Human sensorimotor resting state beta events and aperiodic signals response show good test-retest reliability
Pauls, K. A. M. .., Nurmi, P., Ala-Salomäki, H., Renvall, H., Kujala, J., & Liljeström, M. (2024). Human sensorimotor resting state beta events and aperiodic signals response show good test-retest reliability. Clinical Neurophysiology, 163, 244-254. https://doi.org/10.1016/j.clinph.2024.03.021
Published in
Clinical NeurophysiologyAuthors
Date
2024Copyright
© 2024 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.
Objective
Diseases affecting sensorimotor function impair physical independence. Reliable functional clinical biomarkers allowing early diagnosis or targeting treatment and rehabilitation could reduce this burden. Magnetoencephalography (MEG) non-invasively measures brain rhythms such as the somatomotor ‘rolandic’ rhythm which shows intermittent high-amplitude beta (14-30Hz) ‘events’ that predict behavior across tasks and species and are altered by sensorimotor neurological diseases.
Methods
We assessed test-retest stability, a prerequisite for biomarkers, of spontaneous sensorimotor aperiodic (1/f) signal and beta events in 50 healthy human controls across two MEG sessions using the intraclass correlation coefficient (ICC). Beta events were determined using an amplitude-thresholding approach on a narrow-band filtered amplitude envelope obtained using Morlet wavelet decomposition.
Results
Resting sensorimotor characteristics showed good to excellent test-retest stability. Aperiodic component (ICC 0.77-0.88) and beta event amplitude (ICC 0.74-0.82) were very stable, whereas beta event duration was more variable (ICC 0.55-0.7). 2-3 minute recordings were sufficient to obtain stable results. Analysis automatization was successful in 86%.
Conclusions
Sensorimotor beta phenotype is a stable feature of an individual’s resting brain activity even for short recordings easily measured in patients.
Significance
Spontaneous sensorimotor beta phenotype has potential as a clinical biomarker of sensorimotor system integrity.
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Publisher
ElsevierISSN Search the Publication Forum
1388-2457Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/207756778
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Additional information about funding
We acknowledge the following funding sources: AP received funding from the Academy of Finland (grant number 350242), the Sigrid Juselius Foundation and the Finnish Medical Foundation. Pietari Nurmi received funding from the Finnish Cultural Foundation and the Swedish Cultural Foundation in Finland. Heidi Ala-Salomäki received funding from the Jenny and Antti Wihuri foundation and the Finnish Cultural Foundation. HR received funding from the Academy of Finland (grant numbers 127401 and 321460). Mia Liljeström received funding from the Swedish Cultural Foundation in Finland. ...License
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