Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
Kalenga, T. M., Mollel, J. T., Said, J., Orthaber, A., Ward, J. S., Atilaw, Y., Umereweneza, D., Ndoile, M. M., Munissi, J. J. E., Rissanen, K., Trybala, E., Bergström, T., Nyandoro, S. S., & Erdelyi, M. (2022). Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis. Journal of Natural Products, 85(9), 2135-2141. https://doi.org/10.1021/acs.jnatprod.2c00147
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Journal of Natural ProductsDate
2022Copyright
© 2022 The Authors. Published by American Chemical Society and American Society of Pharmacognosy
The leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.
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American Chemical Society (ACS)ISSN Search the Publication Forum
0163-3864Publication in research information system
https://converis.jyu.fi/converis/portal/detail/Publication/155906454
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The Swedish Research Council (Project No. 2019-03715), the University of Dar es Salaam Competitive Research and Publication Grant (CoNAS-CH 18035), and the Ministry of Education, Science and Technology, Republic of Tanzania, are acknowledged for funding. This study made use of the NMR Uppsala infrastructure funded by the Department of Chemistry − BMC and the Disciplinary Domain of Medicine and Ph ...
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