Evolved high aerobic capacity has context-specific effects on gut microbiota
Hanhimäki, E., Watts, P. C., Koskela, E., Koteja, P., Mappes, T., & Hämäläinen, A. M. (2022). Evolved high aerobic capacity has context-specific effects on gut microbiota. Frontiers in Ecology and Evolution, 10, Article 934164. https://doi.org/10.3389/fevo.2022.934164
Julkaistu sarjassa
Frontiers in Ecology and EvolutionTekijät
Päivämäärä
2022Oppiaine
Ekologia ja evoluutiobiologiaResurssiviisausyhteisöEcology and Evolutionary BiologySchool of Resource WisdomTekijänoikeudet
© 2022 Hanhimäki, Watts, Koskela, Koteja, Mappes and Hämäläinen.
Gut microbiota is expected to coevolve with the host's physiology and may play a role in adjusting the host's energy metabolism to suit the host's environment. To evaluate the effects of both evolved host metabolism and the environmental context in shaping the gut microbiota, we used a unique combination of (1) experimental evolution to create selection lines for a fast metabolism and (2) a laboratory-to-field translocation study. Mature bank voles Myodes glareolus from lines selected for high aerobic capacity (A lines) and from unselected control (C lines) were released into large (0.2 ha) outdoor enclosures for longitudinal monitoring. To examine whether the natural environment elicited a similar or more pronounced impact on the gut microbiota of the next generation, we also sampled the field-reared offspring. The gut microbiota were characterized using 16S rRNA amplicon sequencing of fecal samples. The artificial selection for fast metabolism had minimal impact on the gut microbiota in laboratory conditions but in field conditions, there were differences between the selection lines (A lines vs. C lines) in the diversity, community, and resilience of the gut microbiota. Notably, the selection lines differed in the less abundant bacteria throughout the experiment. The lab-to-field transition resulted in an increase in alpha diversity and an altered community composition in the gut microbiota, characterized by a significant increase in the relative abundance of Actinobacteria and a decrease of Patescibacteria. Also, the selection lines showed different temporal patterns in changes in microbiota composition, as the average gut microbiota alpha diversity of the C lines, but not A lines, was temporarily reduced during the initial transition to the field. In surviving young voles, the alpha diversity of gut microbiota was significantly higher in A-line than C-line voles. These results indicate that the association of host metabolism and gut microbiota is context-specific, likely mediated by behavioral or physiological modifications in response to the environment.
...
Julkaisija
Frontiers Media SAISSN Hae Julkaisufoorumista
2296-701XAsiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/151609755
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
KV-yhteishanke, SALisätietoja rahoituksesta
The study was funded by National Science Center OPUS 15 no. 2018/29/B/NZ8/01924 and Finnish Cultural Foundation to AH. Personal funding from Societas pro Fauna et Flora Fennica and Oulun Luonnonystäväin Yhdistys was granted to EH. This research was funded also through the 2017-2018 Belmont Forum and BiodivERsA joint call for research proposals, under the BiodivScen ERA-Net COFUND program, and with the funding organizations Academy of Finland (329334, 326534 to PW, and 326533 to TM), Formas, and the National Science Foundation. The base colony of the voles (the selection experiment) was funded from National Science Centre (2016/23/B/NZ8/00888 to PK), and the Jagiellonian University (project DS/WBINOZ/INOS/757). ...Lisenssi
Samankaltainen aineisto
Näytetään aineistoja, joilla on samankaltainen nimeke tai asiasanat.
-
Intrinsic aerobic capacity governs the associations between gut microbiota composition and fat metabolism age-dependently in rat siblings
Pekkala, Satu; Lensu, Sanna; Nokia, Miriam; Vanhatalo, Sanja; Koch, Lauren G.; Britton, Steven L.; Kainulainen, Heikki (American Physiological Society, 2017)Host genetic factors affecting the gut microbiome play an important role in obesity, yet limited attention has been paid on the host genetic factors linked to physical fitness in modifying the microbiome. This study ... -
Is selection on higher aerobic capacity limited by food availability? : laboratory and field experiments in male bank vole (Myodes glareolus)
Hirvonen, Tanja (2021)Aineenvaihdunta määrittää, kuinka yksilön käytössä olevan energia kohdentuu eri toimintoihin, mikä tekee siitä merkittävän yksilön elinkiertoon vaikuttavan tekijän. Perusaineenvaihdunta, eli aineenvaihdunnan minimitaso, ... -
Voidaanko perinnöllisesti matala aerobinen kapasiteetti kumota hyvän aerobisen kapasiteetin omaavilta rotilta saadulla ulosteensiirteellä?
Venäläinen, Arttu (2021)Suolistomikrobiston koostumuksen on todettu vaikuttavan laajalti yksilön terveyteen ja olevan vaihtelevissa määrin periytyvä. Tämän pro gradu -tutkielman tarkoituksena oli selvittää ulosteensiirron vaikutuksia LCR- (low- ... -
Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity : The role of cardiorespiratory fitness
Cadenas‐Sanchez, Cristina; Medrano, María; Villanueva, Arantxa; Cabeza, Rafael; Idoate, Fernando; Osés, Maddi; Rodríguez‐Vigil, Beatriz; Álvarez de Eulate, Natalia; Alberdi Aldasoro, Nerea; Ortega, Francisco B.; Labayen, Idoia (Wiley, 2023)Objectives Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under-studied. Therefore, the aims of this study were: (i) ... -
Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; Cheng, Sulin; Wiklund, Petri (Springer, 2021)Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, ...
Ellei toisin mainittu, julkisesti saatavilla olevia JYX-metatietoja (poislukien tiivistelmät) saa vapaasti uudelleenkäyttää CC0-lisenssillä.