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dc.contributor.authorKangas, Reeta
dc.contributor.authorMorsiani, Cristina
dc.contributor.authorPizza, Grazia
dc.contributor.authorLanzarini, Catia
dc.contributor.authorAukee, Pauliina
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorFranceschi, Claudio
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorCapri, Miriam
dc.date.accessioned2018-02-13T06:14:32Z
dc.date.available2018-02-13T06:14:32Z
dc.date.issued2018
dc.identifier.citationKangas, R., Morsiani, C., Pizza, G., Lanzarini, C., Aukee, P., Kaprio, J., Sipilä, S., Franceschi, C., Kovanen, V., Laakkonen, E., & Capri, M. (2018). Menopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement. <i>Oncotarget</i>, <i>9</i>(2), 2279-2294. <a href="https://doi.org/10.18632/oncotarget.23406" target="_blank">https://doi.org/10.18632/oncotarget.23406</a>
dc.identifier.otherCONVID_27811290
dc.identifier.otherTUTKAID_76325
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/57054
dc.description.abstractTissue-specific effects of 17β-estradiol are delivered via both estrogen receptors and microRNAs (miRs). Menopause is known to affect the whole-body fat distribution in women. This investigation aimed at identifying menopause- and hormone replacement therapy (HRT)-associated miR profiles and miR targets in subcutaneous abdominal adipose tissue and serum from the same women. A discovery phase using array technology was performed in 13 women, including monozygotic twin pairs discordant for HRT and premenopausal young controls. Seven miRs, expressed in both adipose tissue and serum, were selected for validation phase in 34 women from a different cohort. An age/menopause-related increase of miRs-16-5p, -451a, -223-3p, -18a-5p, -19a-3p,-486-5p and -363-3p was found in the adipose tissue, but not in serum. MiR-19a-3p, involved in adipocyte development and estrogen signaling, resulted to be higher in HRT users in comparison with non-users. Among the identified targets, AKT1, BCL-2 and BRAF proteins showed lower expression in both HRT and No HRT users in comparison with premenopausal women. Unexpectedly, ESR1 protein expression was not modified although its mRNA was lower in No HRT users compared to premenopausal women and HRT users. Thus, both HRT and menopause appear to affect adipose tissue homeostasis via miR-mediated mechanism.
dc.language.isoeng
dc.publisherImpact Journals
dc.relation.ispartofseriesOncotarget
dc.subject.otherestrogeenihoito
dc.subject.othermicroRNAs
dc.subject.othermiR-19a-3p
dc.subject.otheradipose tissue
dc.subject.otheraging
dc.subject.otherestrogen therapy
dc.titleMenopause and adipose tissue: miR-19a-3p is sensitive to hormonal replacement
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201802121472
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-02-12T13:15:07Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2279-2294
dc.relation.issn1949-2553
dc.relation.numberinseries2
dc.relation.volume9
dc.type.versionpublishedVersion
dc.rights.copyright© Kangas et al., 2017. This is an open access article distributed under the terms of the Creative Commons License.
dc.rights.accesslevelopenAccessfi
dc.subject.ysovaihdevuodet
dc.subject.ysoikääntyminen
dc.subject.ysorasvakudokset
dc.subject.ysoestrogeenit
dc.subject.ysohormonit
dc.subject.ysohormonihoito
jyx.subject.urihttp://www.yso.fi/onto/yso/p17397
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p24382
jyx.subject.urihttp://www.yso.fi/onto/yso/p16792
jyx.subject.urihttp://www.yso.fi/onto/yso/p2589
jyx.subject.urihttp://www.yso.fi/onto/yso/p980
dc.rights.urlhttps://creativecommons.org/licenses/by/3.0/
dc.relation.doi10.18632/oncotarget.23406
dc.type.okmA1


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© Kangas et al., 2017. This is an open access article distributed under the terms of the Creative Commons License.
Except where otherwise noted, this item's license is described as © Kangas et al., 2017. This is an open access article distributed under the terms of the Creative Commons License.