dc.contributor.author | Kovanen, Vuokko | |
dc.contributor.author | Aukee, Pauliina | |
dc.contributor.author | Kokko, Katja | |
dc.contributor.author | Finni Juutinen, Taija | |
dc.contributor.author | Tarkka, Ina | |
dc.contributor.author | Tammelin, Tuija | |
dc.contributor.author | Kujala, Urho | |
dc.contributor.author | Sipilä, Sarianna | |
dc.contributor.author | Laakkonen, Eija | |
dc.date.accessioned | 2018-08-22T10:16:10Z | |
dc.date.available | 2018-08-22T10:16:10Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Kovanen, V., Aukee, P., Kokko, K., Finni Juutinen, T., Tarkka, I., Tammelin, T., Kujala, U., Sipilä, S., & Laakkonen, E. (2018). Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-related differences in blood count. <i>Menopause: The Journal of The North American Menopause Society</i>, <i>25</i>(9), 1020-1032. <a href="https://doi.org/10.1097/GME.0000000000001117" target="_blank">https://doi.org/10.1097/GME.0000000000001117</a> | |
dc.identifier.other | CONVID_28047606 | |
dc.identifier.other | TUTKAID_77610 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/59306 | |
dc.description.abstract | Objective:
The multidisciplinary Estrogenic Regulation of Muscle Apoptosis (ERMA) study was designed to
reveal how hormonal differences over the menopausal stages affect the physiological and psychological functioning of middle-aged women. This paper describes the protocol and nonrespondent analysis of ERMA and novel findings on menopausal differences in blood count variables and their association with female sex hormones.
Methods:
Women aged 47 to 55 years were assigned to pre, early peri, late peri, and postmenopausal groups
based on follicle-stimulating hormone (FSH) and bleeding diary. Multivariate linear regression models were
constructed to estimate the association of 17b-estradiol (E2) and FSH with the blood count variables.
Results:
In all, 3,064 women returned the prequestionnaire (ERMA phase one), 1,393 donated blood samples and
were assigned to the relevant menopausal group (phase two), and 914 completed phase three, which included
physiological and psychological measurements. Nonrespondents were more likely than respondents to be obese,
whereas the menopausal groups showed no mean differences in body mass index. Blood count variables, while being
within clinical reference values, showed significant differences between groups. E2 and FSH were associated with
the white blood cell (WBC) count and neutrophil-to-lymphocyte ratio.
Conclusions:
The ERMA study was successful in recruiting and characterizing the menopausal status of a cohort
sample of middle-aged women. The significant group differences found in the blood count variables and their
associations with E2 and FSH verifies menopause-associated changes in WBC composition potentially being an
early sign of low-grade inflammation that may develop later in life.
Key Words:
17b-Estradiol – Blood viscosity – FSH – Leucocyte count – Menopausal status – Neutrophil-
to-lymphocyte ratio. | fi |
dc.format.mimetype | application/pdf | |
dc.language | eng | |
dc.language.iso | eng | |
dc.publisher | Lippincott Williams & Wilkins | |
dc.relation.ispartofseries | Menopause: The Journal of The North American Menopause Society | |
dc.rights | CC BY-NC-ND 4.0 | |
dc.subject.other | 17b-Estradiol | |
dc.subject.other | blood viscosity | |
dc.subject.other | FSH | |
dc.subject.other | leucocyte count | |
dc.subject.other | menopausal status | |
dc.subject.other | neutrophil-to-lymphocyte ratio | |
dc.title | Design and protocol of Estrogenic Regulation of Muscle Apoptosis (ERMA) study with 47 to 55-year-old women's cohort : novel results show menopause-related differences in blood count | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-201808223907 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Biomekaniikka | fi |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Liikuntalääketiede | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Biomechanics | en |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Sports and Exercise Medicine | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.date.updated | 2018-08-22T09:15:09Z | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 1020-1032 | |
dc.relation.issn | 1072-3714 | |
dc.relation.numberinseries | 9 | |
dc.relation.volume | 25 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2018 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 675003 | |
dc.relation.grantnumber | 675003 | |
dc.relation.grantnumber | 275323 | |
dc.relation.grantnumber | 309504 | |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/H2020/675003/EU//PANINI | |
dc.subject.yso | estradioli | |
dc.subject.yso | valkosolut | |
dc.subject.yso | estrogeenit | |
dc.subject.yso | ohjelmoitunut solukuolema | |
dc.subject.yso | vaihdevuodet | |
dc.subject.yso | lihaskunto | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p19425 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p18721 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p16792 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p6280 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p17397 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p7382 | |
dc.rights.url | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.relation.doi | 10.1097/GME.0000000000001117 | |
dc.relation.funder | Euroopan komissio | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | European Commission | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
jyx.fundingprogram | MSCA Marie Skłodowska-Curie Actions, H2020 | fi |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundingprogram | MSCA Marie Skłodowska-Curie Actions, H2020 | en |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundinginformation | This research is supported by the Academy of Finland (VK: Grant nro 275323, EKL: nro 309504), PANINI (SS: Horizon 2020-the Framework Programme for Research and Innovation, Marie Sklodowska-Curie Actions, ITN, ref 15-0667), and the Juho Vainio Foundation (EKL). Financial disclosure/conflicts of interest: None reported. | |
datacite.isSupplementedBy.doi | 10.17011/jyx/dataset/83491 | |
datacite.isSupplementedBy | Laakkonen, Eija; Kovanen, Vuokko; Sipilä, Sarianna. (2022). <i>Data from Estrogenic Regulation of Muscle Apoptosis (ERMA) study</i>. University of Jyväskylä. <a href="https://doi.org/10.17011/jyx/dataset/83491" target="_blank">https://doi.org/10.17011/jyx/dataset/83491</a>. <a href="http://urn.fi/URN:NBN:fi:jyu-202210074820">https://urn.fi/URN:NBN:fi:jyu-202210074820</a> | |
dc.type.okm | A1 | |