Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study
Haapala, E. A., Kuronen, E., Ihalainen, J. K., Lintu, N., Leppänen, M. H., Tompuri, T., Atalay, M., Schwab, U., & Lakka, T. A. (2023). Cross‐sectional associations between physical fitness and biomarkers of inflammation in children : the PANIC study. Scandinavian Journal of Medicine and Science in Sports, 33(6), 1000-1009. https://doi.org/10.1111/sms.14337
Julkaistu sarjassa
Scandinavian Journal of Medicine and Science in SportsTekijät
Päivämäärä
2023Oppiaine
BiomekaniikkaLiikuntalääketiedeLiikuntafysiologiaBiomechanicsSports and Exercise MedicineExercise PhysiologyTekijänoikeudet
© 2023 The Authors. Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd.
Background
Systemic low-grade inflammation has been proposed as an underlying pathophysiological mechanism for cardiometabolic diseases. We investigated the associations of physical fitness with systemic low-grade inflammatory state in a population sample of children.
Methods
Altogether 391 children aged 6–9 years were examined. Cardiorespiratory fitness (maximal power output, Wmax) was assessed by a maximal cycle ergometer test and neuromuscular fitness by hand grip strength, sit-up, standing long jump, 50-metre shuttle run, static balance, sit-and-reach, and box and block tests. Body fat percentage (BF%) and lean mass (LM) were assessed by dual-energy X-ray absorptiometry. High sensitivity C-reactive protein (hs-CRP), leptin, leptin receptor, high molecular weight adiponectin (HMW-adiponectin), interleukin-6 (IL-6), tumour necrosis factor alpha (TNF-α), and glycoprotein acetyls (GlycA) were assessed from fasting blood samples. The modified inflammatory score (IS) was calculated using the population specific z-scores and formula (zhs-CRP + zleptin + zIL-6 + zTNF-α + zGlycA) – zleptin receptor – zHMW-adiponectin. The data were analysed using linear regression analyses.
Results
Higher Wmax/kg of body mass (β=-0.416, 95% CI=-0.514 to -0.318), higher number of completed sit-ups (β=-0.147, 95% CI=-0.244 to -0.049), a longer distance jumped in the standing long jump test (β=-0.270, 95% CI=-0.371 to -0.169), and a shorter time in the 50 metre shuttle run test (β=0.123, 95% CI=0.022 to 0.223) were associated with lower IS. None of these associations remained statistically significant after adjustment for BF%
Conclusions
Higher physical fitness is associated with more favourable inflammatory biomarker profile in children. However, the associations were explained by BF%.
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Julkaisija
WileyISSN Hae Julkaisufoorumista
0905-7188Asiasanat
Julkaisu tutkimustietojärjestelmässä
https://converis.jyu.fi/converis/portal/detail/Publication/176956135
Metadata
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Lisätietoja rahoituksesta
The PANIC study has been supported financially by grants from Ministry of Education and Culture of Finland, Ministry of Social Affairs and Health of Finland, Research Committee of the Kuopio University Hospital Catchment Area (State Research Funding), Finnish Innovation Fund Sitra, Social Insurance Institution of Finland, Finnish Cultural Foundation, Foundation for Paediatric Research, Diabetes Research Foundation in Finland, Finnish Foundation for Cardiovascular Research, Juho Vainio Foundation, Paavo Nurmi Foundation, Yrjö Jahnsson Foundation, and the city of Kuopio. ...Lisenssi
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