Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer
Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Ogino, S., Nowak, J. A., Friman, M., Helminen, O., Wirta, E.-V., Seppälä, T. T., Böhm, J., Mäkinen, M. J., Mecklin, J.-P., Kuopio, T., & Väyrynen, J. P. (2022). Prognostic significance of spatial and density analysis of T lymphocytes in colorectal cancer. British Journal of Cancer, 127(3), 514-523. https://doi.org/10.1038/s41416-022-01822-6
Julkaistu sarjassa
British Journal of CancerTekijät
Päivämäärä
2022Tekijänoikeudet
© 2022 the Authors
BACKGROUND: Although high T cell density is a strong favourable prognostic factor in colorectal cancer, the significance of the spatial distribution of T cells is incompletely understood. We aimed to evaluate the prognostic significance of tumour cell-T cell colocalisation and T cell densities.
METHODS: We analysed CD3 and CD8 immunohistochemistry in a study cohort of 983 colorectal cancer patients and a validation cohort (N = 246). Individual immune and tumour cells were identified to calculate T cell densities (to derive T cell density score) and G-cross function values, estimating the likelihood of tumour cells being co-located with T cells within 20 µm radius (to derive T cell proximity score).
RESULTS: High T cell proximity score associated with longer cancer-specific survival in both the study cohort [adjusted HR for high (vs. low) 0.33, 95% CI 0.20–0.52, Ptrend < 0.0001] and the validation cohort [adjusted HR for high (vs. low) 0.15, 95% CI 0.05–0.45, Ptrend < 0.0001] and its prognostic value was independent of T cell density score.
CONCLUSIONS: The spatial point pattern analysis of tumour cell-T cell co-localisation could provide detailed information on colorectal cancer prognosis, supporting the value of spatial measurement of T cell infiltrates as a novel, robust tumour-immune biomarker.
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Julkaisija
Nature Publishing GroupISSN Hae Julkaisufoorumista
0007-0920Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/118886155
Metadata
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Lisätietoja rahoituksesta
This study was funded by Cancer Foundation Finland (59-5619 to JPV). SO’s effort was supported in part by a U.S. National Institutes of Health grant (R35 CA197735).Lisenssi
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