Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT : secondary analysis of a 12-month randomised controlled trial
Mundell, N. L., Owen, P. J., Dalla, V. J., Macpherson, H., Daly, R., Livingston, P. M., Rantalainen, T., Foulkes, S., Millar, J., Murphy, D. G., & Fraser, S. (2022). Effects of a multicomponent resistance-based exercise program with protein, vitamin D and calcium supplementation on cognition in men with prostate cancer treated with ADT : secondary analysis of a 12-month randomised controlled trial. BMJ Open, 12(6), Article e060189. https://doi.org/10.1136/bmjopen-2021-060189
Published inBMJ Open
© Author(s) (or their employer(s)) 2022.
Objectives The aim of this preplanned secondary analysis of a 12-month randomised controlled trial was to investigate the effects of a multicomponent exercise programme combined with daily whey protein, calcium and vitamin D supplementation on cognition in men with prostate cancer treated with androgen deprivation therapy (ADT). Design 12-month, two-arm, randomised controlled trial. Setting University clinical exercise centre. Participants 70 ADT-treated men were randomised to exercise-training plus supplementation (Ex+ Suppl, n=34) or usual care (control, n=36). Intervention Men allocated to Ex + Suppl undertook thrice weekly resistance training with weight-bearing exercise training plus daily whey protein (25 g), calcium (1200 mg) and vitamin D (2000 IU) supplementation. Primary and secondary outcome measures Cognition was assessed at baseline, 6 and 12 months via a computerised battery (CogState), Trail-making test, Rey auditory-verbal learning test and Digit span. Data were analysed with linear mixed models and an intention-to-treat and prespecified per-protocol approach (exercise-training: ≥66%, nutritional supplement: ≥80%). Results Sixty (86%) men completed the trial (Ex + Suppl, n=31; control, n=29). Five (7.1%) men were classified as having mild cognitive impairment at baseline. Median (IQR) adherence to the exercise and supplement was 56% (37%–82%) and 91% (66%–97%), respectively. Ex + Suppl had no effect on cognition at any time. Conclusions A 12-month multicomponent exercise training and supplementation intervention had no significant effect on cognition in men treated with ADT for prostate cancer compared with usual care. Exercise training adherence below recommended guidelines does not support cognitive health in men treated with ADT for prostate cancer. Trial registration number Australian and New Zealand Clinical Trial Registry (ACTRN12614000317695, registered 25/03/2014) and acknowledged under the Therapeutic Goods Administration Clinical Trial Notification Scheme (CT-2015-CTN-03372-1 v1). ...
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Additional information about fundingThe study received in-kind support from YMCA Victoria, Ostelin and Omniblend. Facilities, equipment and internal funding were provided by Deakin University. RD has received funding from a Primary Growth Partnership grant via the Ministry of Primary Industries in New Zealand with Fonterra Co-operative Group Ltd. Declan G Murphy has received honoraria for advisory board and speaker duties from Astellas, Janssen, Astra Zeneca, Bayer, Ferring and Ipsen. ...
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Radiotherapy before or during androgen-deprivation therapy does not blunt the exercise-induced body composition protective effects in prostate cancer patients : A secondary analysis of two randomized controlled trials Newton, Robert U.; Mavropalias, Georgios; Fragala, Maren S.; Kraemer, William J.; Häkkinen, Keijo; Taaffe, Dennis R.; Spry, Nigel; Joseph, David; Galvão, Daniel A. (Elsevier, 2021)Background Androgen deprivation therapy (ADT) contributes to lean mass loss and adiposity increases in prostate cancer patients. Radiotherapy during ADT might act synergistically and further worsen body composition. ...
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