Altered corpus callosum structure in adolescents with cerebral palsy : connection to gait and balance
Jaatela, J., Nurmi, T., Vallinoja, J., Mäenpää, H., Sairanen, V., & Piitulainen, H. (2023). Altered corpus callosum structure in adolescents with cerebral palsy : connection to gait and balance. Brain Structure and Function, 228, 1901-1915. https://doi.org/10.1007/s00429-023-02692-1
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Brain Structure and FunctionAuthors
Date
2023Copyright
© The Author(s) 2023
Cerebral palsy (CP) is the most common motor disorder in childhood. Recent studies in children with CP have associated weakened sensorimotor performance with impairments in the major brain white-matter (WM) structure, corpus callosum (CC). However, the relationship between CC structure and lower extremity performance, specifcally gait and balance, remains unknown. This study investigated the transcallosal WM structure and lower limb motor stability performance in adolescents aged 10–18 years with spastic hemiplegic (n=18) or diplegic (n=13) CP and in their age-matched controls (n=34). The modern difusion-weighted MRI analysis included the difusivity properties of seven CC subparts and the transcallosal lower limb sensorimotor tract of the dominant hemisphere. Children with CP had comprehensive impairments in the cross-sectional area, fractional anisotropy, and mean difusivity of the CC and sensorimotor tract. Additionally, the extent of WM alterations varied between hemiplegic and diplegic subgroups, which was seen especially in the fractional anisotropy values along the sensorimotor tract. The difusion properties of transcallosal WM were further associated with static stability in all groups, and with dynamic stability in healthy controls. Our novel results clarify the mechanistic role of the corpus callosum in adolescents with and without CP ofering valuable insight into the complex interplay between the brain’s WM organization and motor performance. A better understanding of the brain basis of weakened stability performance could, in addition, improve the specifcity of clinical diagnosis and targeted rehabilitation in CP.
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Springer Science and Business Media LLCISSN Search the Publication Forum
1863-2653Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/184672349
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Research Council of FinlandFunding program(s)
Research profiles, AoF; Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoFAdditional information about funding
Open Access funding provided by Aalto University. The work was supported by the Academy of Finland (Grant Numbers 296240, 326988, 307250, 327288) to author HP, and Jane and Aatos Erkko Foundation to author HP. Further, this study was supported by the Academy of Finland “Brain changes across the life-span” profling funding to University of Jyväskylä (Grant Number 311877).License
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