Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults
Bezuch, N. E., Bradburn, S., Sipilä, S., Pääsuke, M., Gapeyeva, H., Maier, A. B., Hogrel, J.-Y., Barnouin, Y., Butler-Browne, G., Narici, M., McPhee, J., & Murgatroyd, C. (2019). Association of interleukin-6 rs1800796 polymorphism with reduced cognitive performance in healthy older adults. Meta Gene, 19, 51-55. https://doi.org/10.1016/j.mgene.2018.10.007
Published in
Meta GeneAuthors
Date
2019Discipline
Gerontologia ja kansanterveysGerontologian tutkimuskeskusHyvinvoinnin tutkimuksen yhteisöGerontology and Public HealthGerontology Research CenterSchool of WellbeingCopyright
© 2018 Elsevier B.V.
With increasing life expectancy, age-associated cognitive impairment is an escalating problem worldwide. Inflammation is one of the features that characterises cognitive decline and can stimulate neurodegeneration. Interleukin 6 (IL-6) is a cytokine frequently associated with a pro-inflammatory phenotype and increased levels have been associated with the pathogenesis of dementia. The rs1800796 polymorphism in the promoter region of IL-6 gene was previously shown to influence IL-6 expression and therefore we hypothesised this gene polymorphism would be associated with IL-6 plasma levels and cognitive performance of older adults.
The present study investigated the association of the rs1800796 polymorphism on plasma IL-6 levels and cognition in healthy older adults (n = 207, 74.6 ± 3.4 years, 51% female) that participated in a Pan-European project (MyoAge). The participants were assessed for working memory capacity, executive functioning, episodic memory and global cognition using the Cambridge Neuropsychological Test Automated Battery CANTAB. Fasting plasma IL-6 levels were measured by ELISA and genotyping was performed using the KASP assay.
Results showed that the rs1800796 polymorphism was in Hardy-Weinberg equilibrium (P = .16) with the minor allele (C) showing a frequency of 6.3%. There were no differences in plasma IL-6 concentrations between the GG-homozygotes and C-allele carriers (P = .22). The C-allele carriers performed worse on a measure of executive functioning (P = .035) and had lower global cognitive scores (P = .045), compared to GG-homozygotes. These differences remained significant after accounting for age, sex and prior cognitive abilities (P < .05 for both). There were no differences in measures of memory (episodic and working) between the genotypes group.
These findings suggest that the rs1800796 variant may be detrimental for executive functioning, but not memory, in healthy older adults.
...
Publisher
Elsevier BVISSN Search the Publication Forum
2214-5400Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/28696183
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3151]
License
Related items
Showing items with similar title or keywords.
-
Effects of a 6-month dual-task, power-based exercise program on cognitive function, neurological and inflammatory markers in older adults : secondary analysis of a cluster randomised controlled trial
Tait, Jamie L.; Duckham, Rachel L.; Rantalainen, Timo; Milte, Catherine M.; Main, Luana C.; Nowson, Caryl A.; Sanders, Kerrie M.; Taaffe, Dennis R.; Hill, Keith D.; Abbott, Gavin; Daly, Robin M. (Springer, 2024)Functional power-based exercise training can improve physical performance in older adults and cognitive training can improve measures of cognition, but their combined effects on cognition and related risk factors (neurological ... -
Twin studies on the association of physical activity with cognitive and cerebral outcomes
Iso-Markku, Paula; Waller, Katja; Hautasaari, Pekka; Kaprio, Jaakko; Kujala, Urho M.; Tarkka, Ina M. (Elsevier, 2020)Regular physical activity (PA) offers positive effects on the human body. However, the effects of PA on cognition and in the brain are less clear. In this paper, we narratively review the relationship of PA with cognition ... -
Rats bred for low intrinsic aerobic exercise capacity link obesity with brain inflammation and reduced structural plasticity of the hippocampus
Mäkinen, Elina; Lensu, Sanna; Honkanen, Markus; Laitinen, Paavo; Wikgren, Jan; Koch, Lauren G.; Britton, Steven L.; Kainulainen, Heikki; Pekkala, Satu; Nokia, Miriam S. (Elsevier BV, 2021)BACKGROUND Increasing evidence shows obesity and poor metabolic health are associated with cognitive deficits, but the mechanistic connections have yet to be resolved. We studied rats selectively bred for low and high ... -
Cognitive performance and its associations with physical fitness and demographic and socio-economic variables in healthy aging
Vesikukka, Miia (2016)TIIVISTELMÄ Kognitiivinen suoriutuminen ja sen yhteydet fyysiseen kuntoon ja demografisiin ja sosioekonomisiin taustatekijöihin terveesti ikääntyvillä naisilla Tämä pro gradu –tutkielma tarkasteli terveen ikääntymisen ... -
Association between osteocalcin and cognitive performance in healthy older adults
Bradburn, Steven; McPhee, Jamie S.; Bagley, Liam; Sipilä, Sarianna; Stenroth, Lauri; Narici, Marco Vincenzo; Pääsuke, Mati; Gapeyeva, Helena; Osborne, Gabrielle; Sassano, Lorraine; Meskers, Carel G. M.; Maier, Andrea B.; Hogrel, Jean-Yves; Barnouin, Yoann; Butler-Browne, Gillian; Murgatroyd, Chris (Oxford University Press; British Geriatrics Society, 2016)Introduction: cognitive deterioration and reductions of bone health coincide with increasing age. We examine the relationship between bone composition and plasma markers of bone remodelling with measures of cognitive ...