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dc.contributor.authorSillanpää, Elina
dc.contributor.authorSipilä, Sarianna
dc.contributor.authorTörmäkangas, Timo
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorRantanen, Taina
dc.date.accessioned2017-11-07T09:50:41Z
dc.date.available2017-11-17T22:45:12Z
dc.date.issued2017
dc.identifier.citationSillanpää, E., Sipilä, S., Törmäkangas, T., Kaprio, J., & Rantanen, T. (2017). Genetic and Environmental Effects on Telomere Length and Lung Function : A Twin Study. <i>Journals of Gerontology Series A: Biological Sciences and Medical Sciences</i>, <i>72</i>(11), 1561-1568. <a href="https://doi.org/10.1093/gerona/glw178" target="_blank">https://doi.org/10.1093/gerona/glw178</a>
dc.identifier.otherCONVID_26319896
dc.identifier.otherTUTKAID_71744
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/55776
dc.description.abstractBackground The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. Methods 386 monozygotic and dizygotic Finnish twin sisters (age 68.4±3.4 years) were included. Relative LTL was determined from peripheral blood DNA by qPCR. Lung function measures of FEV1, FVC, FEV1/FVC, and PEF were derived from spirometry. Genetic modeling was performed with MPlus statistical software. Results Univariate analysis revealed that in LTL, 62% (95% confidence interval 50–72) of the variance was explained by additive genetic and 38% (28–50) by unique environmental factors. For FEV1, FVC, and PEF, the corresponding estimates were 65%–67% for additive genetic and 33%–35% for unique environmental factors. Across the sample, the phenotypic correlation between LTL and FEV1 was modest (r = .104, p = .041). Bivariate correlated factors model revealed that the genetic correlation between LTL and FEV1 was .18 (−0.19 to 0.64) and environmental correlation was −.10 (−0.84 to 0.55). Conclusions Both LTL and lung function variables are moderately to highly genetically determined. The associations between LTL and the lung function variables were weak. However, the positive genetic correlation point estimate gave minor suggestions that, in a larger sample, genetic factors in common might play a role in the phenotypic correlation between LTL and FEV1. Future studies with larger samples are needed to confirm these preliminary findings.
dc.language.isoeng
dc.publisherOxford University Press; The Gerontological Society of America
dc.relation.ispartofseriesJournals of Gerontology Series A: Biological Sciences and Medical Sciences
dc.subject.othergenetic modeling
dc.titleGenetic and Environmental Effects on Telomere Length and Lung Function : A Twin Study
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201710304095
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-10-30T16:15:09Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange1561-1568
dc.relation.issn1079-5006
dc.relation.numberinseries11
dc.relation.volume72
dc.type.versionacceptedVersion
dc.rights.copyright© The Authors 2016. This is a final draft version of an article whose final and definitive form has been published by Oxford University Press on behalf of The Gerontological Society of America. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysospirometria
dc.subject.ysotelomeerit
jyx.subject.urihttp://www.yso.fi/onto/yso/p9036
jyx.subject.urihttp://www.yso.fi/onto/yso/p37745
dc.relation.doi10.1093/gerona/glw178


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