Show simple item record

dc.contributor.authorPekkala, Satu
dc.contributor.authorLensu, Sanna
dc.contributor.authorNokia, Miriam
dc.contributor.authorVanhatalo, Sanja
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2018-01-29T09:35:08Z
dc.date.available2018-12-02T22:35:38Z
dc.date.issued2017
dc.identifier.citationPekkala, S., Lensu, S., Nokia, M., Vanhatalo, S., Koch, L. G., Britton, S. L., & Kainulainen, H. (2017). Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings. <em>Physiological Genomics</em>, 49 (12), 733-746. <a href="https://doi.org/10.1152/physiolgenomics.00081.2017">doi:10.1152/physiolgenomics.00081.2017</a>
dc.identifier.otherTUTKAID_75383
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/56935
dc.description.abstractHost genetic factors affecting the gut microbiome play an important role in obesity, yet limited attention has been paid on the host genetic factors linked to physical fitness in modifying the microbiome. This study determined whether sibling-matched pairs of rats selectively bred for high (HCR) and low (LCR) aerobic capacity differ in their microbiome age-dependently and which taxa associate with differential in metabolism. Several taxa in young adult rats (hereafter young) linked to inherited aerobic capacity, while in older adult (hereafter old) rats most of the differences between the lines associated with body weight. Despite the absence of weight differential between LCR and HCR when young, the LCR microbiome contained more Actinobacteria, Veillonellaceae, Coriobacteriaceae, Phascolarctobacterium, and Ruminococcus; taxa previously linked to obesity. This raises the question whether the microbiome contributes to the later development of obesity in LCR. Age-related differences were detected in almost all taxa in both rat lines. The young HCR measured higher for serum glycerol and free fatty-acids and lower for cholesterol, HDL, LDL, and triglycerides than LCR. The old HCR differed from the old LCR by lower LDL. Several metabolites, including LDL, are associated age and genetic background-dependently with the microbiome, which might explain the metabolic differences between the lines. While old lines did not differ in visceral adipose tissue gene expression, the young HCR expressed more inflammatory genes than LCR, and several taxa including Proteobacteria associated with these genes. In conclusion, intrinsic aerobic capacity governs the microbiome, which may influence body weight, metabolism, and gene expression.
dc.language.isoeng
dc.publisherAmerican Physiological Society
dc.relation.ispartofseriesPhysiological Genomics
dc.subject.otheraerobinen suorituskyky
dc.subject.othergeeniekspressio
dc.subject.otheraineenvaihdunta
dc.subject.otherrasva-arvot
dc.subject.othersuolisto
dc.subject.othermikrobisto
dc.subject.otheraerobic capacity
dc.subject.othergene expression
dc.subject.othergut microbiota
dc.subject.othermetabolism
dc.subject.otherlipid metabolism
dc.subject.otherfatty acid levels
dc.subject.otherintestines
dc.subject.othermicrobiome
dc.titleIntrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201801291353
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.laitosDepartment of Psychologyen
dc.contributor.oppiaineLiikuntafysiologia
dc.contributor.oppiainePsykologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2018-01-29T07:15:08Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange733-746
dc.relation.issn1094-8341
dc.relation.volume49
dc.type.versionacceptedVersion
dc.rights.copyright© 2017 the American Physiological Society. This is a final draft version of an article whose final and definitive form has been published by the American Physiological Society. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.relation.doi10.1152/physiolgenomics.00081.2017


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record