Functional connectivity of sensorimotor network is enhanced in spastic diplegic cerebral palsy : A multimodal study using fMRI and MEG
Vallinoja, J., Nurmi, T., Jaatela, J., Wens, V., Bourguignon, M., Mäenpää, H., & Piitulainen, H. (2024). Functional connectivity of sensorimotor network is enhanced in spastic diplegic cerebral palsy : A multimodal study using fMRI and MEG. Clinical Neurophysiology, 157, 4-14. https://doi.org/10.1016/j.clinph.2023.10.014
Published in
Clinical NeurophysiologyAuthors
Date
2024Copyright
© 2023 International Federation of Clinical Neurophysiology. Published by Elsevier B.V.
Objective
To assess the effects to functional connectivity (FC) caused by lesions related to spastic diplegic cerebral palsy (CP) in children and adolescents using multiple imaging modalities.
Methods
We used resting state magnetoencephalography (MEG) envelope signals in alpha, beta and gamma ranges and resting state functional magnetic resonance imaging (fMRI) signals to quantify FC between selected sensorimotor regions of interest (ROIs) in 11 adolescents with spastic diplegic cerebral palsy and 24 typically developing controls. Motor performance of the hands was quantified with gross motor, fine motor and kinesthesia tests.
Results
In fMRI, participants with CP showed enhanced FC within posterior parietal regions; in MEG, they showed enhanced interhemispheric FC between sensorimotor regions and posterior parietal regions both in alpha and lower beta bands. There was a correlation between the kinesthesia score and fronto-parietal connectivity in the control population.
Conclusions
CP is associated with enhanced FC in sensorimotor network. This difference is not correlated with hand coordination performance. The effect of the lesion is likely not fully captured by temporal correlation of ROI signals.
Significance
Brain lesions can show as increased temporal correlation of activity between remote brain areas. We suggest this effect is likely separate from typical physiological correlates of functional connectivity.
...
Publisher
ElsevierISSN Search the Publication Forum
1388-2457Keywords
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https://converis.jyu.fi/converis/portal/detail/Publication/194733528
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Related funder(s)
Research Council of FinlandFunding program(s)
Research costs of Academy Research Fellow, AoF; Academy Research Fellow, AoFAdditional information about funding
This study has been supported by the Academy of Finland “Brain changes across the life-span” profiling funding to University of Jyväskylä. HP was supported by Academy of Finland (grants #296240, #326988, #307250 and #327288) and Jane and Aatos Erkko Foundation. MEG research at the HUB–Hôpital Erasme is financially supported by the Fonds Erasme (Research Convention “Les Voies du Savoir”, Brussels, Belgium). MB was supported by the Fonds de la Recherche Scientifique (F.R.S.-FNRS, Brussels, Belgium; grant MIS F.4504.21). ...License
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