Broad-spectrum antivirals from nature: studies on efficacy and molecular mechanism
Viral diseases and their outbreaks continue to challenge our society. They are not
only responsible for causing numerous infections but also disrupt the global
economy and public health system. The recent COVID-19 pandemic was one of
the most catastrophic event in human history that caused millions of fatalities
worldwide. Enteroviruses are group of viruses that cause an array of diseases
ranging from the mild, common cold to more severe infections like myocarditis
and central nervous system infections. They are also associated with chronic
infections such as type I diabetes. Currently, no antivirals have been clinically
approved against enteroviruses and only one drug has been granted a
conditional marketing authorization against coronaviruses by the European
medicines agency (EMA). It has become important that one looks beyond the
conventional routes and explore bioactive compounds from natural products to
identify novel broad-spectrum antivirals. This study concentrates on the
scre
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Publisher
Jyväskylän yliopistoISBN
978-951-39-9293-4ISSN Search the Publication Forum
2489-9003Contains publications
- Artikkeli I: Pap, N., Reshamwala, D., Korpinen, R., Kilpeläinen, P., Fidelis, M., Furtado, M. M., Sant’Ana, A. S., Wen, M., Zhang, L., Hellström, J., Marnilla, P., Mattila, P., Sarjala, T., Yang, B., dos Santos Lima, A., Azevedo, L., Marjomäki, V., & Granato, D. (2021). Toxicological and bioactivity evaluation of blackcurrant press cake, sea buckthorn leaves and bark from Scots pine and Norway spruce extracts under a green integrated approach. Food and Chemical Toxicology, 153, Article 112284. DOI: 10.1016/j.fct.2021.112284
- Artikkeli II: Granato, D., Reshamwala, D., Korpinen, R., Azevedo, L., Vieira do Carmo, M. A., Cruz, T. M., Marques, M. B., Wen, M., Zhang, L., Marjomäki, V., & Kilpeläinen, P. (2022). From the forest to the plate – Hemicelluloses, galactoglucomannan, glucuronoxylan, and phenolic-rich extracts from unconventional sources as functional food ingredients. Food chemistry, 381, Article 132284. DOI: 10.1016/j.foodchem.2022.132284
- Artikkeli III: Tienaho, J., Reshamwala, D., Karonen, M., Silvan, N., Korpela, L., Marjomäki, V., & Sarjala, T. (2021). Field-Grown and In Vitro Propagated Round-Leaved Sundew (Drosera rotundifolia L.) Show Differences in Metabolic Profiles and Biological Activities. Molecules, 26(12), Article 3581. DOI: 10.3390/molecules26123581
- Artikkeli IV: Tienaho, J., Reshamwala, D., Sarjala, T., Kilpeläinen, P., Liimatainen, J., Dou, J., Viherä-Aarnio, A., Linnakoski, R., Marjomäki, V., & Jyske, T. (2021). Salix spp. Bark Hot Water Extracts Show Antiviral, Antibacterial, and Antioxidant Activities : The Bioactive Properties of 16 Clones. Frontiers in Bioengineering and Biotechnology, 9, Article 797939. DOI: 10.3389/fbioe.2021.797939
- Artikkeli V: Reshamwala D., Shroff S., Tienaho J., Liimatainen J., Laajala M., Kilpeläinen P, Viherä-Aarnio A., Jyske T & Marjomäki V. (2022). Willow (Salix spp.) bark hot water extracts show antiviral activity for both enveloped coronaviruses and non-enveloped enteroviruses. Manuscript.
- Artikkeli VI: Reshamwala D., Linnakoski R., Shroff S., Laajala M., Civra A., Francese R., Veteli P., Cortina-Escribano M., Liimatainen J., Tienaho J., Sarjala T., Lembo D., Vanhanene H. & Marjomäki V. (2022). Selected strains of Ganoderma sp. from Finnish forests have excellent broadly acting antiviral properties. Manuscript.
- Artikkeli VII: Reshamwala, D., Shroff, S., Sheik, A. O., Laquintana, V., Denora, N., Zacheo, A., Lampinen, V., Hytonen, V. P., Tastan, B. Ö., Krol, S., & Marjomäki, V. (2021). Polyphenols Epigallocatechin Gallate and Resveratrol, and Polyphenol-Functionalized Nanoparticles Prevent Enterovirus Infection through Clustering and Stabilization of the Viruses. Pharmaceutics, 13(8), Article 1182. DOI: 10.3390/pharmaceutics13081182
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