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• Interactive effects of aging and aerobic capacity on energy metabolism–related metabolites of serum, skeletal muscle, and white adipose tissue 

  Zhuang, Haihui; Karvinen, Sira; Törmäkangas, Timo; Zhang, Xiaobo; Ojanen, Xiaowei; Velagapudi, Vidya; Alen, Markku; Britton, Steven L.; Koch, Lauren G.; Kainulainen, Heikki; Cheng, Sulin; Wiklund, Petri (Springer, 2021)

  Aerobic capacity is a strong predictor of longevity. With aging, aerobic capacity decreases concomitantly with changes in whole body metabolism leading to increased disease risk. To address the role of aerobic capacity, ...

• Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver 

  Hentilä, Jaakko; Nissinen, Tuuli; Korkmaz, Ayhan; Lensu, Sanna; Silvennoinen, Mika; Pasternack, Arja; Ritvos, Olli; Atalay, Mustafa; Hulmi, Juha (Frontiers Research Foundation, 2019)

  Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein ...

• MIHIC: a multiplex IHC histopathological image classification dataset for lung cancer immune microenvironment quantification 

  Wang, Ranran; Qiu, Yusong; Wang, Tong; Wang, Mingkang; Jin, Shan; Cong, Fengyu; Zhang, Yong; Xu, Hongming (Frontiers Media, 2024)

  Background: Immunohistochemistry (IHC) is a widely used laboratory technique for cancer diagnosis, which selectively binds specific antibodies to target proteins in tissue samples and then makes the bound proteins visible ...

• Assessment of targeted therapy opportunities in sinonasal cancers using patient-derived functional tumor models 

  Lehtinen, Noora; Suhonen, Janne; Rice, Kiesha; Välimäki, Eetu; Toriseva, Mervi; Routila, Johannes; Halme, Perttu; Rahi, Melissa; Irjala, Heikki; Leivo, Ilmo; Kallajoki, Markku; Nees, Matthias; Kuopio, Teijo; Ventelä, Sami; Rantala, Juha K. (Neoplasia Press, 2024)

  Malignant tumors derived from the epithelium lining the nasal cavity region are termed sinonasal cancers, a highly heterogeneous group of rare tumors accounting for 3 – 5 % of all head and neck cancers. Progress with ...

• Immunological and prognostic significance of tumour necrosis in colorectal cancer 

  Kastinen, Meeri; Sirniö, Päivi; Elomaa, Hanna; Ahtiainen, Maarit; Väyrynen, Sara A.; Herzig, Karl-Heinz; Meriläinen, Sanna; Aro, Raila; Häivälä, Reetta; Rautio, Tero; Saarnio, Juha; Wirta, Erkki-Ville; Helminen, Olli; Seppälä, Toni T.; Kuopio, Teijo; Böhm, Jan; Tuomisto, Anne; Mecklin, Jukka-Pekka; Mäkinen, Markus J.; Väyrynen, Juha P. (Nature Publishing Group, 2023)

  Background Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations ...