The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer
Jääskeläinen, M. M., Tiainen, S., Siiskonen, H., Ahtiainen, M., Kuopio, T., Rönkä, A., Kettunen, T., Hämäläinen, K., Rilla, K., Harvima, I., Mannermaa, A., & Auvinen, P. (2023). The prognostic and predictive role of tumor-infiltrating lymphocytes (FoxP3 + and CD8 +) and tumor-associated macrophages in early HER2 + breast cancer. Breast Cancer Research and Treatment, 201(183-192). https://doi.org/10.1007/s10549-023-07017-8
Julkaistu sarjassa
Breast Cancer Research and TreatmentTekijät
Päivämäärä
2023Tekijänoikeudet
© The Author(s) 2023
Purpose
In HER2-positive (HER2 +) breast cancer, tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs) may influence the efficacy of the HER2-antibody trastuzumab and the patient’s outcome. In this HER2 + patient cohort, our aim was to study the numbers of FoxP3 + regulatory TILs and CD8 + cytotoxic TILs, their correlations with CD68 + and CD163 + TAMs, and the prognostic and predictive value of the studied factors.
Methods
We evaluated 139 non-metastatic HER2 + breast cancer patients operated between 2001 and 2008. The FoxP3+TIL count (FoxP3+TILs) was assessed using the hotspot method, and the CD8 + TIL count (CD8+mTILs) utilizing a digital image analysis from invasive margin areas. The ratios between CD8+mTILs and FoxP3+TILs as well as CD8+mTILs and TAMs were calculated.
Results
FoxP3 + TILs and CD8 + mTILs correlated positively with each other (p<0.001). FoxP3+TILs had a positive correlation with CD68+and CD163+TAMs (p≤0.038), while CD8 + mTILs correlated only with CD68+TAMs (p<0.001). In the HER2 + and hormone receptor-positive Luminal B subgroup, high numbers of FoxP3+TILs were associated with shorter disease-free survival (DFS) (54% vs. 79%, p = 0.040). The benefit from adjuvant trastuzumab was extremely significant among patients with a high CD8 + mTILs/CD68 + TAMs ratio, with overall survival (OS) 84% vs. 33% (p = 0.003) and breast cancer-specific survival (BCSS) 88% vs. 48% (p = 0.009) among patients treated with or without trastuzumab, respectively.
Conclusion
In the HER2 + Luminal B subgroup, high FoxP3 + TILs were associated with shorter DFS. A high CD8 + mTILs/CD68 + TAMs ratio seems to associate with impressive efficacy of trastuzumab.
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Julkaisija
SpringerISSN Hae Julkaisufoorumista
0167-6806Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/183965779
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Lisätietoja rahoituksesta
Open access funding provided by University of Eastern Finland (UEF) including Kuopio University Hospital. This study was supported by grants from the Finnish Cultural Foundation (Grant Number 65202120) and Kuopio University Hospital Research Foundation.Lisenssi
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