Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder : a multicentre, three-arm, randomised controlled, pilot phase-IIa trial
Mayer, J. S., Kohlhas, L., Stermann, J., Medda, J., Brandt, G. A., Grimm, O., Pawley, A. D., Asherson, P., Palacio Sanchez, J., Richarte, V., Bergsma, D., Koch, E. D., Muntaner-Mas, A., Ebner-Priemer, U. W., Kieser, M., Retz, W., Ortega, F. B., Colla, M., Buitelaar, J. K., . . . Freitag, C. M. (2024). Bright light therapy versus physical exercise to prevent co-occurring depression in adolescents and young adults with attention-deficit/hyperactivity disorder : a multicentre, three-arm, randomised controlled, pilot phase-IIa trial. European Archives of Psychiatry and Clinical Neuroscience, Early online. https://doi.org/10.1007/s00406-024-01784-1
Julkaistu sarjassa
European Archives of Psychiatry and Clinical NeuroscienceTekijät
Päivämäärä
2024Tekijänoikeudet
© 2024 the Authors
Depression is common in attention-deficit/hyperactivity disorder (ADHD), but preventive behavioural interventions are lacking. This randomised controlled, pilot phase-IIa trial aimed to study a physical exercise intervention (EI) and bright light therapy (BLT)—both implemented and monitored in an individual, naturalistic setting via a mobile health (m-health) system—for feasibility of trial design and interventions, and to estimate their effects on depressive symptoms in young people with ADHD. Two hundred seven participants aged 14–45 years were randomised to 10-week add-on intervention of either BLT (10,000 lx; daily 30-min sessions) (n = 70), EI (aerobic and muscle-strengthening activities 3 days/ week) (n = 69), or treatment-as-usual (TAU) (n = 68), of whom 165 (80%) were retained (BLT: n = 54; EI: n = 52; TAU: n = 59). Intervention adherence (i.e. ≥ 80% completed sessions) was very low for both BLT (n = 13, 22%) and EI (n = 4, 7%). Usability of the m-health system to conduct interventions was limited as indicated by objective and subjective data. Safety was high and comparable between groups. Changes in depressive symptoms (assessed via observer-blind ratings, Inventory of Depressive Symptomatology) between baseline and end of intervention were small (BLT: −0.124 [95% CI: −2.219, 1.971], EI: −2.646 [95% CI: −4.777, −0.515], TAU: −1.428 [95% CI: −3.381, 0.526]) with no group differences [F(2,153) = 1.45, p = 0.2384]. These findings suggest that the m-health approach did not achieve feasibility of EI and BLT in young people with ADHD. Prior to designing efficacy studies, strategies how to achieve high intervention adherence should be specifically investigated in this patient group.
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Julkaisija
Springer Science and Business Media LLCISSN Hae Julkaisufoorumista
0940-1334Asiasanat
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https://converis.jyu.fi/converis/portal/detail/Publication/213412300
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Open Access funding enabled and organized by Projekt DEAL. The research has received funding from the EU Framework Programme for Research and Innovation, Horizon 2020 under grant agreement no. 667303 (CoCA). F.B.O. research activity was also supported by the University of Granada, Plan Propio de Investigación 2016, Excellence actions: Unit of Excellence on Exercise, Nutrition and Health (UCEENS). The funding sources had no role in study design, data collection, data analysis, data interpretation, or writing of the report. ...Lisenssi
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