Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats
Mäkinen, E., Wikgren, J., Pekkala, S., Koch, L. G., Britton, S. L., Nokia, M. S., & Lensu, S. (2023). Genotype determining aerobic exercise capacity associates with behavioral plasticity in middle-aged rats. Behavioural Brain Research, 443, Article 114331. https://doi.org/10.1016/j.bbr.2023.114331
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Behavioural Brain ResearchAuthors
Date
2023Discipline
LiikuntalääketiedePsykologiaMonitieteinen aivotutkimuskeskusLiikuntafysiologiaHyvinvoinnin tutkimuksen yhteisöKäyttäytymisen muutos, hyvinvointi ja terveys elämänkulussaSports and Exercise MedicinePsychologyCentre for Interdisciplinary Brain ResearchExercise PhysiologySchool of WellbeingBehaviour change, health, and well-being across the lifespanCopyright
© 2023 The Authors. Published by Elsevier B.V.
Good aerobic fitness associates positively with cognitive performance and brain health and conversely, low aerobic fitness predisposes to neurodegenerative diseases. To study how genotype together with exercise, started at older age, affects brain and behavior, we utilized rats that differ in inherited aerobic fitness. Rats bred for Low Capacity for Running (LCR) are shown to display less synaptic plasticity and more inflammation in the hippocampus and perform worse than rats bred for a High Capacity for Running (HCR) in tasks requiring flexible cognition. Here we used middle-aged (∼ 16 months) HCR and LCR rats to study how genotype and sex associate with anxiety and neural information filtering, termed sensory gating. Further, we assessed how inherited aerobic capacity associates with hippocampus-dependent learning, measured with contextual fear conditioning task. In females, we also investigated the effects of voluntary wheel running (5 weeks) on these characteristics. Our results indicate that independent of sex or voluntary running, HCR rats were more anxious in open-field tasks, exhibited lower sensory gating and learned more efficiently in contextual fear conditioning task than LCR rats. Voluntary running did not markedly affect innate behavior but slightly decreased the differences between female LCR and HCR rats in fear learning. In conclusion, inherited fitness seems to determine cognitive and behavioral traits independent of sex. Although the traits proved to be rather resistant to change at adult age, learning was slightly improved following exercise in LCR females, prone to obesity and poor fitness.
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Elsevier BVISSN Search the Publication Forum
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https://converis.jyu.fi/converis/portal/detail/Publication/176940003
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Research Council of FinlandFunding program(s)
Academy Research Fellow, AoF; Academy Project, AoFAdditional information about funding
EM and SP were funded by the Academy of Finland research Fellow grant of SP (Grant ID 308042). Sanna Lensu and Miriam Nokia were funded by the Academy of Finland (Grant ID 316966 to Markku Penttonen and 321522 to Miriam Nokia). The foundation of Jenny and Antti Wihuri and the Central Finland Regional fund of the Finnish Cultural Foundation are acknowledged for their personal grants to SL. The LCR-HCR rat model system was funded by National Institutes of Health Office of Research Infrastructure Programs Grant P40OD-021331 (to L. G. Koch and S. L. Britton). The project was supported by the Academy of Finland funding to the University of Jyväskylä, profiling areas PACTS2 and BC-Well. ...License
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