dc.contributor.author | Kastinen, Meeri | |
dc.contributor.author | Sirniö, Päivi | |
dc.contributor.author | Elomaa, Hanna | |
dc.contributor.author | Ahtiainen, Maarit | |
dc.contributor.author | Väyrynen, Sara A. | |
dc.contributor.author | Herzig, Karl-Heinz | |
dc.contributor.author | Meriläinen, Sanna | |
dc.contributor.author | Aro, Raila | |
dc.contributor.author | Häivälä, Reetta | |
dc.contributor.author | Rautio, Tero | |
dc.contributor.author | Saarnio, Juha | |
dc.contributor.author | Wirta, Erkki-Ville | |
dc.contributor.author | Helminen, Olli | |
dc.contributor.author | Seppälä, Toni T. | |
dc.contributor.author | Kuopio, Teijo | |
dc.contributor.author | Böhm, Jan | |
dc.contributor.author | Tuomisto, Anne | |
dc.contributor.author | Mecklin, Jukka-Pekka | |
dc.contributor.author | Mäkinen, Markus J. | |
dc.contributor.author | Väyrynen, Juha P. | |
dc.date.accessioned | 2023-04-14T11:02:33Z | |
dc.date.available | 2023-04-14T11:02:33Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Kastinen, M., Sirniö, P., Elomaa, H., Ahtiainen, M., Väyrynen, S. A., Herzig, K.-H., Meriläinen, S., Aro, R., Häivälä, R., Rautio, T., Saarnio, J., Wirta, E.-V., Helminen, O., Seppälä, T. T., Kuopio, T., Böhm, J., Tuomisto, A., Mecklin, J.-P., Mäkinen, M. J., & Väyrynen, J. P. (2023). Immunological and prognostic significance of tumour necrosis in colorectal cancer. <i>British Journal of Cancer</i>, <i>128</i>(12), 2218-2226. <a href="https://doi.org/10.1038/s41416-023-02258-2" target="_blank">https://doi.org/10.1038/s41416-023-02258-2</a> | |
dc.identifier.other | CONVID_182700447 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/86353 | |
dc.description.abstract | Background
Colorectal cancer (CRC) causes the second most cancer deaths worldwide, but the disease course varies according to tumour characteristics and immunological factors. Our objective was to examine the associations of tumour necrosis with tumour characteristics, immune cell infiltrates, serum cytokine concentrations, as well as prognosis in CRC.
Methods
Three independent CRC cohorts, including 1413 patients, were analysed. Associations of the areal percentage of tumour necrosis with clinicopathologic parameters, tumour infiltrating immune cells, cytokine concentrations in systemic and mesenteric vein blood, and survival were examined.
Results
Higher tumour necrosis percentage associated with shorter colorectal cancer-specific survival independent of tumour grade, T, N or M-class, mismatch repair status, BRAF status, and other possible confounding factors. In the largest cohort (N = 1100), the HR for high tumour necrosis percentage (≥40% vs. <3%) was 3.22 (95% CI 1.68–6.17, Ptrend < 0.0001). Tumour necrosis percentage positively correlated with peripheral serum levels of CXCL8, a proinflammatory chemokine, and negatively correlated with mesenteric serum levels of CXCL10 and mast cell densities in the invasive margin of the tumour.
Conclusions
Our results support the value of tumour necrosis as a prognostic factor in colorectal cancer. CXCL8 may have a role in the systemic effects of tumour necrosis. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.relation.ispartofseries | British Journal of Cancer | |
dc.rights | CC BY 4.0 | |
dc.subject.other | cancer microenvironment | |
dc.subject.other | colorectal cancer | |
dc.subject.other | tumour biomarkers | |
dc.title | Immunological and prognostic significance of tumour necrosis in colorectal cancer | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202304142479 | |
dc.contributor.laitos | Matemaattis-luonnontieteellinen tiedekunta | fi |
dc.contributor.laitos | Bio- ja ympäristötieteiden laitos | fi |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Mathematics and Science | en |
dc.contributor.laitos | Department of Biological and Environmental Science | en |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Solu- ja molekyylibiologia | fi |
dc.contributor.oppiaine | Cell and Molecular Biology | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.format.pagerange | 2218-2226 | |
dc.relation.issn | 0007-0920 | |
dc.relation.numberinseries | 12 | |
dc.relation.volume | 128 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2023 the Authors | |
dc.rights.accesslevel | openAccess | fi |
dc.subject.yso | syöpätaudit | |
dc.subject.yso | biomarkkerit | |
dc.subject.yso | kasvaimet | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p678 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p12288 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2299 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1038/s41416-023-02258-2 | |
jyx.fundinginformation | This study was funded by Cancer Foundation Finland (59-5619 to JPV). Open Access funding provided by University of Oulu including Oulu University Hospital. | |
dc.type.okm | A1 | |