Näytä suppeat kuvailutiedot

dc.contributor.authorKalenga, Thobias M.
dc.contributor.authorMollel, Jackson T.
dc.contributor.authorSaid, Joanna
dc.contributor.authorOrthaber, Andreas
dc.contributor.authorWard, Jas S.
dc.contributor.authorAtilaw, Yoseph
dc.contributor.authorUmereweneza, Daniel
dc.contributor.authorNdoile, Monica M.
dc.contributor.authorMunissi, Joan J. E.
dc.contributor.authorRissanen, Kari
dc.contributor.authorTrybala, Edward
dc.contributor.authorBergström, Tomas
dc.contributor.authorNyandoro, Stephen S.
dc.contributor.authorErdelyi, Mate
dc.date.accessioned2022-09-14T06:29:27Z
dc.date.available2022-09-14T06:29:27Z
dc.date.issued2022
dc.identifier.citationKalenga, T. M., Mollel, J. T., Said, J., Orthaber, A., Ward, J. S., Atilaw, Y., Umereweneza, D., Ndoile, M. M., Munissi, J. J. E., Rissanen, K., Trybala, E., Bergström, T., Nyandoro, S. S., & Erdelyi, M. (2022). Modified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis. <i>Journal of Natural Products</i>, <i>85</i>(9), 2135-2141. <a href="https://doi.org/10.1021/acs.jnatprod.2c00147" target="_blank">https://doi.org/10.1021/acs.jnatprod.2c00147</a>
dc.identifier.otherCONVID_155906454
dc.identifier.urihttps://jyx.jyu.fi/handle/123456789/83240
dc.description.abstractThe leaf extract of Suregada zanzibariensis gave two new modified ent-abietane diterpenoids, zanzibariolides A (1) and B (2), and two known triterpenoids, simiarenol (3) and β-amyrin (4). The structures of the isolated compounds were elucidated based on NMR and MS data analysis. Single-crystal X-ray diffraction was used to establish the absolute configurations of compounds 1 and 2. The crude leaf extract inhibited the infectivity of herpes simplex virus 2 (HSV-2, IC50 11.5 μg/mL) and showed toxicity on African green monkey kidney (GMK AH1) cells at CC50 52 μg/mL. The isolated compounds 1–3 showed no anti-HSV-2 activity and exhibited insignificant toxicity against GMK AH1 cells at ≥100 μM.en
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.relation.ispartofseriesJournal of Natural Products
dc.rightsCC BY 4.0
dc.titleModified ent-Abietane Diterpenoids from the Leaves of Suregada zanzibariensis
dc.typearticle
dc.identifier.urnURN:NBN:fi:jyu-202209144586
dc.contributor.laitosKemian laitosfi
dc.contributor.laitosDepartment of Chemistryen
dc.contributor.oppiaineOrgaaninen kemiafi
dc.contributor.oppiaineOrganic Chemistryen
dc.type.urihttp://purl.org/eprint/type/JournalArticle
dc.type.coarhttp://purl.org/coar/resource_type/c_2df8fbb1
dc.description.reviewstatuspeerReviewed
dc.format.pagerange2135-2141
dc.relation.issn0163-3864
dc.relation.numberinseries9
dc.relation.volume85
dc.type.versionpublishedVersion
dc.rights.copyright© 2022 The Authors. Published by American Chemical Society and American Society of Pharmacognosy
dc.rights.accesslevelopenAccessfi
dc.subject.ysotyräkkikasvit
dc.subject.ysoluonnonaineet
dc.subject.ysoinhibiittorit
dc.subject.ysobioaktiiviset yhdisteet
dc.subject.ysoterpeenit
dc.subject.ysomyrkyllisyys
dc.format.contentfulltext
jyx.subject.urihttp://www.yso.fi/onto/yso/p16634
jyx.subject.urihttp://www.yso.fi/onto/yso/p6956
jyx.subject.urihttp://www.yso.fi/onto/yso/p24325
jyx.subject.urihttp://www.yso.fi/onto/yso/p28433
jyx.subject.urihttp://www.yso.fi/onto/yso/p12115
jyx.subject.urihttp://www.yso.fi/onto/yso/p12637
dc.rights.urlhttps://creativecommons.org/licenses/by/4.0/
dc.relation.doi10.1021/acs.jnatprod.2c00147
jyx.fundinginformationThe Swedish Research Council (Project No. 2019-03715), the University of Dar es Salaam Competitive Research and Publication Grant (CoNAS-CH 18035), and the Ministry of Education, Science and Technology, Republic of Tanzania, are acknowledged for funding. This study made use of the NMR Uppsala infrastructure funded by the Department of Chemistry − BMC and the Disciplinary Domain of Medicine and Pharmacy. Mr. F. M. Mbago of the Botany Department at the University of Dar es Salaam is acknowledged for locating and identifying the investigated plant species.
dc.type.okmA1


Aineistoon kuuluvat tiedostot

Thumbnail

Aineisto kuuluu seuraaviin kokoelmiin

Näytä suppeat kuvailutiedot

CC BY 4.0
Ellei muuten mainita, aineiston lisenssi on CC BY 4.0