Effects of the cancer and muscle growth on lipid metabolism in adipose tissue and skeletal muscle
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Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue
Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; Cheng, Sulin; Wiklund, Petri (Springer, 2021)Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, ... -
Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver
Hentilä, Jaakko; Nissinen, Tuuli; Korkmaz, Ayhan; Lensu, Sanna; Silvennoinen, Mika; Pasternack, Arja; Ritvos, Olli; Atalay, Mustafa; Hulmi, Juha (Frontiers Research Foundation, 2019)Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein ... -
The impact of preoperative treatments on the immune environment of rectal cancer
Wirta, Erkki‐Ville; Elomaa, Hanna; Ahtiainen, Maarit; Hyöty, Marja; Seppälä, Toni T.; Kuopio, Teijo; Böhm, Jan; Mecklin, Jukka‐Pekka; Väyrynen, Juha P. (Wiley-Blackwell, 2024)To improve local disease control, the use of preoperative radiotherapy either alone or combined with chemotherapy has become standard practice in rectal cancer, but it is unclear how these treatments modify the antitumoral ... -
Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
Elomaa, Hanna; Ahtiainen, Maarit; Väyrynen, Sara A.; Ogino, Shuji; Nowak, Jonathan A.; Friman, Marjukka; Helminen, Olli; Wirta, Erkki-Ville; Seppälä, Toni T.; Böhm, Jan; Mäkinen, Markus J.; Mecklin, Jukka-Pekka; Kuopio, Teijo; Väyrynen, Juha P. (Nature Publishing Group, 2022)BACKGROUND: Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic ... -
Spatially resolved multimarker evaluation of CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint expression and macrophage polarisation in colorectal cancer
Elomaa, Hanna; Ahtiainen, Maarit; Väyrynen, Sara A.; Ogino, Shuji; Nowak, Jonathan A.; Lau, Mai Chan; Helminen, Olli; Wirta, Erkki-Ville; Seppälä, Toni T.; Böhm, Jan; Mecklin, Jukka-Pekka; Kuopio, Teijo; Väyrynen, Juha P. (Nature Publishing Group, 2023)Background The CD274 (PD-L1)/PDCD1 (PD-1) immune checkpoint interaction may promote cancer progression, but the expression patterns and prognostic significance of PD-L1 and PD-1 in the colorectal cancer microenvironment ...