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dc.contributor.authorJyske, Tuula
dc.contributor.authorLiimatainen, Jaana
dc.contributor.authorTienaho, Jenni
dc.contributor.authorBrännström, Hanna
dc.contributor.authorAoki, Dan
dc.contributor.authorKuroda, Katsushi
dc.contributor.authorReshamwala, Dhanik
dc.contributor.authorKunnas, Susan
dc.contributor.authorHalmemies, Eelis
dc.contributor.authorNakayama, Eiko
dc.contributor.authorKilpeläinen, Petri
dc.contributor.authorOra, Ari
dc.contributor.authorKaseva, Janne
dc.contributor.authorHellström, Jarkko
dc.contributor.authorMarjomäki, Varpu S.
dc.contributor.authorKaronen, Maarit
dc.contributor.authorFukushima, Kazuhiko
dc.date.accessioned2023-05-24T08:51:02Z
dc.date.available2023-05-24T08:51:02Z
dc.date.issued2023
dc.identifier.citationJyske, T., Liimatainen, J., Tienaho, J., Brännström, H., Aoki, D., Kuroda, K., Reshamwala, D., Kunnas, S., Halmemies, E., Nakayama, E., Kilpeläinen, P., Ora, A., Kaseva, J., Hellström, J., Marjomäki, V. S., Karonen, M., & Fukushima, K. (2023). Inspired by nature : Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy. <i>Frontiers in Bioengineering and Biotechnology</i>, <i>11</i>, Article 1171908. <a href="https://doi.org/10.3389/fbioe.2023.1171908" target="_blank">https://doi.org/10.3389/fbioe.2023.1171908</a>
dc.identifier.otherCONVID_183159623
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/87141
dc.description.abstractThis study demonstrated the antibacterial and antiviral potential of condensed tannins and tannic acid when incorporated into fiber networks tested for functional material purposes. Condensed tannins were extracted from industrial bark of Norway spruce by using pressurized hot water extraction (PHWE), followed by purification of extracts by using XADHP7 treatment to obtain sugar-free extract. The chemical composition of the extracts was analyzed by using HPLC, GC‒MS and UHPLC after thiolytic degradation. The test matrices, i.e., lignocellulosic handsheets, were produced and impregnated with tannin-rich extracts, and tannic acid was used as a commercial reference. The antibacterial and antiviral efficacy of the handsheets were analyzed by using bioluminescent bacterial strains (Staphylococcus aureus RN4220+pAT19 and Escherichia coli K12+pCGLS11) and Enterovirus coxsackievirus B3. Potential bonding of the tannin-rich extract and tannic acid within the fiber matrices was studied by using FTIR-ATR spectroscopy. The deposition characteristics (distribution and accumulation patterns) of tannin compounds and extracts within fiber networks were measured and visualized by direct chemical mapping using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and digital microscopy. Our results demonstrated for the first time, how tannin-rich extracts obtained from spruce bark side streams with green chemistry possess antiviral and antibacterial properties when immobilized into fiber matrices to create substitutes for plastic hygienic products, personal protection materials such as surgical face masks, or food packaging materials to prolong the shelf life of foodstuffs and prevent the spread of infections. However, more research is needed to further develop this proof-of-concept to ensure stable chemical bonding in product prototypes with specific chemistry.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherFrontiers Media SA
dc.relation.ispartofseriesFrontiers in Bioengineering and Biotechnology
dc.rightsCC BY 4.0
dc.subject.otherantibacterial
dc.subject.otherantiviral
dc.subject.otherbark
dc.subject.othercellulose
dc.subject.otherphenolics
dc.subject.otherPicea abies
dc.subject.othersidestream
dc.subject.othertannins
dc.titleInspired by nature : Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202305243212
dc.contributor.laitosBio- ja ympäristötieteiden laitosfi
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Biological and Environmental Scienceen
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineSolu- ja molekyylibiologiafi
dc.contributor.oppiaineNanoscience Centerfi
dc.contributor.oppiaineCell and Molecular Biologyen
dc.contributor.oppiaineNanoscience Centeren
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn2296-4185
dc.relation.volume11
dc.type.versionpublishedVersion
dc.rights.copyright© 2023 Jyske, Liimatainen, Tienaho, Brännström, Aoki, Kuroda, Reshamwala, Kunnas, Halmemies, Nakayama, Kilpeläinen, Ora, Kaseva, Hellström, Marjomäki, Karonen and Fukushima
dc.rights.accesslevelopenAccessfi
dc.subject.ysoselluloosa
dc.subject.ysopuunkuori
dc.subject.ysoantimikrobiset yhdisteet
dc.subject.ysotoiminnalliset materiaalit
dc.subject.ysotanniinit
dc.subject.ysometsäkuusi
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p19012
jyx.subject.urihttp://www.yso.fi/onto/yso/p24500
jyx.subject.urihttp://www.yso.fi/onto/yso/p21949
jyx.subject.urihttp://www.yso.fi/onto/yso/p21221
jyx.subject.urihttp://www.yso.fi/onto/yso/p8755
jyx.subject.urihttp://www.yso.fi/onto/yso/p5552
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.3389/fbioe.2023.1171908
jyx.fundinginformationThis work was supported by the Academy of Finland’s Key Project funding “Forging ahead with Research” (InnoTrea project, decision no 305763), Academy of Finland’s project funding (ForestAntivirals project, decision no 342250), the Academy of Finland’s funding “Mobility from Finland” for T. Jyske (Inspired by nature project, decision no 316237), and the Business Finland “Co-Creation” and Co-Innovation fundings (Antiviral Fibers, decision no 40699/31/2020, and BIOPROT, decision no 4403/31/2021). The authors also gratefully acknowledge financial support from the project funded by the EU Interreg Botnia-Atlantica (TanWat) and Luke’s strategic research funding for project Added value potential of new and underutilized fiber sources in Finnish value networks of green bioeconomy: prefeasibility, prototyping, and market acceptance (VALUEPOT, no 4100-00180600). The authors acknowledge funding from the Jane and Aatos Erkko foundation (Broadly acting antivirals) and Business Finland “Research to Busines” funding (Natural antivirals) to Varpu Marjomäki group. The research mobility of E. Nakayama was supported by the Showa Women’s University Grant.
dc.type.okmA1


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