Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
Bradburn, S., McPhee, J., Bagley, L., Carroll, M., Slevin, M., Al-Shanti, N., Barnouin, Y., Hogrel, J.-Y., Pääsuke, M., Gapeyeva, H., Maier, A., Sipilä, S., Narici, M., Robinson, A., Mann, D., Payton, A., Pendleton, N., Butler-Browne, G., & Murgatroyd, C. (2018). Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. Neurobiology of Aging, 63, 54-64. https://doi.org/10.1016/j.neurobiolaging.2017.11.009
Published in
Neurobiology of AgingAuthors
Date
2018Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution license.
Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that altered methylation at one of these CpG sites further associated with working memory performance in 2 independent aging cohorts. Studying prefrontal cortex samples, we found higher CXCL10 protein levels in those with Alzheimer's disease, compared with aged controls. These findings support the association of peripheral inflammation, as demonstrated by CXCL10, in aging and cognitive decline. We reveal age-related epigenetic and genetic factors which contribute to the dysregulation of CXCL10.
...
Publisher
Elsevier Inc.ISSN Search the Publication Forum
0197-4580Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/27382467
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3067]
License
Except where otherwise noted, this item's license is described as © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution license.
Related items
Showing items with similar title or keywords.
-
Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer
Rajamäki, Kristiina; Taira, Aurora; Katainen, Riku; Välimäki, Niko; Kuosmanen, Anna; Plaketti, Roosa-Maria; Seppälä, Toni T.; Ahtiainen, Maarit; Wirta, Erkki-Ville; Vartiainen, Emilia; Sulo, Päivi; Ravantti, Janne; Lehtipuro, Suvi; Granberg, Kirsi J.; Nykter, Matti; Tanskanen, Tomas; Ristimäki, Ari; Koskensalo, Selja; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Taipale, Jussi; Mecklin, Jukka-Pekka; Aavikko, Mervi; Palin, Kimmo; Aaltonen, Lauri A. (Elsevier, 2021)Background and aims Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct pathway ... -
Active Gains in brain Using Exercise During Aging (AGUEDA) : protocol for a randomized controlled trial
Solis-Urra, Patricio; Molina-Hidalgo, Cristina; García-Rivero, Yolanda; Costa-Rodriguez, Claudia; Mora-Gonzalez, Jose; Fernandez-Gamez, Beatriz; Olvera-Rojas, Marcos; Coca-Pulido, Andrea; Toval, Angel; Bellón, Darío; Sclafani, Alessandro; Martín-Fuentes, Isabel; Triviño-Ibañez, Eva María; de Teresa, Carlos; Huang, Haiqing; Grove, George; Hillman, Charles H.; Kramer, Arthur F.; Catena, Andrés; Ortega, Francisco B.; Gómez-Río, Manuel; Erickson, Kirk I.; Esteban-Cornejo, Irene (Frontiers Media, 2023)Alzheimer’s disease is currently the leading cause of dementia and one of the most expensive, lethal and severe diseases worldwide. Age-related decline in executive function is widespread and plays a key role in subsequent ... -
Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging
Kankaanpää, Anna; Tolvanen, Asko; Bollepalli, Sailalitha; Leskinen, Tuija; Kujala, Urho M.; Kaprio, Jaakko; Ollikainen, Miina; Sillanpää, Elina (Lippincott Williams & Wilkins, 2021)Purpose: Greater leisure-time physical activity (LTPA) associates with healthier lives, but knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA methylation (DNAm) patterns capture age-related ... -
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
McCartney, Daniel L.; Min, Josine L.; Richmond, Rebecca C.; Lu, Ake T.; Sobczyk, Maria K.; Davies, Gail; Broer, Linda; Guo, Xiuqing; Jeong, Ayoung; Jung, Jeesun; Kasela, Silva; Katrinli, Seyma; Kuo, Pei-Lun; Matias-Garcia, Pamela R.; Mishra, Pashupati P.; Nygaard, Marianne; Palviainen, Teemu; Patki, Amit; Raffield, Laura M.; Ratliff, Scott M.; Richardson, Tom G.; Robinson, Oliver; Soerensen, Mette; Sun, Dianjianyi; Tsai, Pei-Chien; van der Zee, Matthijs D.; Walker, Rosie M.; Wang, Xiaochuan; Wang, Yunzhang; Xia, Rui; Xu, Zongli; Yao, Jie; Zhao, Wei; Correa, Adolfo; Boerwinkle, Eric; Dugué, Pierre-Antoine; Durda, Peter; Elliott, Hannah R.; Gieger, Christian; The Genetics of DNA Methylation Consortium; de Geus, Eco J. C.; Harris, Sarah E.; Hemani, Gibran; Imboden, Medea; Kähönen, Mika; Kardia, Sharon L. R.; Kresovich, Jacob K.; Li, Shengxu; Lunetta, Kathryn L.; Mangino, Massimo; Mason, Dan; McIntosh, Andrew M.; Mengel-From, Jonas; Moore, Ann Zenobia; Murabito, Joanne M.; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; Ollikainen, Miina; Pankow, James S.; Pedersen, Nancy L.; Peters, Annette; Polidoro, Silvia; Porteous, David J.; Raitakari, Olli; Rich, Stephen S.; Sandler, Dale P.; Sillanpää, Elina; Smith, Alicia K.; Southey, Melissa C.; Strauch, Konstantin; Tiwari, Hemant; Tanaka, Toshiko; Tillin, Therese; Uitterlinden, Andre G.; Van Den Berg, David J.; van Dongen, Jenny; Wilson, James G.; Wright, John; Yet, Idil; Arnett, Donna; Bandinelli, Stefania; Bell, Jordana T.; Binder, Alexandra M.; Boomsma, Dorret I.; Chen, Wei; Christensen, Kaare; Conneely, Karen N.; Elliott, Paul; Ferrucci, Luigi; Fornage, Myriam; Hägg, Sara; Hayward, Caroline; Irvin, Marguerite; Kaprio, Jaakko; Lawlor, Deborah A.; Lehtimäki, Terho; Lohoff, Falk W.; Milani, Lili; Milne, Roger L.; Probst-Hensch, Nicole; Reiner, Alex P.; Ritz, Beate; Rotter, Jerome I.; Smith, Jennifer A.; Taylor, Jack A.; van Meurs, Joyce B. J.; Vineis, Paolo; Waldenberger, Melanie; Deary, Ian J.; Relton, Caroline L.; Horvath, Steve; Marioni, Riccardo E. (Biomed Central, 2021)Background Biological aging estimators derived from DNA methylation data are heritable and correlate with morbidity and mortality. Consequently, identification of genetic and environmental contributors to the variation ... -
Blood and skeletal muscle ageing determined by epigenetic clocks and their associations with physical activity and functioning
Sillanpää, Elina; Heikkinen, Aino; Kankaanpää, Anna; Paavilainen, Aini; Kujala, Urho M.; Tammelin, Tuija H.; Kovanen, Vuokko; Sipilä, Sarianna; Pietiläinen, Kirsi H.; Kaprio, Jaakko; Ollikainen, Miina; Laakkonen, Eija K. (Biomed Central, 2021)The aim of this study was to investigate the correspondence of different biological ageing estimates (i.e. epigenetic age) in blood and muscle tissue and their associations with physical activity (PA), physical function ...