Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial
Cheng, S., Ge, J., Zhao, C., Le, S., Yang, Y., Ke, D., . . . Lu, D. (2017). Effect of aerobic exercise and diet on liver fat in pre-diabetic patients with non-alcoholic-fatty-liver-disease: A randomized controlled trial. Scientific Reports, 7, 15952. doi:10.1038/s41598-017-16159-x
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Scientific ReportsDate
2017Discipline
LiikuntalääketiedeCopyright
© the Authors, 2017. This article is licensed under a Creative Commons Attribution 4.0 International License.
The study aimed to assess whether aerobic exercise (AEx) training and a fbre-enriched diet can reduce
hepatic fat content (HFC) and increase glycaemic control in pre-diabetic patients with non-alcoholic
fatty liver disease (NAFLD). Six-hundred-and-three patients from seven clinics in Yangpu district,
Shanghai, China were recruited. Of them 115 individuals aged 50–65-year fulflled the inclusion criteria
(NAFLD with impaired fasting glucose or impaired glucose tolerance) and were randomly assigned into
exercise (AEx n=29), diet (Diet n=28), exercise plus diet (AED n=29), or no-intervention (NI n=29)
groups. Progressive supervised AEx training (60–75% VO2max intensity) was given 2-3 times/week in
30–60min/sessions, and the diet intervention was provided as lunch with 38% carbohydrate and diet
fbre of 12g/day for 8.6-month. HFC was assessed by 1H MRS. We found that HFC was signifcantly
reduced in the AEx (−24.4%), diet (−23.2%), and AED (−47.9%) groups by contrast to the 20.9%
increase in the NI group (p=0.001 for all) after intervention. However, only AED group signifcantly
decreased HbA1c (−4.4%, p=0.01) compared with the NI group (−0.6%). Aerobic exercise training
combined with fbre-enriched diet can reduce HFC more efectively than either exercise or increased
fbre-intake alone in pre-diabetic patients with NAFLD.
...


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