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dc.contributor.authorTait, Jamie L.
dc.contributor.authorDuckham, Rachel L.
dc.contributor.authorRantalainen, Timo
dc.contributor.authorMilte, Catherine M.
dc.contributor.authorMain, Luana C.
dc.contributor.authorNowson, Caryl A.
dc.contributor.authorSanders, Kerrie M.
dc.contributor.authorTaaffe, Dennis R.
dc.contributor.authorHill, Keith D.
dc.contributor.authorAbbott, Gavin
dc.contributor.authorDaly, Robin M.
dc.date.accessioned2024-09-11T08:59:20Z
dc.date.available2024-09-11T08:59:20Z
dc.date.issued2024
dc.identifier.citationTait, J. L., Duckham, R. L., Rantalainen, T., Milte, C. M., Main, L. C., Nowson, C. A., Sanders, K. M., Taaffe, D. R., Hill, K. D., Abbott, G., & Daly, R. M. (2024). Effects of a 6-month dual-task, power-based exercise program on cognitive function, neurological and inflammatory markers in older adults : secondary analysis of a cluster randomised controlled trial. <i>GeroScience</i>, <i>Early online</i>. <a href="https://doi.org/10.1007/s11357-024-01316-8" target="_blank">https://doi.org/10.1007/s11357-024-01316-8</a>
dc.identifier.otherCONVID_241746522
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/97024
dc.description.abstractFunctional power-based exercise training can improve physical performance in older adults and cognitive training can improve measures of cognition, but their combined effects on cognition and related risk factors (neurological and inflammatory markers) remains uncertain. This 6-month cluster randomised controlled trial evaluated the effectiveness of dual-task functional power training (DT-FPT) on cognition and circulating neurological and inflammatory markers in older adults at increased falls risk, and whether intervention responses varied by apolipoprotein-E (ApoE) and brain derived neurotrophic factor (BDNF) polymorphisms. Three hundred residents aged ≥ 65 years at increased falls risk residing in 22 independent-living retirement communities, were randomised by village, to DT-FPT (n = 156, 11 villages) involving a multi-component power-based training program performed simultaneously with cognitive and/or motor tasks (45–60 min, 2/week), or a usual care control (CON) group (n = 144, 11 villages). Cognition (computerized CogState battery), inflammatory cytokines, BDNF, insulin-like growth factor-1, vascular endothelial growth factor, amyloid β (1–40) and (1–42) were assessed at baseline and 6-months. Overall, 233 (78%) participants completed the intervention and adherence averaged 50.1%. DT-FPT led to a net 0.18–0.20 SD benefit versus CON in psychomotor ability/attention and reaction time/attention (both P < 0.05). There were no significant intervention effects on circulating markers, except for a net 10.5% benefit in amyloid β (1–40) in DT-FPT versus CON (P < 0.05). Responses were not influenced by APOE or BDNF genotype. In conclusion, DT-FPT in older adults at increased falls risk can provide some cognitive benefits, but these were not related to corresponding changes in inflammatory or neurological markers or influenced by genotype. Australian New Zealand Clinical Trials Registry (ACTRN12613001161718). http://www.anzctr.org.au/ This project was funded by a grant from the National Health and Medical Research Council (NHMRC) Project (APP1046267).en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofseriesGeroScience
dc.rightsCC BY 4.0
dc.subject.otherdual-task training
dc.subject.othercognition
dc.subject.otherageing
dc.subject.othercytokine
dc.subject.otherphysical activity
dc.titleEffects of a 6-month dual-task, power-based exercise program on cognitive function, neurological and inflammatory markers in older adults : secondary analysis of a cluster randomised controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202409115904
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2509-2715
dc.relation.volumeEarly online
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2024
dc.rights.accesslevelopenAccessfi
dc.subject.ysoikääntyminen
dc.subject.ysokognitio
dc.subject.ysoikääntyneet
dc.subject.ysofyysinen aktiivisuus
dc.subject.ysovoimaharjoittelu
dc.subject.ysosytokiinit
dc.subject.ysokognitiiviset taidot
dc.subject.ysomatala-asteinen tulehdus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p5056
jyx.subject.urihttp://www.yso.fi/onto/yso/p642
jyx.subject.urihttp://www.yso.fi/onto/yso/p2433
jyx.subject.urihttp://www.yso.fi/onto/yso/p23102
jyx.subject.urihttp://www.yso.fi/onto/yso/p16233
jyx.subject.urihttp://www.yso.fi/onto/yso/p22729
jyx.subject.urihttp://www.yso.fi/onto/yso/p24920
jyx.subject.urihttp://www.yso.fi/onto/yso/p39497
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s11357-024-01316-8
jyx.fundinginformationThis project was funded by a grant from the National Health and Medical Research Council (NHMRC) Project (APP1046267).
dc.type.okmA1


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