The impact of preoperative treatments on the immune environment of rectal cancer
Wirta, E., Elomaa, H., Ahtiainen, M., Hyöty, M., Seppälä, T. T., Kuopio, T., Böhm, J., Mecklin, J., & Väyrynen, J. P. (2024). The impact of preoperative treatments on the immune environment of rectal cancer. Apmis, Early View. https://doi.org/10.1111/apm.13467
Published in
ApmisAuthors
Date
2024Copyright
© 2024 The Author(s). APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
To improve local disease control, the use of preoperative radiotherapy either alone or combined with chemotherapy has become standard practice in rectal cancer, but it is unclear how these treatments modify the antitumoral immune response. We aimed to evaluate tumor histopathologic features and the prognostic effect of host immune response in rectal cancer with variable treatment modalities. Ninety-five rectal cancers with short-course radiotherapy (SRT), 97 with long-course chemoradiotherapy (CRT), and 154 without preoperative treatments, were evaluated for histopathologic features including Crohn's-like reaction (CLR). CD3+ and CD8+ immunohistochemistry and tumor cells were analyzed from tumor tissue microarray samples to calculate T-cell densities and G-cross function values to estimate cancer cell–T-cell co-localization (proximity score). We found that lymphocyte densities were diminished after SRT, but CLR was scarcer after CRT. Proximity score and CLR density were prognostic for survival in cancer without preoperative treatments and could be combined into an enhanced prognostic score (immune grade). In the irradiated tumors, CLR density remained prognostic while the impact of T-cell infiltration was insufficient alone. In multivariable analysis, the immune grade proved to be an independent prognostic factor for survival. In conclusion, the immune contexture of rectal cancer harbors prognostic significance even after preoperative radiotherapy.
...
Publisher
Wiley-BlackwellISSN Search the Publication Forum
0903-4641Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/242698227
Metadata
Show full item recordCollections
Additional information about funding
E-VW was supported by the Finnish Medical Foundation, the Mary and Georg C. Ehrnrooth Foundation, Cancer Foundation Finland, and the Ida Montin Foundation. TTS was supported by Cancer Foundation Finland, the Jane and Aatos Erkko Foundation, the Emil Aaltonen Foundation, the Sigrid Juselius Foundation, the Relander Foun-dation, and iCAN Flagship of the Academy of Fin-land. J-PM was supported by Cancer Foundation Finland, the Jane and Aatos Erkko Foundation, and Finnish State Research Funding. JPV was sup-ported by Cancer Foundation Finland. ...License
Related items
Showing items with similar title or keywords.
-
The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
Jääskeläinen, Minna M.; Tiainen, Satu; Siiskonen, Hanna; Ahtiainen, Maarit; Kuopio, Teijo; Rönkä, Aino; Kettunen, Tiia; Hämäläinen, Kirsi; Rilla, Kirsi; Harvima, Ilkka; Mannermaa, Arto; Auvinen, Päivi (Springer, 2023)Purpose In HER2-positive (HER2 +) breast cancer, tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may influence the efficacy of the HER2-antibody trastuzumab and the patient’s outcome. In this ... -
Immune Contexture of MMR-Proficient Primary Colorectal Cancer and Matched Liver and Lung Metastases
Ahtiainen, Maarit; Elomaa, Hanna; Väyrynen, Juha P.; Wirta, Erkki-Ville; Kuopio, Teijo; Helminen, Olli; Seppälä, Toni T.; Kellokumpu, Ilmo; Mecklin, Jukka-Pekka (MDPI AG, 2021)Purpose: To evaluate immune cell infiltration, the programmed death-1/programmed death ligand-1 (PD-1/PD-L1) expression and their prognostic value in a series of mismatch proficient (pMMR) CRC with matched liver and lung ... -
CD3+ and CD8+ T-Cell-Based Immune Cell Score and PD-(L)1 Expression in Pulmonary Metastases of Microsatellite Stable Colorectal Cancer
Karjula, Topias; Elomaa, Hanna; Niskakangas, Anne; Mustonen, Olli; Puro, Iiris; Kuopio, Teijo; Ahtiainen, Maarit; Mecklin, Jukka-Pekka; Seppälä, Toni, T.; Wirta, Erkki-Ville; Sihvo, Eero; Väyrynen, Juha, P.; Yannopoulos, Fredrik; Helminen, Olli (MDPI AG, 2023)Simple Summary The lung is the second most common site of metastases in colorectal cancer (CRC). The aim of our study was to evaluate the prognostic value of CD3+ and CD8+ T-cell density based immune cell score (ICS) ... -
Prognostic Value of Immune Environment Analysis in Small Bowel Adenocarcinomas with Verified Mutational Landscape and Predisposing Conditions
Wirta, Erkki-Ville; Szeto, Säde; Hänninen, Ulrika; Ahtiainen, Maarit; Böhm, Jan; Mecklin, Jukka-Pekka; Aaltonen, Lauri A.; Seppälä, Toni T. (MDPI, 2020)Background: Small bowel adenocarcinoma (SBA) is a rare yet insidious cancer with poor survival. The abundance of tumour-infiltrating lymphocytes is associated with improved survival, but the role of the programmed ... -
Impact of Primary Tumor Location on Demographics, Resectability, Outcomes, and Quality of Life in Finnish Metastatic Colorectal Cancer Patients (Subgroup Analysis of the RAXO Study)
Aho, Sonja; Osterlund, Emerik; Ristimäki, Ari; Nieminen, Lasse; Sundström, Jari; Mäkinen, Markus J.; Kuopio, Teijo; Kytölä, Soili; Ålgars, Annika; Ristamäki, Raija; Heervä, Eetu; Kallio, Raija; Halonen, Päivi; Soveri, Leena-Maija; Nordin, Arno; Uutela, Aki; Salminen, Tapio; Stedt, Hanna; Lamminmäki, Annamarja; Muhonen, Timo; Kononen, Juha; Glimelius, Bengt; Isoniemi, Helena; Lehto, Juho T.; Lehtomäki, Kaisa; Osterlund, Pia (MDPI AG, 2024)The primary tumor location (PTL) is associated with the phenotype, metastatic sites, mutations, and outcomes of metastatic colorectal cancer (mCRC) patients, but this has mostly been studied according to sidedness (right ...