Association between osteocalcin and cognitive performance in healthy older adults
Bradburn, S., McPhee, J. S., Bagley, L., Sipilä, S., Stenroth, L., Narici, M. V., Pääsuke, M., Gapeyeva, H., Osborne, G., Sassano, L., Meskers, C. G. M., Maier, A. B., Hogrel, J.-Y., Barnouin, Y., Butler-Browne, G., & Murgatroyd, C. (2016). Association between osteocalcin and cognitive performance in healthy older adults. Age and Ageing, 45(6), 844-849. https://doi.org/10.1093/ageing/afw137
Published in
Age and AgeingAuthors
Date
2016Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© The Authors 2016. Published by Oxford University Press on behalf of the British Geriatrics Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution
Non-Commercial License.
Introduction: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship
between bone composition and plasma markers of bone remodelling with measures of cognitive performance in
healthy adults.
Methods: this cross-sectional study included 225 old (52% women, mean age: 74.4 ± 3.3 years) and 134 young (52% women,
mean age: 23.4 ± 2.7 years) adult participants from the MyoAge project. Whole body bone mineral density was measured by dualenergy
X-ray absorptiometry. Blood analyses included a panel of bone-related peptides (dickkopf-1, osteoprotegerin, osteocalcin
(OC), osteopontin, sclerostin, parathyroid hormone and fibroblast growth factor 23), as well as serum calcium and 25-hydroxy
vitamin D assays. A selection of cognitive domains (working memory capacity, episodic memory, executive functioning and
global cognition) was assessed with a standardised neuropsychological test battery.
Results: adjusting for covariates and multiple testing revealed that plasma OC levels were positively associated with measures
of executive functioning (β = 0.444, P < 0.001) and global cognition (β = 0.381, P = 0.001) in the older women.
Discussion: these correlative results demonstrate a positive association between OC, a factor known to regulate bone
remodelling, with cognitive performance in older non-demented women. Further work should address possible mechanistic
interpretations in humans.
...
Publisher
Oxford University Press; British Geriatrics SocietyISSN Search the Publication Forum
0002-0729Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/26179050
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3141]
License
Except where otherwise noted, this item's license is described as © The Authors 2016. Published by Oxford University Press on behalf of the British Geriatrics Society.
This is an Open Access article distributed under the terms of the Creative Commons Attribution
Non-Commercial License.
Related items
Showing items with similar title or keywords.
-
Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
Bezuch, Natalia Ewa; Bradburn, Steven; Sipilä, Sarianna; Pääsuke, Mati; Gapeyeva, Helena; Maier, Andrea B.; Hogrel, Jean-Yves; Barnouin, Yoann; Butler-Browne, Gillian; Narici, Marco; McPhee, Jamie; Murgatroyd, Chris (Elsevier BV, 2019)With increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin ... -
Relationship between cognitive performance and mobility over the life course
Poranen-Clark, Taina (Jyväskylän yliopisto, 2018) -
Ageing-related changes in cognitive functions and their associations with event-related potentials and physical fitness in healthy older adults
Mannila, Heikki; Vainio, Juhani (2019)Ageing manifests at least on the levels of structural degradation of the brain, as well as a slight cognitive decline even in healthy older adults. It is widely recognized that better physical fitness helps preserve cognitive ... -
Cognitive performance and its associations with physical fitness and demographic and socio-economic variables in healthy aging
Vesikukka, Miia (2016)TIIVISTELMÄ Kognitiivinen suoriutuminen ja sen yhteydet fyysiseen kuntoon ja demografisiin ja sosioekonomisiin taustatekijöihin terveesti ikääntyvillä naisilla Tämä pro gradu –tutkielma tarkasteli terveen ikääntymisen ... -
Dysregulation of C-X-C motif ligand 10 during aging and association with cognitive performance
Bradburn, Steven; McPhee, Jamie; Bagley, Liam; Carroll, Michael; Slevin, Mark; Al-Shanti, Nasser; Barnouin, Yoann; Hogrel, Jean-Yves; Pääsuke, Mati; Gapeyeva, Helena; Maier, Andrea; Sipilä, Sarianna; Narici, Marco; Robinson, Andrew; Mann, David; Payton, Antony; Pendleton, Neil; Butler-Browne, Gillian; Murgatroyd, Chris (Elsevier Inc., 2018)Chronic low-grade inflammation during aging (inflammaging) is associated with cognitive decline and neurodegeneration; however, the mechanisms underlying inflammaging are unclear. We studied a population (n = 361) of healthy ...