Genome assembly of the dyeing poison frog provides insights into the dynamics of transposable element and genome-size evolution
Dittrich, C., Hoelzl, F., Smith, S., Fouilloux, C. A., Parker, D. J., O’Connell, L. A., Knowles, L. S., Hughes, M., Fewings, A., Morgan, R., Rojas, B., & Comeault, A. A. (2024). Genome assembly of the dyeing poison frog provides insights into the dynamics of transposable element and genome-size evolution. Genome Biology and Evolution, 16(6), Article evae109. https://doi.org/10.1093/gbe/evae109
Julkaistu sarjassa
Genome Biology and EvolutionTekijät
Päivämäärä
2024Tekijänoikeudet
© The Author(s) 2024. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution
Genome size varies greatly across the tree of life and transposable elements are an important contributor to this variation. Among vertebrates, amphibians display the greatest variation in genome size, making them ideal models to explore the causes and consequences of genome size variation. However, high-quality genome assemblies for amphibians have, until recently, been rare. Here, we generate a high-quality genome assembly for the dyeing poison frog, Dendrobates tinctorius. We compare this assembly to publicly available frog genomes and find evidence for both large-scale conserved synteny and widespread rearrangements between frog lineages. Comparing conserved orthologs annotated in these genomes revealed a strong correlation between genome size and gene size. To explore the cause of gene-size variation, we quantified the location of transposable elements relative to gene features and find that the accumulation of transposable elements in introns has played an important role in the evolution of gene size in D. tinctorius, while estimates of insertion times suggest that many insertion events are recent and species-specific. Finally, we carry out population-scale mobile-element sequencing and show that the diversity and abundance of transposable elements in poison frog genomes can complicate genotyping from repetitive element sequence anchors. Our results show that transposable elements have clearly played an important role in the evolution of large genome size in D. tinctorius. Future studies are needed to fully understand the dynamics of transposable element evolution and to optimise primer or bait design for cost-effective population-level genotyping in species with large, repetitive genomes.
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Julkaisija
Oxford University PressISSN Hae Julkaisufoorumista
1759-6653Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/213720805
Metadata
Näytä kaikki kuvailutiedotKokoelmat
Rahoittaja(t)
Suomen AkatemiaRahoitusohjelmat(t)
Akatemiatutkijan tutkimuskulut, SA; Akatemiatutkija, SALisätietoja rahoituksesta
This work was supported by funding from the NERC Environmental Omics Facility (project number 1382 to AAC); Research Council of Finland (# 318404; 319949; 345974 to BR); and the National Science Foundation (IOS-1822025 and IOS-1827333 to LAO).Lisenssi
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