Näytä suppeat kuvailutiedot

dc.contributor.authorTorvinen, Sira
dc.contributor.authorSilvennoinen, Mika
dc.contributor.authorPiitulainen, Harri
dc.contributor.authorNärväinen, Johanna
dc.contributor.authorTuunanen, Pasi
dc.contributor.authorGröhn, Olli
dc.contributor.authorKoch, Lauren G.
dc.contributor.authorBritton, Steven L.
dc.contributor.authorKainulainen, Heikki
dc.date.accessioned2012-11-27T07:46:08Z
dc.date.available2012-11-27T07:46:08Z
dc.date.issued2012fi
dc.identifier.citationTorvinen, S., Silvennoinen, M., Piitulainen, H., Närväinen, J., Tuunanen, P., Gröhn, O., . . . Kainulainen, H. (2012). Rats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractions. <em>PLoS One</em>, 7 (11), e48345. <a href="http://dx.doi.org/10.1371/journal.pone.0048345">doi:10.1371/journal.pone.0048345</a> Retrieved from <a href="http://dx.plos.org/10.1371/journal.pone.0048345">http://dx.plos.org/10.1371/journal.pone.0048345</a>fi
dc.identifier.otherTUTKAID_52574
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/40438
dc.description.abstractAIM. Muscular fatigue is a complex phenomenon affected by muscle fiber type and several metabolic and ionic changes within myocytes. Mitochondria are the main determinants of muscle oxidative capacity which is also one determinant of muscle fatigability. By measuring the concentrations of intracellular stores of high-energy phosphates it is possible to estimate the energy production efficiency and metabolic recovery of the muscle. Low intrinsic aerobic capacity is known to be associated with reduced mitochondrial function. Whether low intrinsic aerobic capacity also results in slower metabolic recovery of skeletal muscle is not known. Here we studied the influence of intrinsic aerobic capacity on in vivo muscle metabolism during maximal, fatiguing electrical stimulation. METHODS. Animal subjects were genetically heterogeneous rats selectively bred to differ for non–trained treadmill running endurance, low capacity runners (LCRs) and high capacity runners (HCRs) (n = 15–19). We measured the concentrations of major phosphorus compounds and force parameters in a contracting triceps surae muscle complex using 31P-Magnetic resonance spectroscopy (31P-MRS) combined with muscle force measurement from repeated isometric twitches. RESULTS. Our results demonstrated that phosphocreatine re-synthesis after maximal muscle stimulation was significantly slower in LCRs (p<0.05). LCR rats also became promptly fatigued and maintained the intramuscular pH poorly compared to HCRs. Half relaxation time (HRT) of the triceps surae was significantly longer in LCRs throughout the stimulation protocol (p≤0.05) and maximal rate of torque development (MRTD) was significantly lower in LCRs compared to HCRs from 2 min 30 s onwards (p≤0.05). CONCLUSION. We observed that LCRs are more sensitive to fatigue and have slower metabolic recovery compared to HCRs after maximal muscle contractions. These new findings are associated with reduced running capacity and with previously found lower mitochondrial content, increased body mass and higher complex disease risk of LCRs.fi
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLOS ONE
dc.relation.urihttp://dx.plos.org/10.1371/journal.pone.0048345
dc.subject.otheraerobinen kapasiteetti
dc.subject.othermetaboliset sairaudet
dc.subject.otherraajalihas
dc.subject.othersupistusominaisuudet
dc.subject.otheraerobic capacity
dc.subject.othercomplex disease
dc.subject.othercontractile properties
dc.subject.otherskeletal muscle
dc.titleRats bred for low aerobic capacity become promptly fatigued and have slow metabolic recovery after stimulated, maximal muscle contractionsfi
dc.typeArticle
dc.identifier.urnURN:NBN:fi:jyu-201211273078
dc.contributor.laitosLiikuntabiologian laitos
dc.contributor.laitosDepartment of Biology of Physical Activityen
dc.contributor.oppiaineLiikuntafysiologia
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.identifier.doi10.1371/journal.pone.0048345
dc.date.updated2012-11-27T04:30:34Z
dc.type.coarjournal article
dc.description.reviewstatuspeerReviewed
dc.format.pagerangee48345
dc.relation.issn1932-6203
dc.relation.numberinseries11
dc.relation.volume7
dc.type.versionpublishedVersion
dc.rights.copyright© 2012 Torvinen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.accesslevelopenAccessfi
dc.rights.urlhttp://creativecommons.org/licenses/by/2.5/


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

© 2012 Torvinen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Ellei muuten mainita, aineiston lisenssi on © 2012 Torvinen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.