Show simple item record

dc.contributor.authorJaatela, Julia
dc.contributor.authorAydogan, Dogu Baran
dc.contributor.authorNurmi, Timo
dc.contributor.authorVallinoja, Jaakko
dc.contributor.authorMäenpää, Helena
dc.contributor.authorPiitulainen, Harri
dc.date.accessioned2023-08-21T11:41:09Z
dc.date.available2023-08-21T11:41:09Z
dc.date.issued2023
dc.identifier.citationJaatela, J., Aydogan, D. B., Nurmi, T., Vallinoja, J., Mäenpää, H., & Piitulainen, H. (2023). Limb-specific thalamocortical tracts are impaired differently in hemiplegic and diplegic subtypes of cerebral palsy. <i>Cerebral Cortex</i>, <i>33</i>(19), 10245-10257. <a href="https://doi.org/10.1093/cercor/bhad279" target="_blank">https://doi.org/10.1093/cercor/bhad279</a>
dc.identifier.otherCONVID_184246886
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/88610
dc.description.abstractThalamocortical pathways are considered crucial in the sensorimotor functioning of children with cerebral palsy (CP). However, previous research has been limited by non-specific tractography seeding and the lack of comparison between different CP subtypes. We compared limb-specific thalamocortical tracts between children with hemiplegic (HP, N = 15) or diplegic (DP, N = 10) CP and typically developed peers (N = 19). The cortical seed-points for the upper and lower extremities were selected (i) manually based on anatomical landmarks or (ii) using functional magnetic resonance imaging (fMRI) activations following proprioceptive-limb stimulation. Correlations were investigated between tract structure (mean diffusivity, MD; fractional anisotropy, FA; apparent fiber density, AFD) and sensorimotor performance (hand skill and postural stability). Compared to controls, our results revealed increased MD in both upper and lower limb thalamocortical tracts in the non-dominant hemisphere in HP and bilaterally in DP subgroup. MD was strongly lateralized in participants with hemiplegia, while AFD seemed lateralized only in controls. fMRI-based tractography results were comparable. The correlation analysis indicated an association between the white matter structure and sensorimotor performance. These findings suggest distinct impairment of functionally relevant thalamocortical pathways in HP and DP subtypes. Thus, the organization of thalamocortical white matter tracts may offer valuable guidance for targeted, life-long rehabilitation in children with CP.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherOxford University Press (OUP)
dc.relation.ispartofseriesCerebral Cortex
dc.rightsCC BY 4.0
dc.subject.otherdiffusion MRI
dc.subject.otherfMRI-seeding
dc.subject.othersensorimotor performance
dc.subject.otherstability
dc.subject.othertractography
dc.titleLimb-specific thalamocortical tracts are impaired differently in hemiplegic and diplegic subtypes of cerebral palsy
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202308214708
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange10245-10257
dc.relation.issn1047-3211
dc.relation.numberinseries19
dc.relation.volume33
dc.type.versionpublishedVersion
dc.rights.copyright© The Author(s) 2023. Published by Oxford University Press
dc.rights.accesslevelopenAccessfi
dc.relation.grantnumber327288
dc.relation.grantnumber311877
dc.relation.grantnumber326988
dc.subject.ysoCP-oireyhtymä
dc.subject.ysokuntoutus
dc.subject.ysotoiminnallinen magneettikuvaus
dc.subject.ysomagneettikuvaus
dc.subject.ysoaivohalvaus
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p13394
jyx.subject.urihttp://www.yso.fi/onto/yso/p3320
jyx.subject.urihttp://www.yso.fi/onto/yso/p24211
jyx.subject.urihttp://www.yso.fi/onto/yso/p12131
jyx.subject.urihttp://www.yso.fi/onto/yso/p6354
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1093/cercor/bhad279
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderResearch Council of Finlanden
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
dc.relation.funderSuomen Akatemiafi
jyx.fundingprogramResearch costs of Academy Research Fellow, AoFen
jyx.fundingprogramResearch profiles, AoFen
jyx.fundingprogramAcademy Research Fellow, AoFen
jyx.fundingprogramAkatemiatutkijan tutkimuskulut, SAfi
jyx.fundingprogramProfilointi, SAfi
jyx.fundingprogramAkatemiatutkija, SAfi
jyx.fundinginformationThis work was supported by Jane and Aatos Erkko Foundation (grant number 602.274 to H.P.); Academy of Finland (grant numbers 296240, 326988, 307250, 327288 to H.P.) and Emil Aaltonen Foundation (grant number 210044 to J.J.) Further, this study was supported by the Academy of Finland “Brain changes across the life-span” profiling funding to University of Jyväskylä (grant number 311877).
dc.type.okmA1


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

CC BY 4.0
Except where otherwise noted, this item's license is described as CC BY 4.0