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dc.contributor.authorSillanpää, Elina
dc.contributor.authorNiskala, Paula
dc.contributor.authorLaakkonen, Eija
dc.contributor.authorPonsot, Elodie
dc.contributor.authorAlén, Markku
dc.contributor.authorKaprio, Jaakko
dc.contributor.authorKadi, Fawzi
dc.contributor.authorKovanen, Vuokko
dc.contributor.authorSipilä, Sarianna
dc.date.accessioned2017-05-10T09:59:11Z
dc.date.available2017-08-14T21:45:09Z
dc.date.issued2017
dc.identifier.citationSillanpää, E., Niskala, P., Laakkonen, E., Ponsot, E., Alén, M., Kaprio, J., Kadi, F., Kovanen, V., & Sipilä, S. (2017). Leukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy. <i>Twin Research and Human Genetics</i>, <i>20</i>(2), 119-131. <a href="https://doi.org/10.1017/thg.2017.1" target="_blank">https://doi.org/10.1017/thg.2017.1</a>
dc.identifier.otherCONVID_26564626
dc.identifier.otherTUTKAID_73070
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/53868
dc.description.abstractEstrogen-based hormone replacement therapy (HRT) may be associated with deceleration of cellular aging. We investigated whether long-term HRT has effects on leukocyte (LTL) or mean and minimum skeletal muscle telomere length (SMTL) in a design that controls for genotype and childhood environment. Associations between telomeres, body composition, and physical performance were also examined. Eleven monozygotic twin pairs (age 57.6 ± 1.8 years) discordant for HRT were studied. Mean duration of HRT use was 7.3 ± 3.7 years in the user sister, while their co-twins had never used HRT. LTL was measured by qPCR and SMTLs by southern blot. Body and muscle composition were estimated by bioimpedance and computed tomography, respectively. Physical performance was measured by jumping height and grip strength. HRT users and non-users did not differ in LTL or mean or minimum SMTL. Within-pair correlations were high in LTL (r = 0.69, p = .020) and in mean (r = 0.74, p = .014) and minimum SMTL (r = 0.88, p = .001). Body composition and performance were better in users than non-users. In analyses of individuals, LTL was associated with BMI (r 2 = 0.30, p = .030), percentage total body (r 2 = 0.43, p = .014), and thigh (r 2 = 0.55, p = .004) fat, while minimum SMTL was associated with fat-free mass (r 2 = 0.27, p = .020) and thigh muscle area (r 2 = 0.42, p = .016). We found no associations between HRT use and telomere length. Longer LTLs were associated with lower total and regional fat, while longer minimum SMTLs were associated with higher fat-free mass and greater thigh muscle area. This suggests that telomeres measured from different tissues may have different associations with measures of body composition.
dc.language.isoeng
dc.publisherCambridge University Press; International Society for Twin Studies
dc.relation.ispartofseriesTwin Research and Human Genetics
dc.subject.otherestrogen
dc.subject.otherpercentage of fat
dc.subject.otherfat-free mass
dc.subject.otherbioimpedance
dc.subject.othertwin design
dc.subject.otherpost-menopausal
dc.titleLeukocyte and Skeletal Muscle Telomere Length and Body Composition in Monozygotic Twin Pairs Discordant for Long-term Hormone Replacement Therapy
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-201705082234
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.date.updated2017-05-08T12:15:29Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerange119-131
dc.relation.issn1832-4274
dc.relation.numberinseries2
dc.relation.volume20
dc.type.versionacceptedVersion
dc.rights.copyright© The Author(s) 2017. This is a final draft version of an article whose final and definitive form has been published by Cambridge University Press. Published in this repository with the kind permission of the publisher.
dc.rights.accesslevelopenAccessfi
dc.subject.ysotelomeerit
dc.subject.ysotietokonetomografia
jyx.subject.urihttp://www.yso.fi/onto/yso/p37745
jyx.subject.urihttp://www.yso.fi/onto/yso/p20535
dc.relation.doi10.1017/thg.2017.1


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