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dc.contributor.authorBelavy, Daniel L.
dc.contributor.authorMiller, Clint T.
dc.contributor.authorOwen, Patrick J.
dc.contributor.authorRantalainen, Timo
dc.contributor.authorConnell, David
dc.contributor.authorHahne, Andrew J.
dc.contributor.authorFord, Jon J.
dc.contributor.authorTrudel, Guy
dc.date.accessioned2022-11-11T10:41:44Z
dc.date.available2022-11-11T10:41:44Z
dc.date.issued2022
dc.identifier.citationBelavy, D. L., Miller, C. T., Owen, P. J., Rantalainen, T., Connell, D., Hahne, A. J., Ford, J. J., & Trudel, G. (2022). Exercise may impact on lumbar vertebrae marrow adipose tissue : Randomised controlled trial. <i>Bone</i>, <i>157</i>, Article 116338. <a href="https://doi.org/10.1016/j.bone.2022.116338" target="_blank">https://doi.org/10.1016/j.bone.2022.116338</a>
dc.identifier.otherCONVID_104304015
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/83861
dc.description.abstractBackground Animal and human cross-sectional data suggest that bone marrow adipose tissue (MAT) may respond to mechanical loads and exercise. We conducted the first randomised controlled trial of exercise on MAT modulations in humans. Methods Forty patients with chronic non-specific low back pain (NSCLBP) were enrolled in a six-month single-blinded randomised controlled trial (ACTRN12615001270505). Twenty patients loaded their spines via progressive upright aerobic and resistance exercises targeting major muscle groups (Exercise). Twenty patients performed non-weightbearing motor control training and manual therapy (Control). Testing occurred at baseline, 3-months (3mo) and 6-months (6mo). Lumbar vertebral fat fraction (VFF) was measured using magnetic resonance imaging axial mDixon sequences. Results When compared to baseline (percent change), lumbar vertebral fat fraction (VFF; measured using magnetic resonance imaging axial mDixon sequences) was lower in Exercise at 3mo at L2 (−3.7[6.8]%, p = 0.033) and L4 (−2.6[4.1]%, p = 0.015), but not in Control. There were no between-group effects. The effects of Exercise on VFF were sex-specific, with VFF lower in men at L2, L3, L4 at 3mo and at L1, L2, L3 and L4 at 6mo (p all ≤ 0.05), but not in women. Leg and trunk lean mass were increased at 3mo in Exercise. Changes in VFF correlated significantly with changes in total fat (ρ = 0.40) and lean (ρ = −0.41) masses, but not with lumbar BMD (ρ = −0.10) or visceral adipose tissue volume (ρ = 0.23). Conclusions This trial provided first prospective evidence in humans that a moderate exercise intervention may modulate lumbar VFF as a surrogate measure of MAT at 3mo, yet not 6mo. The effect of exercise on MAT may be more prominent in males than females.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesBone
dc.rightsCC BY-NC-ND 4.0
dc.subject.otherexercise
dc.subject.otherrehabilitation
dc.subject.otherback pain
dc.subject.otherspine
dc.subject.othermagnetic resonance imaging
dc.subject.othermarrow adipose tissue
dc.titleExercise may impact on lumbar vertebrae marrow adipose tissue : Randomised controlled trial
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202211115159
dc.contributor.laitosLiikuntatieteellinen tiedekuntafi
dc.contributor.laitosFaculty of Sport and Health Sciencesen
dc.contributor.oppiaineBiomekaniikkafi
dc.contributor.oppiaineGerontologia ja kansanterveysfi
dc.contributor.oppiaineGerontologian tutkimuskeskusfi
dc.contributor.oppiaineHyvinvoinnin tutkimuksen yhteisöfi
dc.contributor.oppiaineBiomechanicsen
dc.contributor.oppiaineGerontology and Public Healthen
dc.contributor.oppiaineGerontology Research Centeren
dc.contributor.oppiaineSchool of Wellbeingen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.relation.issn8756-3282
dc.relation.volume157
dc.type.versionacceptedVersion
dc.rights.copyright© 2022 Elsevier Inc. All rights reserved.
dc.rights.accesslevelopenAccessfi
dc.subject.ysoselkäranka
dc.subject.ysorasvakudokset
dc.subject.ysoliikuntahoito
dc.subject.ysofysiologiset vaikutukset
dc.subject.ysokrooninen kipu
dc.subject.ysoluuydin
dc.subject.ysoselkä
dc.subject.ysokuntoliikunta
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p110
jyx.subject.urihttp://www.yso.fi/onto/yso/p24382
jyx.subject.urihttp://www.yso.fi/onto/yso/p7811
jyx.subject.urihttp://www.yso.fi/onto/yso/p11511
jyx.subject.urihttp://www.yso.fi/onto/yso/p16952
jyx.subject.urihttp://www.yso.fi/onto/yso/p11618
jyx.subject.urihttp://www.yso.fi/onto/yso/p108
jyx.subject.urihttp://www.yso.fi/onto/yso/p3708
dc.rights.urlhttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.relation.doi10.1016/j.bone.2022.116338
jyx.fundinginformationThis study was supported by internal institutional funding (Deakin University School of Exercise and Nutrition Sciences, reference number Belavy 2014–2017).
dc.type.okmA1


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