Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children : the PANIC study
Laamanen, S. E., Eloranta, A.-M., Haapala, E. A., Sallinen, T., Schwab, U., & Lakka, T. A. (2024). Associations of diet quality and food consumption with serum biomarkers for lipid and amino acid metabolism in Finnish children : the PANIC study. European Journal of Nutrition, 63(2), 623-637. https://doi.org/10.1007/s00394-023-03293-8
Published in
European Journal of NutritionAuthors
Date
2024Copyright
© The Author(s) 2023
Purpose
To investigate the associations of overall diet quality and dietary factors with serum biomarkers for lipid and amino acid metabolism in a general population of children.
Methods
We studied 194 girls and 209 boys aged 6–8 years participating in the Physical Activity and Nutrition in Children study. Food consumption was assessed by 4-day food records and diet quality was quantified by the Finnish Children Healthy Eating Index (FCHEI). Fasting serum fatty acids, amino acids, apolipoproteins, as well as lipoprotein particle sizes were analyzed with high-throughput nuclear magnetic resonance spectroscopy. Data were analyzed using linear regression adjusted for age, sex, and body fat percentage.
Results
FCHEI was directly associated with the ratio of polyunsaturated (PUFA) to saturated fatty acids (SFA) (PUFA/SFA), the ratio of PUFA to monounsaturated fatty acids (MUFA) (PUFA/MUFA), the ratio of PUFA to total fatty acids (FA) (PUFA%), the ratio of omega-3-fatty acids to total FA (omega-3 FA%), and inversely associated with the ratio of MUFA to total FA (MUFA%), alanine, glycine, histidine and very-low density lipoprotein (VLDL) particle size. Consumption of vegetable oils and vegetable-oil-based margarine (≥ 60% fat) was directly associated with PUFA/SFA, PUFA/MUFA, PUFA%, the ratio of omega-6 FA to total FA (omega-6 FA%), and inversely associated with SFA, MUFA, SFA to total FA (SFA%), MUFA%, alanine and VLDL particle size. Consumption of high-fiber grain products directly associated with PUFA/SFA, PUFA/MUFA, omega-3 FA%, omega-6 FA%, PUFA% and inversely associated with SFA and SFA%. Fish consumption directly related to omega-3 FA and omega-3 FA%. Consumption of sugary products was directly associated with histidine and VLDL particle size. Vegetable, fruit, and berry consumption had direct associations with VLDL particle size and the ratio of apolipoprotein B to apolipoprotein A1. Consumption of low fat (< 1%) milk was directly associated with phenylalanine. A higher consumption of high-fat (≥ 1%) milk was associated with lower serum MUFA/SFA and higher SFA%. Sausage consumption was directly related to SFA% and histidine. Red meat consumption was inversely associated with glycine.
Conclusions
Better diet quality, higher in intake of dietary sources of unsaturated fat and fiber, and lower in sugary product intake were associated with more favorable levels of serum biomarkers for lipid and amino acid metabolism independent of adiposity.
...
Publisher
SpringerISSN Search the Publication Forum
1436-6207Keywords
Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/197505840
Metadata
Show full item recordCollections
- Liikuntatieteiden tiedekunta [3130]
Additional information about funding
Open access funding provided by University of Eastern Finland (including Kuopio University Hospital). The PANIC study has been supported financially by grants from Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Academy of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Paediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. The funding sources have not been involved in designing the study, collecting the data, analyzing the data, interpreting the results, writing the manuscript, or deciding to submit the paper for publication. ...License
Related items
Showing items with similar title or keywords.
-
The effects of a 2-year physical activity and dietary intervention on plasma lipid concentrations in children : the PANIC Study
Eloranta, Aino-Maija; Sallinen, Taisa; Viitasalo, Anna; Lintu, Niina; Väistö, Juuso; Jalkanen, Henna; Tompuri, Tuomo T.; Soininen, Sonja; Haapala, Eero A.; Kiiskinen, Sanna; Schnurr, Theresia M.; Kilpeläinen, Tuomas O.; Mikkonen, Santtu; Savonen, Kai; Atalay, Mustafa; Brage, Soren; Laaksonen, David E.; Lindi, Virpi; Ågren, Jyrki; Schwab, Ursula; Jääskeläinen, Jarmo; Lakka, Timo A. (Springer, 2021)Purpose: We studied the effects of a physical activity and dietary intervention on plasma lipids in a general population of children. We also investigated how lifestyle changes contributed to the intervention effects. ... -
Human HDL subclasses modulate energy metabolism in skeletal muscle cells
Lund, Jenny; Lähteenmäki, Emilia; Eklund, Tiia; Bakke, Hege G.; Thoresen, G. Hege; Pirinen, Eija; Jauhiainen, Matti; Rustan, Arild C.; Lehti, Maarit (Elsevier, 2024)In addition to its anti-atherogenic role, HDL reportedly modulates energy metabolism at the whole-body level. HDL functionality is associated with its structure and composition, and functional activities can differ between ... -
Associations of physical activity, sedentary time, and diet quality with biomarkers of inflammation in children
Haapala, Eero A.; Väistö, Juuso; Ihalainen, Johanna K.; Tomaselli González, Claudia; Leppänen, Marja H.; Veijalainen, Aapo; Sallinen, Taisa; Eloranta, Aino-Maija; Ekelund, Ulf; Schwab, Ursula; Brage, Soren; Atalay, Mustafa; Lakka, Timo A. (Taylor & Francis, 2022)We investigated the associations of physical activity (PA), sedentary time (ST), and diet quality with biomarkers of inflammation in 390 children (192 girls, 198 boys) aged 6-8 years. PA energy expenditure (PAEE), light ... -
An Overview on the Associations between Health Behaviors and Brain Health in Children and Adolescents with Special Reference to Diet Quality
Naveed, Sehrish; Lakka, Timo; Haapala, Eero A. (MDPI, 2020)Unhealthy diet has been associated with overweight, obesity, increased cardiometabolic risk, and recently, to impaired cognition and academic performance. The aim of this review is to provide an overview of the associations ... -
Differences in specific abdominal fat depots between metabolically healthy and unhealthy children with overweight/obesity : The role of cardiorespiratory fitness
Cadenas‐Sanchez, Cristina; Medrano, María; Villanueva, Arantxa; Cabeza, Rafael; Idoate, Fernando; Osés, Maddi; Rodríguez‐Vigil, Beatriz; Álvarez de Eulate, Natalia; Alberdi Aldasoro, Nerea; Ortega, Francisco B.; Labayen, Idoia (Wiley, 2023)Objectives Fat depots localization has a critical role in the metabolic health status of adults. Nevertheless, whether that is also the case in children remains under-studied. Therefore, the aims of this study were: (i) ...