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dc.contributor.authorPauls, K. Amande M. .
dc.contributor.authorNurmi, Pietari
dc.contributor.authorAla-Salomäki, Heidi
dc.contributor.authorRenvall, Hanna
dc.contributor.authorKujala, Jan
dc.contributor.authorLiljeström, Mia
dc.date.accessioned2024-07-02T10:25:24Z
dc.date.available2024-07-02T10:25:24Z
dc.date.issued2024
dc.identifier.citationPauls, K. A. M. .., Nurmi, P., Ala-Salomäki, H., Renvall, H., Kujala, J., & Liljeström, M. (2024). Human sensorimotor resting state beta events and aperiodic signals response show good test-retest reliability. <i>Clinical Neurophysiology</i>, <i>163</i>, 244-254. <a href="https://doi.org/10.1016/j.clinph.2024.03.021" target="_blank">https://doi.org/10.1016/j.clinph.2024.03.021</a>
dc.identifier.otherCONVID_207756778
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/96280
dc.description.abstractObjective Diseases affecting sensorimotor function impair physical independence. Reliable functional clinical biomarkers allowing early diagnosis or targeting treatment and rehabilitation could reduce this burden. Magnetoencephalography (MEG) non-invasively measures brain rhythms such as the somatomotor ‘rolandic’ rhythm which shows intermittent high-amplitude beta (14-30Hz) ‘events’ that predict behavior across tasks and species and are altered by sensorimotor neurological diseases. Methods We assessed test-retest stability, a prerequisite for biomarkers, of spontaneous sensorimotor aperiodic (1/f) signal and beta events in 50 healthy human controls across two MEG sessions using the intraclass correlation coefficient (ICC). Beta events were determined using an amplitude-thresholding approach on a narrow-band filtered amplitude envelope obtained using Morlet wavelet decomposition. Results Resting sensorimotor characteristics showed good to excellent test-retest stability. Aperiodic component (ICC 0.77-0.88) and beta event amplitude (ICC 0.74-0.82) were very stable, whereas beta event duration was more variable (ICC 0.55-0.7). 2-3 minute recordings were sufficient to obtain stable results. Analysis automatization was successful in 86%. Conclusions Sensorimotor beta phenotype is a stable feature of an individual’s resting brain activity even for short recordings easily measured in patients. Significance Spontaneous sensorimotor beta phenotype has potential as a clinical biomarker of sensorimotor system integrity.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesClinical Neurophysiology
dc.rightsCC BY 4.0
dc.subject.othermagnetoencephalography
dc.subject.otherresting state
dc.subject.othersensorimotor
dc.subject.otherbeta oscillatory activity
dc.subject.otheraperiodic (1/f) activity
dc.subject.othertest-retest reliability
dc.titleHuman sensorimotor resting state beta events and aperiodic signals response show good test-retest reliability
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202407025108
dc.contributor.laitosPsykologian laitosfi
dc.contributor.laitosDepartment of Psychologyen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange244-254
dc.relation.issn1388-2457
dc.relation.volume163
dc.type.versionpublishedVersion
dc.rights.copyright© 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.
dc.rights.accesslevelopenAccessfi
dc.subject.ysomotoriikka
dc.subject.ysohermoston taudit
dc.subject.ysobiomarkkerit
dc.subject.ysokuntoutus
dc.subject.ysoMEG
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p496
jyx.subject.urihttp://www.yso.fi/onto/yso/p295
jyx.subject.urihttp://www.yso.fi/onto/yso/p12288
jyx.subject.urihttp://www.yso.fi/onto/yso/p3320
jyx.subject.urihttp://www.yso.fi/onto/yso/p3329
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1016/j.clinph.2024.03.021
jyx.fundinginformationWe acknowledge the following funding sources: AP received funding from the Academy of Finland (grant number 350242), the Sigrid Juselius Foundation and the Finnish Medical Foundation. Pietari Nurmi received funding from the Finnish Cultural Foundation and the Swedish Cultural Foundation in Finland. Heidi Ala-Salomäki received funding from the Jenny and Antti Wihuri foundation and the Finnish Cultural Foundation. HR received funding from the Academy of Finland (grant numbers 127401 and 321460). Mia Liljeström received funding from the Swedish Cultural Foundation in Finland.
dc.type.okmA1


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