University of Jyväskylä | JYX Digital Repository

  • English  | Give feedback |
    • suomi
    • English
 
  • Login
JavaScript is disabled for your browser. Some features of this site may not work without it.
View Item 
  • JYX
  • Artikkelit
  • Liikuntatieteiden tiedekunta
  • View Item
JYX > Artikkelit > Liikuntatieteiden tiedekunta > View Item

Telomere length in circulating leukocytes is associated with lung function and disease

ThumbnailFinal Draft
View/Open
144.5Kb

Downloads:  
Show download detailsHide download details  
Albrecht, E., Sillanpää, E., Karrasch, S., Alves, A., Codd, V., Hovatta, I., . . . Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease. European Respiratory Journal, 43 (4), 983-992. doi:10.1183/09031936.00046213
Published in
European Respiratory Journal
Authors
Albrecht, Eva |
Sillanpää, Elina |
Karrasch, Stefan |
Alves, Alexessander Couto |
Codd, Veryan |
Hovatta, Iiris |
Buxton, Jessica L |
Nelson, Christopher P |
Broer, Linda |
Hägg, Sara |
Mangino, Massimo |
Willemsen, Gonneke |
Surakka, Ida |
Ferreira, Manuel AR |
Amin, Najaf |
Oostra, Ben A |
Bäckmand, Heli M |
Peltonen, Markku |
Sarna, Seppo |
Rantanen, Taina |
Sipilä, Sarianna |
Korhonen, Tellervo |
Madden, Pamela AF |
Gieger, Christian |
Jörres, Rudolf A |
Heinrich, Joachim |
Behr, Jürgen |
Huber, Rudolf M |
Peters, Annette |
Strauch, Konstantin |
Wichmann, H.Erich |
Waldenberger, Melanie |
Blakemore, Alexandra IF |
Geus, Eco JC de |
Nyholt, Dale R |
Henders, Anjali K |
Piirilä, Päivi L |
Rissanen, Aila |
Magnusson, Patrik KE |
Viñuela, Ana |
Pietiläinen, Kirsi H |
Martin, Nicholas G |
Pedersen, Nancy L |
Boomsma, Dorret I |
Spector, Tim D |
Duijn, Cornelia M van |
Kaprio, Jaakko |
Samani, Nilesh J |
Jarvelin, Marjo-Riitta |
Schulz, Holger
Date
2014
Discipline
Gerontologia ja kansanterveys
Copyright
© European Respiratory Society 2014. This is an author's final draft version of an article whose final and definitive form has been published by ERS. Published in this repository with the kind permission of the publisher.

 
Several clinical studies suggest the involvement of premature aging processes in COPD. Using an epidemiological approach we studied whether accelerated aging indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the inter-individual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15,846 controls defined according to GLI criteria (or 1,189 COPD cases according to GOLD), 2,834 asthma cases with 28,195 controls, and spirometric parameters (FEV1, FVC and FEV1/FVC) of 12,595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex, and smoking status.We observed negative associations between telomere length and COPD being stronger for COPD defined by GLI than GOLD (β=-0.0982, p=0.001 vs. β=-0.0676, p=0.018) as well as asthma (β=-0.0452, p=0.024), with stronger effects in women compared to men. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07x10-7), FVC (p=2.07x10-5), and their ratio FEV1/FVC (p=5.27x10-3). The effect was somewhat weaker in apparently healthy subjects compared to COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma and that lung function may reflect biological aging primarily due to intrinsic processes which are likely to be aggravated in lung diseases. ...
Publisher
European Respiratory Society
ISSN Search the Publication Forum
1399-3003
Keywords
biological age premature aging COPD asthma spirometry biologinen ikä telomeeri spirometria keuhkoahtaumatauti astma ennenaikainen vanheneminen
DOI
10.1183/09031936.00046213
URI

http://urn.fi/URN:NBN:fi:jyu-201412313592

Metadata
Show full item record
Collections
  • Liikuntatieteiden tiedekunta [1547]
  • Browse materials
  • Browse materials
  • Articles
  • Conferences and seminars
  • Electronic books
  • Historical maps
  • Journals
  • Tunes and musical notes
  • Photographs
  • Presentations and posters
  • Publication series
  • Research reports
  • Research data
  • Study materials
  • Theses

Browse

All of JYXCollection listBy Issue DateAuthorsSubjectsPublished inDepartmentDiscipline

My Account

Login

Statistics

View Usage Statistics
  • How to publish in JYX?
  • Self-archiving
  • Publish Your Thesis Online
  • Publishing Your Dissertation
  • Publication services

Open Science at the JYU
 
Data Protection Description

Accessibility Statement
Open Science Centre