Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project

Pietiläinen, Kirsi H.; Mäkinen, Elina; Lensu, Sanna; Laukkanen, Jari A.; Hakkarainen, Antti; Kuula, Juho; Juvonen, Risto; O’Connell, Thomas; Keski-Rahkonen, Pekka; Lehtonen, Marko; Pekkala, Satu; Hintikka, Jukka

doi:10.17011/jyx/dataset/85068

Rasvamaksan biomarkkeriaineisto hankkeesta Personoitu ravitsemusinterventio rasvamaksan hoitamiseksi

Anastasiia Driuchina; Jukka Hintikka; Marko Lehtonen; Pekka Keski-Rahkonen; Thomas O’Connell; Risto Juvonen; Juho Kuula; Antti Hakkarainen; Jari A. Laukkanen; Elina Mäkinen; Sanna Lensu et al. (2023). Liver fat biomarkers study from the 'Personalized diet intervention to treat fatty liver' project. 10.17011/jyx/dataset/85068

Tekijät

Pietiläinen, Kirsi H. |

Mäkinen, Elina |

Lensu, Sanna |

Laukkanen, Jari A. |

Hakkarainen, Antti |

Kuula, Juho |

Juvonen, Risto |

O’Connell, Thomas |

Keski-Rahkonen, Pekka |

Lehtonen, Marko |

Pekkala, Satu |

Hintikka, Jukka

Muut tutkimuksen toteuttamiseen osallistuneet

Helsingin yliopisto; University of Jyväskylä; University of Eastern Finland; Hospital District of Helsinki and Uusimaa; University of Helsinki; Jyväskylän yliopisto; Itä-Suomen yliopisto (ISY); Helsingin ja Uudenmaan sairaanhoitopiiri

Päivämäärä

2023

Pääsyrajoitukset

Restricted use due to personal information protection. You can still contact author to ask for a copy of the material.

Tekijänoikeudet

Pekkala, Satu and University of Jyväskylä

The study aimed at finding gut microbiota signatures and metabolite markers in plasma and feces related to high liver fat content in humans. Based on imaging, we divided study participants into low (<5%, LF, n=25) and high (>5%, HF, n=39) liver fat groups. Fecal (LF n=14, HF n=25) and plasma (LF n=11, HF n=7) metabolomes of subsets of participants were studied using liquid chromatography/high resolution mass spectrometry. The gut microbiota were analyzed using 16S rRNA gene sequencing. Additionally, blood clinical variables, body composition and diet were studied. The list of metadata variables can be found below. They are categorized by the type of sample and/or analysis. BLOOD CLINICAL VARIABLES & UNITS alanine aminotransferase, ALT (U/L) aspartate aminotransferase, AST (U/L) gamma-glutamyltransferase, GGT(U/L) total cholesterol (mmol/L) high-density lipoprotein, HDL (mmol/L) low-density lipoprotein, LDL (mmol/L) triglycrides (mmol/L) glucose (mmol/L) insulin (iU/L ... showmore

Rahoittaja(t)

Academy of Finland; Suomen Akatemia

Rahoitusohjelmat(t)

Academy Research Fellow, AoF; Akatemiatutkija, SA

Lisenssi