Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids
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Yedigenov, M., Amire, N., Abdirassil, A., Mulikova, T., Begenov, A., Kiesilä, A., Peshkov, A. A., Peshkov, V. A., & Utepbergenov, D. (2024). Glyoxalase-based toolbox for the enantioselective synthesis of α-hydroxy carboxylic acids. Organic and Biomolecular Chemistry, Advance Article. https://doi.org/10.1039/D3OB02098C
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Organic and Biomolecular ChemistryDate
2024Access restrictions
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© 2024 Royal Society of Chemistry
We report highly enantioselective synthesis of L-α-hydroxy carboxylic acids (L-αHCAs) via enzymatic intramolecular Cannizzaro reaction of (hetero)aryl glyoxals in the presence of glutathione-independent human glyoxalase DJ-1. Combined with the optimized synthesis of D-αHCAs using glyoxalases I and II, this approach offers a general, scalable and operationally simple access to both enantiomers of α-hydroxy acids in moderate to excellent yields with uniformly high enantioselectivity.
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Royal Society of ChemistryISSN Search the Publication Forum
1477-0520Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/207171021
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This work was supported by Nazarbayev University CRP grant 091019CRP2121 to D. U. and FDCRGP grant 11022021FD2903 to V. P.License
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