Telomere length in circulating leukocytes is associated with lung function and disease
Albrecht, E., Sillanpää, E., Karrasch, S., Alves, A. C., Codd, V., Hovatta, I., Buxton, J. L., Nelson, C. P., Broer, L., Hägg, S., Mangino, M., Willemsen, G., Surakka, I., Ferreira, M. A., Amin, N., Oostra, B. A., Bäckmand, H. M., Peltonen, M., Sarna, S., . . . Schulz, H. (2014). Telomere length in circulating leukocytes is associated with lung function and disease. European Respiratory Journal, 43(4), 983-992. https://doi.org/10.1183/09031936.00046213
Published inEuropean Respiratory Journal
© European Respiratory Society 2014. This is an author's final draft version of an article whose final and definitive form has been published by ERS. Published in this repository with the kind permission of the publisher.
Several clinical studies suggest the involvement of premature aging processes in COPD. Using an epidemiological approach we studied whether accelerated aging indicated by telomere length, a marker of biological age, is associated with COPD and asthma, and whether intrinsic age-related processes contribute to the inter-individual variability of lung function. Our meta-analysis of 14 studies included 934 COPD cases with 15,846 controls defined according to GLI criteria (or 1,189 COPD cases according to GOLD), 2,834 asthma cases with 28,195 controls, and spirometric parameters (FEV1, FVC and FEV1/FVC) of 12,595 individuals. Associations with telomere length were tested by linear regression, adjusting for age, sex, and smoking status.We observed negative associations between telomere length and COPD being stronger for COPD defined by GLI than GOLD (β=-0.0982, p=0.001 vs. β=-0.0676, p=0.018) as well as asthma (β=-0.0452, p=0.024), with stronger effects in women compared to men. The investigation of spirometric indices showed positive associations between telomere length and FEV1 (p=1.07x10-7), FVC (p=2.07x10-5), and their ratio FEV1/FVC (p=5.27x10-3). The effect was somewhat weaker in apparently healthy subjects compared to COPD or asthma patients. Our results provide indirect evidence for the hypothesis that cellular senescence may contribute to the pathogenesis of COPD and asthma and that lung function may reflect biological aging primarily due to intrinsic processes which are likely to be aggravated in lung diseases. ...
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Genome-Wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length Li, Chen; Stoma, Svetlana; Lotta, Luca A.; Warner, Sophie; Albrecht, Eva; Allione, Alessandra; Arp, Pascal P.; Broer, Linda; Buxton, Jessica L.; Da Silva Couto Alves, Alexessander; Deelen, Joris; Fedko, Iryna O.; Gordon, Scott D.; Jiang, Tao; Karlsson, Robert; Kerrison, Nicola; Loe, Taylor K.; Mangino, Massimo; Milaneschi, Yuri; Miraglio, Benjamin; Pervjakova, Natalia; Russo, Alessia; Surakka, Ida; van der Spek, Ashley; Verhoeven, Josine E.; Amin, Najaf; Beekman, Marian; Blakemore, Alexandra I.; Canzian, Federico; Hamby, Stephen E.; Hottenga, Jouke-Jan; Jones, Peter D.; Jousilahti, Pekka; Mägi, Reedik; Medland, Sarah E.; Montgomery, Grant W.; Nyholt, Dale R.; Perola, Markus; Pietiläinen, Kirsi H.; Salomaa, Veikko; Sillanpää, Elina; Suchiman, H. Eka; van Heemst, Diana; Willemsen, Gonneke; Agudo, Antonio; Boeing, Heiner; Boomsma, Dorret I.; Chirlaque, Maria-Dolores; Fagherazzi, Guy; Ferrari, Pietro; Franks, Paul; Gieger, Christian; Eriksson, Johan Gunnar; Gunter, Marc; Hägg, Sara; Hovatta, Iiris; Imaz, Liher; Kaprio, Jaakko; Kaaks, Rudolf; Key, Timothy; Krogh, Vittorio; Martin, Nicholas G.; Melander, Olle; Metspalu, Andres; Moreno, Concha; Onland-Moret, N. Charlotte; Nilsson, Peter; Ong, Ken K.; Overvad, Kim; Palli, Domenico; Panico, Salvatore; Pedersen, Nancy L.; Penninx, Brenda W. J. H.; Quirós, J. Ramón; Jarvelin, Marjo Riitta; Rodríguez-Barranco, Miguel; Scott, Robert A.; Severi, Gianluca; Slagboom, P. Eline; Spector, Tim D.; Tjonneland, Anne; Trichopoulou, Antonia; Tumino, Rosario; Uitterlinden, André G.; van der Schouw, Yvonne T.; van Duijn, Cornelia M.; Weiderpass, Elisabete; Denchi, Eros Lazzerini; Matullo, Giuseppe; Butterworth, Adam S.; Danesh, John; Samani, Nilesh J.; Wareham, Nicholas J.; Nelson, Christopher P.; Langenberg, Claudia; Codd, Veryan (Cell Press, 2020)Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed association results across large-scale ...
Sillanpää, Elina; Sipilä, Sarianna; Törmäkangas, Timo; Kaprio, Jaakko; Rantanen, Taina (Oxford University Press; The Gerontological Society of America, 2017)Background The purpose of the study was to estimate the heritability of leukocyte telomere length (LTL) and lung function and to examine whether LTL and lung function share genetic or environmental effects in common. M ...
Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy Sillanpää, Elina; Niskala, Paula; Laakkonen, Eija; Ponsot, Elodie; Alén, Markku; Kaprio, Jaakko; Kadi, Fawzi; Kovanen, Vuokko; Sipilä, Sarianna (Cambridge University Press; International Society for Twin Studies, 2017)Estrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere ...
Does Longer Leukocyte Telomere Length and Higher Physical Fitness Protect Master Athletes From Consequences of Coronavirus (SARS-CoV-2) Infection? Simões, Herbert Gustavo; Rosa, Thiago Santos; Sousa, Caio Victor; da Silva Aguiar, Samuel; Motta-Santos, Daisy; Degens, Hans; Korhonen, Marko T.; Grubert Campbell, Carmen Silvia (Frontiers Media, 2020)
Haapanen, Markus J.; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria A.; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; von Bonsdorff, Mikaela (Elsevier Inc., 2018)Objectives: Telomere length is associated with aging-related pathologies. Although the association between telomere length and frailty has been studied previously, only a few studies assessing longitudinal changes in ...