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dc.contributor.authorMartinez-Tellez, Borja
dc.contributor.authorSanchez-Delgado, Guillermo
dc.contributor.authorAcosta, Francisco M.
dc.contributor.authorAlcantara, Juan M. A.
dc.contributor.authorAmaro-Gahete, Francisco J.
dc.contributor.authorMartinez-Avila, Wendy D.
dc.contributor.authorMerchan-Ramirez, Elisa
dc.contributor.authorMuñoz-Hernandez, Victoria
dc.contributor.authorOsuna-Prieto, Francisco J.
dc.contributor.authorJurado-Fasoli, Lucas
dc.contributor.authorXu, Huiwen
dc.contributor.authorOrtiz-Alvarez, Lourdes
dc.contributor.authorArias-Tellez, María J.
dc.contributor.authorMendez-Gutierrez, Andrea
dc.contributor.authorLabayen, Idoia
dc.contributor.authorOrtega, Francisco B.
dc.contributor.authorSchönke, Milena
dc.contributor.authorRensen, Patrick C. N.
dc.contributor.authorAguilera, Concepción M.
dc.contributor.authorLlamas-Elvira, José M.
dc.contributor.authorGil, Ángel
dc.contributor.authorRuiz, Jonatan R.
dc.date.accessioned2023-10-06T12:35:16Z
dc.date.available2023-10-06T12:35:16Z
dc.date.issued2022
dc.identifier.citationMartinez-Tellez, B., Sanchez-Delgado, G., Acosta, F. M., Alcantara, J. M. A., Amaro-Gahete, F. J., Martinez-Avila, W. D., Merchan-Ramirez, E., Muñoz-Hernandez, V., Osuna-Prieto, F. J., Jurado-Fasoli, L., Xu, H., Ortiz-Alvarez, L., Arias-Tellez, M. J., Mendez-Gutierrez, A., Labayen, I., Ortega, F. B., Schönke, M., Rensen, P. C. N., Aguilera, C. M., . . . Ruiz, J. R. (2022). No evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial. <i>Nature Communications</i>, <i>13</i>, Article 5259. <a href="https://doi.org/10.1038/s41467-022-32502-x" target="_blank">https://doi.org/10.1038/s41467-022-32502-x</a>
dc.identifier.otherCONVID_189068661
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/89536
dc.description.abstractExercise modulates both brown adipose tissue (BAT) metabolism and white adipose tissue (WAT) browning in murine models. Whether this is true in humans, however, has remained unknown. An unblinded randomized controlled trial (ClinicalTrials.gov ID: NCT02365129) was therefore conducted to study the effects of a 24-week supervised exercise intervention, combining endurance and resistance training, on BAT volume and activity (primary outcome). The study was carried out in the Sport and Health University Research Institute and the Virgen de las Nieves University Hospital of the University of Granada (Spain). One hundred and forty-five young sedentary adults were assigned to either (i) a control group (no exercise, n = 54), (ii) a moderate intensity exercise group (MOD-EX, n = 48), or (iii) a vigorous intensity exercise group (VIG-EX n = 43) by unrestricted randomization. No relevant adverse events were recorded. 97 participants (34 men, 63 women) were included in the final analysis (Control; n = 35, MOD-EX; n = 31, and VIG-EX; n = 31). We observed no changes in BAT volume (Δ Control: −22.2 ± 52.6 ml; Δ MOD-EX: −15.5 ± 62.1 ml, Δ VIG-EX: −6.8 ± 66.4 ml; P = 0.771) or 18F-fluorodeoxyglucose uptake (SUVpeak Δ Control: −2.6 ± 3.1 ml; Δ MOD-EX: −1.2 ± 4.8, Δ VIG-EX: −2.2 ± 5.1; p = 0.476) in either the control or the exercise groups. Thus, we did not find any evidence of an exercise-induced change on BAT volume or activity in young sedentary adults.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesNature Communications
dc.rightsCC BY 4.0
dc.titleNo evidence of brown adipose tissue activation after 24 weeks of supervised exercise training in young sedentary adults in the ACTIBATE randomized controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202310065565
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2041-1723
dc.relation.volume13
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 the Authors
dc.rights.accesslevelopenAccessfi
dc.subject.ysoruskea rasva
dc.subject.ysorasvakudokset
dc.subject.ysoharjoittelu
dc.subject.ysoliikunta
dc.subject.ysonuoret aikuiset
dc.subject.ysosatunnaistetut vertailukokeet
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p38639
jyx.subject.urihttp://www.yso.fi/onto/yso/p24382
jyx.subject.urihttp://www.yso.fi/onto/yso/p26412
jyx.subject.urihttp://www.yso.fi/onto/yso/p916
jyx.subject.urihttp://www.yso.fi/onto/yso/p15979
jyx.subject.urihttp://www.yso.fi/onto/yso/p38295
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1038/s41467-022-32502-x
jyx.fundinginformationThis study was funded by the Spanish Ministry of Economy and Competitiveness via the Fondo de Investigación Sanitaria del Instituto de Salud Carlos III (PI13/01393; J.R.R.) and PTA-12264I, Retos de la Sociedad (DEP2016-79512-R; J.R.R.) and European Regional Development Funds (ERDF; J.R.R.), the Spanish Ministry of Education (FPU13/04365 (G.S.D.), FPU14/04172 (F.A.G.), FPU15/04059 (J.M.A.), FPU16/03653 (A.M.G.), FPU16/02828 (F.J.O.P.), FPU16/05159 (H.X.), FPU17/01523 (L.O.A.), FPU19/01609 (L.J.F.)), International Doctoral Studies Scholarship no. 440575 from the Mexican National Council of Science and Technology (CONACYT; WDMA), the Fundación Iberoamericana de Nutrición (FINUT; JRR), the Redes Temáticas de Investigación Cooperativa RETIC (Red SAMID RD16/0022; J.R.R.), the AstraZeneca HealthCare Foundation (J.R.R.), the University of Granada Plan Propio de Investigación 2016 -Excellence actions: Unit of Excellence on Exercise and Health (UCEES) (J.R.R.)- and Plan Propio de Investigación 2018 - Programa Contratos-Puente and Programa Perfecionamiento de Doctores (G.S.D.), the Junta de Andalucía, Consejería de Conocimiento, Investigación y Universidades (ERDF; ref. SOMM17/6107/UGR; JRR), the Junta de Andalucía, Consejería de Economía, Conocimiento, Empresas y Universidad (ref. P18-RT-4455; J.R.R.), the Fundación Alfonso Martín Escudero (B.M.T. and G.S.D.), the Maria Zambrano fellowship by the Ministerio de Universidades y la Unión Europea–NextGenerationEU (RR_C_2021_04; B.M.T.), and the Novo Nordisk Foundation (NNF18OC0032394; M.S.). This study was performed as part of a PhD thesis conducted within the Biomedicine Doctoral Studies Program of the University of Granada, Spain. The funding agencies had no role in study design, data collection and analysis or manuscript writing.
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