz) occurring during sharp waves are thought to mediate encoding and consolidation, respectively. During sharp wave-ripple complexes (SPW-Rs), hippocampal cell firing closely follows the pattern that took place during the initial experience, most likely reflecting replay of that event. Disrupting hippocampal ripples using electrical stimulation either during training in awake animals or during sleep after training retards spatial learning. Here, adult rabbits were trained in trace eyeblink conditioning, a hippocampus-dependent associative learning task. A bright light was presented to the animals during the inter-trial interval (ITI), when awake, either during SPW-Rs or irrespective of their neural state. Learning was particularly poor when the light was presented following SPW-Rs. While the light did not disrupt the ripple itself, it elicited a theta-band oscillation, a state that does not usually coincide with SPW-Rs. Thus, it seems that consolidation depends on neuronal activity within and beyond the hippocampus taking place immediately after, but by no means limited to, hippocampal SPW-Rs. ...
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Except where otherwise noted, this item's license is described as © 2012 Nokia, Mikkonen, Penttonen and Wikgren. This is an open-access article distributed under the terms of the Creative Commons Attribution License.
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Nokia, Miriam (University of Jyväskylä, 2009)
Dentate spikes and learning : Disrupting hippocampal function during memory consolidation can improve pattern separation Lensu, Sanna; Waselius, Tomi; Penttonen, Markku; Nokia, Miriam (American Physiological Society, 2019)Hippocampal dentate spikes (DSs) are short-duration, large-amplitude fluctuations in hilar local field potentials and take place while resting and sleeping. During DSs, dentate gyrus granule cells increase firing while CA1 ...
Hippocampal theta activity is selectively associated with contingency detection but not discrimination in rabbit discrimination-reversal eyeblink conditioning Nokia, Miriam; Wikgren, Jan (Wiley, 2010)The relative power of the hippocampal theta-band (∼6 Hz) activity (theta ratio) is thought to reflect a distinct neural state and has been shown to affect learning rate in classical eyeblink conditioning in rabbits. We ...
Hippocampal ripple-contingent training accelerates trace eyeblink conditioning and retards extinction in rabbits Nokia, Miriam; Penttonen, Markku; Wikgren, Jan (Society for Neuroscience, 2010)There are at least two distinct oscillatory states of the hippocampus that are related to distinct behavioral patterns. Theta (4–12 Hz) oscillation has been suggested to indicate selective attention during which the animal ...
Waselius, Tomi; Pöllänen, Eveliina; Wikgren, Jan; Penttonen, Markku; Nokia, Miriam (Elsevier BV, 2017)Hippocampal theta oscillations (3–12 Hz) play a prominent role in learning. It has been suggested that encoding and retrieval of memories are supported by different phases of the theta cycle. Our previous study on trace ...