Näytä suppeat kuvailutiedot

dc.contributor.authorBradburn, Steven
dc.contributor.authorMcPhee, Jamie
dc.contributor.authorBagley, Liam
dc.contributor.authorCarroll, Michael
dc.contributor.authorSlevin, Mark
dc.contributor.authorAl-Shanti, Nasser
dc.contributor.authorBarnouin, Yoann
dc.contributor.authorHogrel, Jean-Yves
dc.contributor.authorPääsuke, Mati
dc.contributor.authorGapeyeva, Helena
dc.contributor.authorMaier, Andrea
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorNarici, Marco
dc.contributor.authorRobinson, Andrew
dc.contributor.authorMann, David
dc.contributor.authorPayton, Antony
dc.contributor.authorPendleton, Neil
dc.contributor.authorButler-Browne, Gillian
dc.contributor.authorMurgatroyd, Chris
dc.date.accessioned2017-12-19T12:09:47Z
dc.date.available2017-12-19T12:09:47Z
dc.date.issued2018
dc.identifier.citationBradburn, S., McPhee, J., Bagley, L., Carroll, M., Slevin, M., Al-Shanti, N., Barnouin, Y., Hogrel, J.-Y., Pääsuke, M., Gapeyeva, H., Maier, A., Sipilä, S., Narici, M., Robinson, A., Mann, D., Payton, A., Pendleton, N., Butler-Browne, G., & Murgatroyd, C. (2018). Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance. <i>Neurobiology of Aging</i>, <i>63</i>, 54-64. <a href="https://doi.org/10.1016/j.neurobiolaging.2017.11.009" target="_blank">https://doi.org/10.1016/j.neurobiolaging.2017.11.009</a>
dc.identifier.otherCONVID_27382467
dc.identifier.otherTUTKAID_75858
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/56436
dc.description.abstractChronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy young and old adults from the MyoAge cohort. Peripheral levels of C-X-C motif chemokine ligand 10 (CXCL10) was found to be higher in older adults, compared with young, and negatively associated with working memory performance. This coincided with an age-related reduction in blood DNA methylation at specific CpGs within the CXCL10 gene promoter. In vitro analysis supported the role of DNA methylation in regulating CXCL10 transcription. A polymorphism (rs56061981) that altered methylation at one of these CpG sites further associated with working memory performance in 2 independent aging cohorts. Studying prefrontal cortex samples, we found higher CXCL10 protein levels in those with Alzheimer's disease, compared with aged controls. These findings support the association of peripheral inflammation, as demonstrated by CXCL10, in aging and cognitive decline. We reveal age-related epigenetic and genetic factors which contribute to the dysregulation of CXCL10.
dc.language.isoeng
dc.publisherElsevier Inc.
dc.relation.ispartofseriesNeurobiology of Aging
dc.subject.othercognitive aging
dc.subject.otherAlzheimer’s disease
dc.subject.otherinflammaging
dc.subject.otherneurodegeneration
dc.titleDysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201712124624
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-12-12T07:15:25Z
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange54-64
dc.relation.issn0197-4580
dc.relation.numberinseries0
dc.relation.volume63
dc.type.versionpublishedVersion
dc.rights.copyright© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution license.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoAlzheimerin tauti
dc.subject.ysokognitiiviset taidot
dc.subject.ysoikääntyminen
dc.subject.ysoepigenetiikka
dc.subject.ysoDNA-metylaatio
jyx.subject.urihttp://www.yso.fi/onto/yso/p8412
jyx.subject.urihttp://www.yso.fi/onto/yso/p24920
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p24631
jyx.subject.urihttp://www.yso.fi/onto/yso/p38350
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.neurobiolaging.2017.11.009
dc.type.okmA1


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© 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution license.
Ellei muuten mainita, aineiston lisenssi on © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the Creative Commons Attribution license.