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dc.contributor.authorMayer, Jutta S.
dc.contributor.authorKohlhas, Laura
dc.contributor.authorStermann, Jacek
dc.contributor.authorMedda, Juliane
dc.contributor.authorBrandt, Geva A.
dc.contributor.authorGrimm, Oliver
dc.contributor.authorPawley, Adam D.
dc.contributor.authorAsherson, Philip
dc.contributor.authorPalacio Sanchez, Judit
dc.contributor.authorRicharte, Vanesa
dc.contributor.authorBergsma, Douwe
dc.contributor.authorKoch, Elena D.
dc.contributor.authorMuntaner-Mas, Adrià
dc.contributor.authorEbner-Priemer, Ulrich W.
dc.contributor.authorKieser, Meinhard
dc.contributor.authorRetz, Wolfgang
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorColla, Michael
dc.contributor.authorBuitelaar, Jan K.
dc.contributor.authorKuntsi, Jonna
dc.contributor.authorRamos-Quiroga, Josep A.
dc.contributor.authorReif, Andreas
dc.contributor.authorFreitag, Christine M.
dc.date.accessioned2024-05-02T09:16:11Z
dc.date.available2024-05-02T09:16:11Z
dc.date.issued2024
dc.identifier.citationMayer, J. S., Kohlhas, L., Stermann, J., Medda, J., Brandt, G. A., Grimm, O., Pawley, A. D., Asherson, P., Palacio Sanchez, J., Richarte, V., Bergsma, D., Koch, E. D., Muntaner-Mas, A., Ebner-Priemer, U. W., Kieser, M., Retz, W., Ortega, F. B., Colla, M., Buitelaar, J. K., . . . Freitag, C. M. (2024). Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder : a multicentre, three-arm, randomised controlled, pilot phase-IIa trial. <i>European Archives of Psychiatry and Clinical Neuroscience</i>, <i>Early online</i>. <a href="https://doi.org/10.1007/s00406-024-01784-1" target="_blank">https://doi.org/10.1007/s00406-024-01784-1</a>
dc.identifier.otherCONVID_213412300
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/94628
dc.description.abstractDepression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)—both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system—for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14–45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: −0.124 [95% CI: −2.219, 1.971], EI: −2.646 [95% CI: −4.777, −0.515], TAU: −1.428 [95% CI: −3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Science and Business Media LLC
dc.relation.ispartofseriesEuropean Archives of Psychiatry and Clinical Neuroscience
dc.rightsCC BY 4.0
dc.subject.otherAttention-deficit/hyperactivity disorder
dc.subject.otherDepression
dc.subject.otherObesity
dc.subject.otherBright light therapy
dc.subject.otherPhysical exercise
dc.subject.otherm-Health
dc.subject.otherRandomised controlled trial
dc.titleBright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder : a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202405023254
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn0940-1334
dc.relation.volumeEarly online
dc.type.versionpublishedVersion
dc.rights.copyright© 2024 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysosatunnaistetut vertailukokeet
dc.subject.ysonuoret aikuiset
dc.subject.ysointerventiohoito
dc.subject.ysonuoret
dc.subject.ysoADHD
dc.subject.ysoliikuntahoito
dc.subject.ysomasennus
dc.subject.ysokirkasvalohoito
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p38295
jyx.subject.urihttp://www.yso.fi/onto/yso/p15979
jyx.subject.urihttp://www.yso.fi/onto/yso/p19526
jyx.subject.urihttp://www.yso.fi/onto/yso/p11617
jyx.subject.urihttp://www.yso.fi/onto/yso/p4541
jyx.subject.urihttp://www.yso.fi/onto/yso/p7811
jyx.subject.urihttp://www.yso.fi/onto/yso/p7995
jyx.subject.urihttp://www.yso.fi/onto/yso/p24068
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1007/s00406-024-01784-1
jyx.fundinginformationOpen Access funding enabled and organized by Projekt DEAL. The research has received funding from the EU Framework Programme for Research and Innovation, Horizon 2020 under grant agreement no. 667303 (CoCA). F.B.O. research activity was also supported by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS). The funding sources had no role in study design, data collection, data analysis, data interpretation, or writing of the report.
dc.type.okmA1


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