dc.contributor.author | Hinrichs, Timo | |
dc.contributor.author | Portegijs, Erja | |
dc.contributor.author | Rantanen, Taina | |
dc.contributor.author | Infanger, Denis | |
dc.contributor.author | Schmidt-Trucksäss, Arno | |
dc.contributor.author | Karavirta, Laura | |
dc.date.accessioned | 2022-08-23T10:11:28Z | |
dc.date.available | 2022-08-23T10:11:28Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Hinrichs, T., Portegijs, E., Rantanen, T., Infanger, D., Schmidt-Trucksäss, A., & Karavirta, L. (2022). Association between arterial stiffness and walking capacity in older adults. <i>Experimental Gerontology</i>, <i>167</i>, Article 111925. <a href="https://doi.org/10.1016/j.exger.2022.111925" target="_blank">https://doi.org/10.1016/j.exger.2022.111925</a> | |
dc.identifier.other | CONVID_151699052 | |
dc.identifier.uri | https://jyx.jyu.fi/handle/123456789/82762 | |
dc.description.abstract | Background and aim
Arterial stiffening – a process that is largely due to intimal thickening, collagen disposition or elastin fragmentation – significantly contributes to cardiovascular events and mortality. There is also some evidence that it may negatively affect physical function. This study aimed to evaluate whether arterial stiffness was associated with measures of walking capacity in a large, population-based sample of highly aged older adults.
Methods
A population-based sample of 910 community-dwelling adults (aged 75, 80, or 85 years) were investigated in a cross-sectional observational study. Pulse wave velocity (PWV), a surrogate marker of arterial stiffness, was estimated based on the oscillometric recording of pulse waves at the brachial artery site. Walking capacity was assessed by 10-meter habitual walking speed, 10-meter maximum walking speed, and six-minute walk distance. We used multiple linear regression models to examine possible associations between PWV and parameters of walking capacity, and we adjusted the models for sex, age, socioeconomic status, anthropometry, physician-diagnosed diseases, prescription medication, smoking history, physical activity, and mean arterial pressure. Continuous variables were modelled using restricted cubic splines to account for potential nonlinear associations.
Results
Mean (standard deviation) 10-meter habitual walking speed, 10-meter maximum walking speed, and six-minute walk distance were 1.3 (0.2) m/s, 1.7 (0.4) m/s, and 413 (85) m, respectively. The fully adjusted regression models revealed no evidence for associations between PWV and parameters of walking capacity (all p-values >0.05).
Conclusion
Our results did not confirm previous findings suggesting a potential negative association between arterial stiffness and walking capacity in old age. Longitudinal studies, potentially taking additional confounders into account, are needed to disentangle the complex relationship between the two factors. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | eng | |
dc.publisher | Elsevier | |
dc.relation.ispartofseries | Experimental Gerontology | |
dc.rights | CC BY 4.0 | |
dc.subject.other | Octogenarian | |
dc.subject.other | Vascular stiffness | |
dc.subject.other | Pulse wave analysis | |
dc.subject.other | Mobility limitation | |
dc.subject.other | Population-based | |
dc.title | Association between arterial stiffness and walking capacity in older adults | |
dc.type | article | |
dc.identifier.urn | URN:NBN:fi:jyu-202208234299 | |
dc.contributor.laitos | Liikuntatieteellinen tiedekunta | fi |
dc.contributor.laitos | Faculty of Sport and Health Sciences | en |
dc.contributor.oppiaine | Gerontologia ja kansanterveys | fi |
dc.contributor.oppiaine | Gerontologian tutkimuskeskus | fi |
dc.contributor.oppiaine | Hyvinvoinnin tutkimuksen yhteisö | fi |
dc.contributor.oppiaine | Gerontology and Public Health | en |
dc.contributor.oppiaine | Gerontology Research Center | en |
dc.contributor.oppiaine | School of Wellbeing | en |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | |
dc.type.coar | http://purl.org/coar/resource_type/c_2df8fbb1 | |
dc.description.reviewstatus | peerReviewed | |
dc.relation.issn | 0531-5565 | |
dc.relation.volume | 167 | |
dc.type.version | publishedVersion | |
dc.rights.copyright | © 2022 The Authors. Published by Elsevier Inc. | |
dc.rights.accesslevel | openAccess | fi |
dc.relation.grantnumber | 310526 | |
dc.relation.grantnumber | 339391 | |
dc.relation.grantnumber | 346462 | |
dc.relation.grantnumber | 693045 | |
dc.relation.grantnumber | 693045 | |
dc.relation.projectid | info:eu-repo/grantAgreement/EC/H2020/693045/EU//AGNES | |
dc.subject.yso | ikääntyminen | |
dc.subject.yso | väestötutkimus | |
dc.subject.yso | liikuntakyky | |
dc.subject.yso | fyysinen toimintakyky | |
dc.subject.yso | ikääntyneet | |
dc.subject.yso | sydän- ja verisuonitaudit | |
dc.subject.yso | kävely | |
dc.format.content | fulltext | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p5056 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p11417 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p22622 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p27172 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p2433 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p9886 | |
jyx.subject.uri | http://www.yso.fi/onto/yso/p3706 | |
dc.rights.url | https://creativecommons.org/licenses/by/4.0/ | |
dc.relation.doi | 10.1016/j.exger.2022.111925 | |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | Research Council of Finland | en |
dc.relation.funder | European Commission | en |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Suomen Akatemia | fi |
dc.relation.funder | Euroopan komissio | fi |
jyx.fundingprogram | Academy Project, AoF | en |
jyx.fundingprogram | Academy Research Fellow, AoF | en |
jyx.fundingprogram | Research costs of Academy Research Fellow, AoF | en |
jyx.fundingprogram | ERC European Research Council, H2020 | en |
jyx.fundingprogram | Akatemiahanke, SA | fi |
jyx.fundingprogram | Akatemiatutkija, SA | fi |
jyx.fundingprogram | Akatemiatutkijan tutkimuskulut, SA | fi |
jyx.fundingprogram | ERC European Research Council, H2020 | fi |
jyx.fundinginformation | In the years 2016 to 2021, the AGNES project has been financially supported by grants of the European Research Council (grant number 693045 to TR and grant numbers 339391 and 346462 to LK) and the Academy of Finland (grant number 310526 to TR). A nested project on arterial stiffness and physical function has received additional support by Sport & Exercise Medicine Switzerland (SEMS Research Prize 2021 to TH). | |
dc.type.okm | A1 | |