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dc.contributor.authorMerikanto, Ilona
dc.contributor.authorLaakso, Jouni
dc.contributor.authorKaitala, Veijo
dc.date.accessioned2018-06-26T07:01:31Z
dc.date.available2018-06-26T07:01:31Z
dc.date.issued2018
dc.identifier.citationMerikanto, I., Laakso, J., & Kaitala, V. (2018). Outside-host phage therapy as a biological control against environmental infectious diseases. <i>Theoretical Biology and Medical Modelling</i>, <i>15</i>, Article 7. <a href="https://doi.org/10.1186/s12976-018-0079-8" target="_blank">https://doi.org/10.1186/s12976-018-0079-8</a>
dc.identifier.otherCONVID_28106475
dc.identifier.otherTUTKAID_77933
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/58733
dc.description.abstractBackground Environmentally growing pathogens present an increasing threat for human health, wildlife and food production. Treating the hosts with antibiotics or parasitic bacteriophages fail to eliminate diseases that grow also in the outside-host environment. However, bacteriophages could be utilized to suppress the pathogen population sizes in the outside-host environment in order to prevent disease outbreaks. Here, we introduce a novel epidemiological model to assess how the phage infections of the bacterial pathogens affect epidemiological dynamics of the environmentally growing pathogens. We assess whether the phage therapy in the outside-host environment could be utilized as a biological control method against these diseases. We also consider how phage-resistant competitors affect the outcome, a common problem in phage therapy. The models give predictions for the scenarios where the outside-host phage therapy will work and where it will fail to control the disease. Parameterization of the model is based on the fish columnaris disease that causes significant economic losses to aquaculture worldwide. However, the model is also suitable for other environmentally growing bacterial diseases. Results Transmission rates of the phage determine the success of infectious disease control, with high-transmission phage enabling the recovery of the host population that would in the absence of the phage go asymptotically extinct due to the disease. In the presence of outside-host bacterial competition between the pathogen and phage-resistant strain, the trade-off between the pathogen infectivity and the phage resistance determines phage therapy outcome from stable coexistence to local host extinction. Conclusions We propose that the success of phage therapy strongly depends on the underlying biology, such as the strength of trade-off between the pathogen infectivity and the phage-resistance, as well as on the rate that the phages infect the bacteria. Our results indicate that phage therapy can fail if there are phage-resistant bacteria and the trade-off between pathogen infectivity and phage resistance does not completely inhibit the pathogen infectivity. Also, the rate that the phages infect the bacteria should be sufficiently high for phage-therapy to succeed.fi
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherBioMed Central
dc.relation.ispartofseriesTheoretical Biology and Medical Modelling
dc.rightsCC BY 4.0
dc.subject.otherbacteriophage
dc.subject.otherColumnaris disease
dc.subject.otherenvironmental opportunist
dc.subject.otherflavobacterium
dc.subject.otherhost-parasite interaction
dc.subject.otherSI model
dc.titleOutside-host phage therapy as a biological control against environmental infectious diseases
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201806133182
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.oppiaineBiologisten vuorovaikutusten huippututkimusyksikköfi
dc.contributor.oppiaineCentre of Excellence in Biological Interactions Researchen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-06-13T15:15:07Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn1742-4682
dc.relation.numberinseries0
dc.relation.volume15
dc.type.versionpublishedVersion
dc.rights.copyright© The Authors 2018
dc.rights.accesslevelopenAccessfi
dc.subject.ysokalataudit
dc.subject.ysoinfektiot
dc.subject.ysobiologinen torjunta
dc.subject.ysofagiterapia
dc.subject.ysobakteriofagit
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p46
jyx.subject.urihttp://www.yso.fi/onto/yso/p7316
jyx.subject.urihttp://www.yso.fi/onto/yso/p15969
jyx.subject.urihttp://www.yso.fi/onto/yso/p29496
jyx.subject.urihttp://www.yso.fi/onto/yso/p25303
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1186/s12976-018-0079-8
dc.type.okmA1


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